Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Olga Boudker"'
Autor:
Biao Qiu, Olga Boudker
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Excitatory amino acid transporters (EAATs) uptake glutamate into glial cells and neurons. EAATs achieve million-fold transmitter gradients by symporting it with three sodium ions and a proton, and countertransporting a potassium ion via an e
Externí odkaz:
https://doaj.org/article/a2d1313c763247bbbaec6c9acf84c18d
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Excitatory amino acid transporters (EAATs) are crucial for the removal of excitatory amino acids from the synaptic cleft. Here authors combined high-speed atomic force microscopy line-scanning with automated state assignment for the determination of
Externí odkaz:
https://doaj.org/article/c95aa1629c334ed0810a6e777c977f72
Autor:
Didar Ciftci, Gerard Huysmans, Xiaoyu Wang, Changhao He, Daniel Terry, Zhou Zhou, Gabriel Fitzgerald, Scott Blanchard, Olga Boudker
Publikováno v:
Bio-Protocol, Vol 11, Iss 7 (2021)
Secondary active transporters reside in cell membranes transporting polar solutes like amino acids against steep concentration gradients, using electrochemical gradients of ions as energy sources. Commonly, ensemble-based measurements of radiolabeled
Externí odkaz:
https://doaj.org/article/0aae5647b3b64bd7b3f2b91125760732
Autor:
Xiaoyu Wang, Olga Boudker
Publikováno v:
eLife, Vol 9 (2020)
Glutamate transporters are essential players in glutamatergic neurotransmission in the brain, where they maintain extracellular glutamate below cytotoxic levels and allow for rounds of transmission. The structural bases of their function are well est
Externí odkaz:
https://doaj.org/article/d0c011c8c92d463994fc233953b3e5c7
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Cancer cells are reliant on nutrients such as glutamine, which enter the cell via the alanine/serine/cysteine transporter 2 (ASCT2). Here, authors use crystallography to show which amino-acid residues in the substrate-binding site are responsible for
Externí odkaz:
https://doaj.org/article/ab0f2812dab54201a550d895712c496d
Autor:
SeCheol Oh, Olga Boudker
Publikováno v:
eLife, Vol 7 (2018)
Many secondary active membrane transporters pump substrates against concentration gradients by coupling their uptake to symport of sodium ions. Symport requires the substrate and ions to be always transported together. Cooperative binding of the solu
Externí odkaz:
https://doaj.org/article/97bbdf91f7f04c0dac2d64b02643c6fb
Autor:
Erika A Riederer, Paul J Focke, Elka R Georgieva, Nurunisa Akyuz, Kimberly Matulef, Peter P Borbat, Jack H Freed, Scott C Blanchard, Olga Boudker, Francis I Valiyaveetil
Publikováno v:
eLife, Vol 7 (2018)
Membrane proteins such as ion channels and transporters are frequently homomeric. The homomeric nature raises important questions regarding coupling between subunits and complicates the application of techniques such as FRET or DEER spectroscopy. The
Externí odkaz:
https://doaj.org/article/39e3a06096de4aa7b5b9638d479f75a6
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0136779 (2015)
Equilibrative nucleoside transporters (ENTs) are integral membrane proteins, which reside in plasma membranes of all eukaryotic cells and mediate thermodynamically downhill transport of nucleosides. This process is essential for nucleoside recycling,
Externí odkaz:
https://doaj.org/article/f6fdaeb7f17447c8ab74059615da537c
Publikováno v:
eLife, Vol 3 (2014)
Membrane transporters that clear the neurotransmitter glutamate from synapses are driven by symport of sodium ions and counter-transport of a potassium ion. Previous crystal structures of a homologous archaeal sodium and aspartate symporter showed th
Externí odkaz:
https://doaj.org/article/98e090346a794076ac026276b600e314
Publikováno v:
Journal of the American Chemical Society.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c26d108ad7d4c488ddf53b9549c7c353
https://doi.org/10.1021/jacs.3c01003
https://doi.org/10.1021/jacs.3c01003