Zobrazeno 1 - 10
of 169
pro vyhledávání: '"Olga Bakulina"'
Publikováno v:
Molecules, Vol 28, Iss 10, p 4209 (2023)
The use of spirocycles in drug discovery and medicinal chemistry has been booming in the last two decades. This has clearly translated into the landscape of approved drugs. Among two dozen clinically used medicines containing a spirocycle, 50% have b
Externí odkaz:
https://doaj.org/article/f263e5842ecc4b8ea16388e0cf560eec
Autor:
Alexander Kazantsev, Ivan A. Rodionov, Olga Bakulina, Grigory Kantin, Dmitry Dar’in, Mikhail Krasavin
Publikováno v:
Catalysts, Vol 13, Iss 2, p 428 (2023)
(E)-3-Arylidene-4-diazopyrrolidine-2,5-diones previously shown to yield two products in reactions with tetrahydrofuran mediated by rhodium carbenes—tetrahydrofur-2-yl-substituted product of C-H insertion and spirocyclic product of formal C-O insert
Externí odkaz:
https://doaj.org/article/491263cb75364397a4a55707cde04713
Publikováno v:
Molecules, Vol 27, Iss 23, p 8462 (2022)
Novel aryl-substituted homophthalic acids were cyclodehydrated to the respective homophthalic anhydrides for use in the Castagnoli–Cushman reaction. With a range of imines, this reaction proceeded smoothly and delivered hitherto undescribed 4-aryl-
Externí odkaz:
https://doaj.org/article/2ff071a96edf41a6ad1cc8dd949195e1
Publikováno v:
Molecules, Vol 27, Iss 23, p 8130 (2022)
Realization of the one-pot Staudinger/aza-Wittig/Castagnoli–Cushman reaction sequence for a series of azido aldehydes and homophthalic anhydrides is described. The reaction proceeded at room temperature and delivered novel polyheterocycles related
Externí odkaz:
https://doaj.org/article/3294d184f2454f0489af9fa95a593735
Publikováno v:
Molecules, Vol 27, Iss 21, p 7211 (2022)
Based on the previously reported involvement of homophthalic acid monoesters in the Castagnoli–Cushman reaction-type cyclocondensation with imines, we tested a number of other o-methyl benzoic acids bearing various electron-withdrawing groups in th
Externí odkaz:
https://doaj.org/article/cfe96efa07c2485994dd2880152018b6
Autor:
Olga Bakulina, Anton Bannykh, Mirna Jovanović, Ilona Domračeva, Ana Podolski-Renić, Raivis Žalubovskis, Milica Pešić, Dmitry Dar’in, Mikhail Krasavin
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 665-671 (2019)
Human thioredoxin reductase 1 (TrxR1) is a selenocysteine-containing enzyme which plays a crucial role in regulating numerous redox signalling pathways within the cell. While its functioning is important in all cells, levels of TrxR1 expression are h
Externí odkaz:
https://doaj.org/article/56ccb2a5330943a7acddac380ac74b62
Autor:
Alexei Lukin, Mikhail Chudinov, Tatiana Vedekhina, Elizaveta Rogacheva, Lyudmila Kraeva, Olga Bakulina, Mikhail Krasavin
Publikováno v:
Molecules, Vol 27, Iss 15, p 4864 (2022)
The previously reported as well as newly synthesized derivatives of the 1-oxa-9-azaspiro[5.5]undecane were employed in the synthesis of thirty-six derivatives of ciprofloxacin using commercially available 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dih
Externí odkaz:
https://doaj.org/article/7104e93f92364046ae19f85c2d4ccfe3
Publikováno v:
Molecules, Vol 27, Iss 12, p 3910 (2022)
Screening of a library of novel N-hydroxylactams amenable by the Castagnoli-Cushman reaction identified four lead compounds that facilitated 55Fe transport into P. aeruginosa cells (one of these synthetic siderophores was found to be as efficient at
Externí odkaz:
https://doaj.org/article/a748fd7cb5a14611a4cba2e2544c6037
Publikováno v:
Molecules, Vol 27, Iss 8, p 2469 (2022)
A N-(2-methoxy-2-oxoethyl)-N-(phenylsulfonyl)glycine monomethyl ester of the respective dicarboxylic acid was involved in a reaction with imines promoted by acetic anhydride at an elevated temperature. Instead of the initially expected δ-lactam prod
Externí odkaz:
https://doaj.org/article/20a40cc9112843d38a43fe0d534176f7
Publikováno v:
Molecules, Vol 27, Iss 6, p 2030 (2022)
The reactivity of cyclic α-diazo monocarbonyl compounds differs from that of their acyclic counterparts. In this review, we summarize the current literature available on the synthesis and synthetic applications of three major classes of cyclic α-di
Externí odkaz:
https://doaj.org/article/a8a740dc5061453c9851236bf657008a