Arf GTPase activates the WAVE regulatory complex through a distinct binding site

Autor: Sheng Yang, Yubo Tang, Yijun Liu, Abbigale J. Brown, Matthias Schaks, Bojian Ding, Daniel A. Kramer, Magdalena Mietkowska, Li Ding, Olga Alekhina, Daniel D. Billadeau, Saikat Chowdhury, Junmei Wang, Klemens Rottner, Baoyu Chen

Publikováno v: Science Advances. 8

Cross-talk between Rho- and Arf-family guanosine triphosphatases (GTPases) plays an important role in linking the actin cytoskeleton to membrane protrusions, organelle morphology, and vesicle trafficking. The central actin regulator, WAVE regulatory

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dda189493f31f38c8abcc42158b44be
https://doi.org/10.1126/sciadv.add1412

Correction: Glycogen Synthase Kinase-3 Inhibition Sensitizes Pancreatic Cancer Cells to Chemotherapy by Abrogating the TopBP1/ATR-mediated DNA Damage Response

Autor: Li, Ding, Vijay S, Madamsetty, Spencer, Kiers, Olga, Alekhina, Andrey, Ugolkov, John, Dube, Yu, Zhang, Jin-San, Zhang, Enfeng, Wang, Shamit K, Dutta, Daniel M, Schmitt, Francis J, Giles, Alan P, Kozikowski, Andrew P, Mazar, Debabrata, Mukhopadhyay, Daniel D, Billadeau

Publikováno v: Clin Cancer Res

PURPOSE: Pancreatic ductal adenocarcinoma (PDAC) is a predominantly fatal common malignancy with inadequate treatment options. Glycogen synthase kinase 3β (GSK-3β) is an emerging target in human malignancies including PDAC. EXPERIMENTAL DESIGN: Pan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::68d26f7e6ac8d504d8aa911f669535ca
https://pubmed.ncbi.nlm.nih.gov/31533931

Nebulin and Lmod2 are critical for specifying thin-filament length in skeletal muscle

Autor: Balázs Kiss, Coen A.C. Ottenheijm, John E. Smith, Jochen Gohlke, Justin Kolb, Carol C. Gregorio, Olga Alekhina, Henk Granzier, Joshua Strom, Paola Tonino, Zaynab Hourani

Publikováno v: Science Advances
Science Advances, 6(46):eabc1992. American Association for the Advancement of Science
Kiss, B, Gohlke, J, Tonino, P, Hourani, Z, Kolb, J, Strom, J, Alekhina, O, Smith, J E, Ottenheijm, C A C, Gregorio, C & Granzier, H 2020, ' Nebulin and Lmod2 are critical for specifying thin-filament length in skeletal muscle ', Science Advances, vol. 6, no. 46, eabc1992 . https://doi.org/10.1126/sciadv.abc1992

Nebulin rules thin-filament length in fast skeletal muscle but collaborates with leiomodin-2 in muscles optimized for efficiency.
Regulating the thin-filament length in muscle is crucial for controlling the number of myosin motors that generate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85c9409b57b60e5d1ace3893f81e760e
https://doi.org/10.1126/sciadv.abc1992

Trans -endocytosis elicited by nectins transfers cytoplasmic cargo, including infectious material, between cells

Autor: Chanakha K. Navaratnarajah, Lawrence Shapiro, Alex R. Generous, Ryan C. Donohue, Barry Honig, Olga Alekhina, Sergey M. Troyanovsky, Alina P. Sergeeva, Mathieu Mateo, Roberto Cattaneo, Irina Kochetkova, Regina B. Troyanovsky, Theresa Thornburg, O.J. Harrison, Matthew P. Taylor, Daniel D. Billadeau, Indrajyoti Indra, Christian K. Pfaller

Publikováno v: Journal of Cell Science
Journal of Cell Science, Company of Biologists, 2019, 132 (16), pp.jcs235507. ⟨10.1242/jcs.235507⟩
J Cell Sci

International audience; Here, we show that cells expressing the adherens junction protein nectin-1 capture nectin-4-containing membranes from the surface of adjacent cells in a trans-endocytosis process. We find that internalized nectin-1-nectin-4 co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24aa7d5af40b18ec7cb3920c6aae1418
https://hal.archives-ouvertes.fr/hal-02864143

Personnel Security in the conditions of digitalization of the Economy

Autor: Andrey Bystrov, Olga Alekhina, Galina Ignatyeva, Irina Manakhova

Publikováno v: Proceedings of the Volgograd State University International Scientific Conference "Competitive, Sustainable and Safe Development of the Regional Economy" (CSSDRE 2019).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3b2ab54e584632e16978a1595720b706
https://doi.org/10.2991/cssdre-19.2019.76