Investigating the Kinetic Mechanism of Inhibition of Elongation Factor 2 Kinase by NH125: Evidence of a Common in Vitro Artifact

Autor: Kevin N. Dalby, Bulent Ozpolat, Kivanc Gorgulu, Olga Abramczyk, Kyle D. Marshall, Clint D.J. Tavares, Tamer S. Kaoud, Ashwini K. Devkota, Mangalika Warthaka

Publikováno v: Biochemistry. 51:2100-2112

Evidence that elongation factor 2 kinase (eEF-2K) has potential as a target for anticancer therapy and possibly for the treatment of depression is emerging. Here the steady-state kinetic mechanism of eEF-2K is presented using a peptide substrate and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0db5c61e632d66d40a20ca36a2f33c4b
https://doi.org/10.1021/bi201787p

EFSA Stakeholders' benefits analysis from the future implementation of an electronic submission tool

Autor: Eszter Kantor, Olga Abramczyk, David Mosler, Diletta Zonta

Publikováno v: EFSA Supporting Publications. 12

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d3e599c417c8d328da13258782a16808
https://doi.org/10.2903/sp.efsa.2015.en-814

The protein kinase 60S is a free catalytic CK2α′ subunit and forms an inactive complex with superoxide dismutase SOD1

Autor: Ulf Hellman, Rafal Zielinski, Marek Pilecki, Ryszard Szyszka, Olga Abramczyk, Piotr Zień

Publikováno v: Biochemical and Biophysical Research Communications. 307:31-40

The 60S ribosomes from Saccharomyces cerevisiae contain a set of acidic P-proteins playing an important role in the ribosome function. Reversible phosphorylation of those proteins is a mechanism regulating translational activity of ribosomes. The key

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36452f31417426aed227c3c366ab641c
https://doi.org/10.1016/s0006-291x(03)01126-4

Impact of oncogenic driver mutations on feedback between the PI3K and MEK pathways in cancer cells

Autor: Senji Shirasawa, Yu-Han Huang, Mohamed El-Tanani, Kwok Wah Chan, Grant W. Montgomery, Ka-Kui Chan, Srivastava Gopesh, Hiu-Fung Yuen, Dean A. Fennell, Takehiko Sasazuki, Olga Abramczyk, James Murray, Pasi A. Jänne

Publikováno v: Yuen, H-F, Abramczyk, O, Montgomery, G, Chan, K-K, Huang, Y-H, Sasazuki, T, Shirasawa, S, Gopesh, S, Chan, K-W, Fennell, D, Janne, P, El-Tanani, M & Murray, J T 2012, ' Impact of oncogenic driver mutations on feedback between the PI3K and MEK pathways in cancer cells ', Bioscience Reports, vol. 32, no. 4, pp. 413-422 . https://doi.org/10.1042/BSR20120050
Bioscience Reports
Bioscience Reports, Vol 32, Iss 4 (2012)

Inhibition of the PI3K (phosphoinositide 3-kinase)/Akt/mTORC1 (mammalian target of rapamycin complex 1) and Ras/MEK [MAPK (mitogen-activated protein kinase)/ERK (extracellular-signal-regulated kinase) kinase]/ERK pathways for cancer therapy has been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c384c493de84bdf97b2a450206e43042
https://cronfa.swan.ac.uk/Record/cronfa56415

Solution NMR Insights into Docking Interactions Involving Inactive ERK2†

Autor: Ashwini K. Devkota, Mangalika Warthaka, Tamer S. Kaoud, Kevin N. Dalby, Olga Abramczyk, Ranajeet Ghose, Pengyu Ren, Sunbae Lee, Andrea Piserchio

The mitogen activated protein (MAP) kinase ERK2 contains recruitment sites that engage canonical and non-canonical motifs found in a variety of upstream kinases, regulating phosphatases and downstream targets. Interactions involving two of these site

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::744b98bf9dbffeb9f3301d01aeae531b
https://europepmc.org/articles/PMC3103835/