Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Olga A. Dravolina"'
Autor:
Alexander A. Spasov, Edwin E. Zvartau, Olesya Iu. Grechko, Natalya V. Eliseeva, Yuliya V. Semenova, Olga A. Dravolina, Pavel M Vasiliev, Vera A. Anisimova
Publikováno v:
Research Results in Pharmacology, Vol 6, Iss 3, Pp 59-65 (2020)
Introduction: The clinical use of kappa-opioid agonists, despite their lack of significant drug potential, is limited by the development of severe sedation, dysphoria, depression, and anhedonia. To this date, there are kappa-opioid receptor agonists
Externí odkaz:
https://doaj.org/article/b89487185e9748449c79f7468ff715bd
Autor:
Edwin Zvartau, Olga A. Dravolina, Alexander A. Spasov, V. A. Anisimova, Olesya Iu. Grechko, Yuliya V. Semenova, Natalya V. Eliseeva, Pavel M Vasiliev
Publikováno v:
Research Results in Pharmacology 6(3): 59-65
Research Results in Pharmacology, Vol 6, Iss 3, Pp 59-65 (2020)
Research Results in Pharmacology, Vol 6, Iss 3, Pp 59-65 (2020)
Introduction: The clinical use of kappa-opioid agonists, despite their lack of significant drug potential, is limited by the development of severe sedation, dysphoria, depression, and anhedonia. To this date, there are kappa-opioid receptor agonists
Publikováno v:
Psychopharmacology. 234:1333-1345
Modulation of the mGlu1 receptor was repeatedly shown to inhibit various phenomena associated with exposure to abused drugs. Efficacy in preclinical models was observed with both positive and negative allosteric modulators (PAMs and NAMs, respectivel
Autor:
Valentina, Vengeliene, Tatiane T, Takahashi, Olga A, Dravolina, Irina, Belozertseva, Edwin, Zvartau, Anton Y, Bespalov, Rainer, Spanagel
Publikováno v:
Psychopharmacology. 235(7)
Preclinical studies suggest that the GABATo test efficacy and adverse effects of baclofen and the novel GABAWe used a well-characterized rat model of long-term alcohol consumption with repeated deprivation phases that result in compulsive alcohol dri
Autor:
Reeta Talka, M. Käenmäki, A. Yu. Bespalov, Olga A. Dravolina, Edwin Zvartau, Pekka T. Männistö, Liudmila Mus, Raimo K. Tuominen, Outi Salminen
Publikováno v:
Neuroscience and Behavioral Physiology. 43:913-917
The effects of catechol-O-methyltransferase deficiency on sensitivity to the reinforcing action of cocaine were studied in male C57BL/6J mice with knockout of the COMT gene and wild-type mice of the same generation. Animals were trained to peep into
Autor:
Marina G. Semina, Irina V Belozertseva, Anton Bespalov, Olga A. Dravolina, Edwin Zvartau, M. A. Tur
Publikováno v:
European journal of pharmacology. 791
Constitutively active 5-HT2 receptors have been suggested to contribute to motoneuronal excitability, muscle spasms and spasticity. Accordingly, 5-HT2C receptor inverse agonists have been demonstrated in pilot experiments to reduce spasticity in anim
Autor:
A. Yu. Bespalov, D. N. Nikolaev, E. E. Yakovleva, L. B. Piotrovskiy, E. V. Litasova, Olga A. Dravolina, M. A. Dumpis
Publikováno v:
Doklady. Biochemistry and biophysics. 468(1)
The present report describes development of hexamethonium complexes based on fullerene C60. Hexamethonium has a limited penetration into CNS and therefore can antagonize central effects of nicotine only when given at high doses. In the present studie
Publikováno v:
Neuroscience and Behavioral Physiology. 40:807-811
Glutamate, the main excitatory neurotransmitter in the mammalian CNS, acts via ionotropic and metabotropic receptors. Results from in vitro studies demonstrating tight interactions between ionotropic NMDA receptors and subtype 5 metabotropic glutamat
Autor:
Elena V. Shekunova, Anton Bespalov, Olga A. Dravolina, Wojciech Danysz, Edwin Zvartau, E. S. Zakharova
Publikováno v:
Neuropharmacology. 52:263-269
Glutamatergic neurotransmission is believed to be critically involved in the acquisition and maintenance of drug addiction. The present study evaluated the role of metabotropic glutamate (mGlu) 1 receptors in the reinstatement of nicotine-seeking beh
Publikováno v:
Brain Research. 1111:48-60
The effects of nicotine, when administered either acutely or chronically, at doses of 0.15, 0.3 or 0.6 mg/kg, on the release of glutamate and arginine in the rat nucleus accumbens have been studied in microdialysis experiments. Glutamate release sign