The Role of SprIR Quorum Sensing System in the Regulation of Serratia proteamaculans 94 Invasion

Autor: Olga Tsaplina, Inessa Khmel, Yulia Zaitseva, Sofia Khaitlina

Publikováno v: Microorganisms, Vol 9, Iss 10, p 2082 (2021)

The bacteria Serratia proteamaculans 94 have a LuxI/LuxR type QS system consisting of AHL synthase SprI and the regulatory receptor SprR. We have previously shown that inactivation of the AHL synthase sprI gene resulted in an increase in the invasive

Externí odkaz: https://doaj.org/article/11cf4c4666034c32b286d0e94d944b4d

Protealysin Targets the Bacterial Housekeeping Proteins FtsZ and RecA

Autor: Olga Tsaplina, Sofia Khaitlina, Ksenia Chukhontseva, Maria Karaseva, Ilya Demidyuk, Irina Bakhlanova, Dmitry Baitin, Tatiana Artamonova, Alexey Vedyaykin, Mikhail Khodorkovskii, Innokentii Vishnyakov

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 18; Pages: 10787

Serratia proteamaculans synthesizes the intracellular metalloprotease protealysin. This work was aimed at searching for bacterial substrates of protealysin among the proteins responsible for replication and cell division. We have shown that protealys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58ee7686c1440236cd3c9bacd1844a7b

Bacterial Outer Membrane Protein OmpX Regulates β1 Integrin and Epidermal Growth Factor Receptor (EGFR) Involved in Invasion of M-HeLa Cells by Serratia proteamaculans

Autor: Olga Tsaplina, Ekaterina Bozhokina

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 22; Issue 24; Pages: 13246
International Journal of Molecular Sciences, Vol 22, Iss 13246, p 13246 (2021)

Opportunistic pathogen Serratia proteamaculans are able to penetrate the eukaryotic cells. The penetration rate can be regulated by bacterial surface protein OmpX. OmpX family proteins are able to bind to host cell surface to the epidermal growth fac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0c861055cd84660e519940837de9dd2
http://europepmc.org/articles/PMC8703988

The Opposite Effects of ROCK and Src Kinase Inhibitors on Susceptibility of Eukaryotic Cells to Invasion by Bacteria Serratia grimesii

Autor: Ekaterina Bozhokina, S. Yu. Khaitlina, Olga Tsaplina

Publikováno v: Biochemistry (Moscow). 84:663-671

Bacterial internalization into eukaryotic cells is ensured by a sophisticated interplay of bacterial and host cell factors. Being a part of cell environment, opportunistic intracellular bacteria have developed various mechanisms providing their inter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08309c209be6b6a569fce46b520e7fd7
https://doi.org/10.1134/s0006297919060099

Bacterial Actin-Specific Endoproteases Grimelysin and Protealysin as Virulence Factors Contributing to the Invasive Activities of Serratia

Autor: Sofia Khaitlina, Ekaterina Bozhokina, T. N. Efremova, Olga Tsaplina

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 4025, p 4025 (2020)
International Journal of Molecular Sciences

The article reviews the discovery, properties and functional activities of new bacterial enzymes, proteases grimelysin (ECP 32) of Serratia grimesii and protealysin of Serratia proteamaculans, characterized by both a highly specific “actinase” ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73f0d755c87f825ddb3344274ccaa8ff
https://www.mdpi.com/1422-0067/21/11/4025