Zobrazeno 1 - 10
of 304
pro vyhledávání: '"Olga, Pletnikova"'
Autor:
Paolo Reho, Sara Saez-Atienzar, Paola Ruffo, Sultana Solaiman, Zalak Shah, Ruth Chia, Karri Kaivola, Bryan J. Traynor, Bension S. Tilley, Steve M. Gentleman, Angela K. Hodges, Dag Aarsland, Edwin S. Monuki, Kathy L. Newell, Randy Woltjer, Marilyn S. Albert, Ted M. Dawson, Liana S. Rosenthal, Juan C. Troncoso, Olga Pletnikova, Geidy E. Serrano, Thomas G. Beach, Hariharan P. Easwaran, Sonja W. Scholz
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract Dementia with Lewy bodies (DLB) is a common form of dementia in the elderly population. We performed genome-wide DNA methylation mapping of cerebellar tissue from pathologically confirmed DLB cases and controls to study the epigenetic profil
Externí odkaz:
https://doaj.org/article/1f5a47a3a95d4835830f83e30874d417
Autor:
Yiyao Huang, Tanina Arab, Ashley E. Russell, Emily R. Mallick, Rajini Nagaraj, Evan Gizzie, Javier Redding‐Ochoa, Juan C. Troncoso, Olga Pletnikova, Andrey Turchinovich, David A. Routenberg, Kenneth W. Witwer
Publikováno v:
Interdisciplinary Medicine, Vol 1, Iss 4, Pp n/a-n/a (2023)
Abstract Extracellular vesicles (EVs) are released from different cell types in the central nervous system (CNS) and play roles in regulating physiological and pathological functions. Although brain‐derived EVs (bdEVs) have been successfully collec
Externí odkaz:
https://doaj.org/article/1f8dd20d4e9c4d5cbb2131ee404424d1
Autor:
Meaghan Morris, Abhay Moghekar, Haidan Guo, Olga Pletnikova, Javier Redding-Ochoa, Marilyn Albert, Susan M. Resnick, Liam Chen
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-4 (2022)
Abstract Several neurodegenerative pathologies can clinically mimic Parkinson’s disease, including neurodegenerative diseases with glial pathology. However, the glial aggregates are typically composed of known pathogenic proteins and are associated
Externí odkaz:
https://doaj.org/article/c1ca515f46864a67989a09b91fecc3e8
Autor:
Yura Jang, Thujitha Thuraisamy, Javier Redding‐Ochoa, Olga Pletnikova, Juan C. Troncoso, Zhen Zhang, Liana S. Rosenthal, Ted M. Dawson, Alexander Y. Pantelyat, Chan Hyun Na
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 11, Pp n/a-n/a (2022)
Abstract Background Progressive supranuclear palsy (PSP) is a neurodegenerative disorder clinically characterized by progressive postural instability, supranuclear gaze palsy, parkinsonism, and cognitive decline caused by degeneration in specific are
Externí odkaz:
https://doaj.org/article/5e0d29f74f0049ad92e603b339602920
Autor:
Vijay R. Varma, H. Büşra Lüleci, Anup M. Oommen, Sudhir Varma, Chad T. Blackshear, Michael E. Griswold, Yang An, Jackson A. Roberts, Richard O’Brien, Olga Pletnikova, Juan C. Troncoso, David A. Bennett, Tunahan Çakır, Cristina Legido-Quigley, Madhav Thambisetty
Publikováno v:
npj Aging and Mechanisms of Disease, Vol 7, Iss 1, Pp 1-14 (2021)
Abstract The role of brain cholesterol metabolism in Alzheimer’s disease (AD) remains unclear. Peripheral and brain cholesterol levels are largely independent due to the impermeability of the blood brain barrier (BBB), highlighting the importance o
Externí odkaz:
https://doaj.org/article/9b5faa98d6754c758ecbe26dd59288c8
Autor:
Jong-Sung Park, Tae-In Kam, Saebom Lee, Hyejin Park, Yumin Oh, Seung-Hwan Kwon, Jae-Jin Song, Donghoon Kim, Hyunhee Kim, Aanishaa Jhaldiyal, Dong Hee Na, Kang Choon Lee, Eun Ji Park, Martin G. Pomper, Olga Pletnikova, Juan C. Troncoso, Han Seok Ko, Valina L. Dawson, Ted M. Dawson, Seulki Lee
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-15 (2021)
Abstract Alzheimer’s disease (AD) is the most common cause of age-related dementia. Increasing evidence suggests that neuroinflammation mediated by microglia and astrocytes contributes to disease progression and severity in AD and other neurodegene
Externí odkaz:
https://doaj.org/article/8c12a20bbf914cb084511984a12e33ad
Autor:
Kateryna Murlanova, Yan Jouroukhin, Ksenia Novototskaya-Vlasova, Shovgi Huseynov, Olga Pletnikova, Michael J. Morales, Yun Guan, Atsushi Kamiya, Dwight E. Bergles, David M. Dietz, Mikhail V. Pletnikov
Publikováno v:
Cells, Vol 12, Iss 10, p 1412 (2023)
Astrocytes express mu/µ opioid receptors, but the function of these receptors remains poorly understood. We evaluated the effects of astrocyte-restricted knockout of µ opioid receptors on reward- and aversion-associated behaviors in mice chronicall
Externí odkaz:
https://doaj.org/article/26d7ea31e0aa4d55a6b9ddc5ba3e91bc
Autor:
Md. Razaul Karim, Elly E. Liao, Jaekwang Kim, Joyce Meints, Hector Martell Martinez, Olga Pletnikova, Juan C. Troncoso, Michael K. Lee
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-18 (2020)
Abstract Background Studies link c-Abl activation with the accumulation of pathogenic α-synuclein (αS) and neurodegeneration in Parkinson’s disease (PD). Currently, c-Abl, a tyrosine kinase activated by cellular stress, is thought to promote αS
Externí odkaz:
https://doaj.org/article/487df58d116947c79351cf1ed5aeac59
Autor:
Marya S. Sabir, Cornelis Blauwendraat, Sarah Ahmed, Geidy E. Serrano, Thomas G. Beach, Matthew Perkins, Ann C. Rice, Eliezer Masliah, Christopher M. Morris, Lasse Pihlstrom, Alexander Pantelyat, Susan M. Resnick, Mark R. Cookson, Dena G. Hernandez, Marilyn Albert, Ted M. Dawson, Liana S. Rosenthal, Henry Houlden, Olga Pletnikova, Juan Troncoso, Sonja W. Scholz
Publikováno v:
Neurobiology of Disease, Vol 127, Iss , Pp 142-146 (2019)
Atypical parkinsonism syndromes are a heterogeneous group of neurodegenerative disorders that include corticobasal degeneration (CBD), Lewy body dementia (LBD), multiple system atrophy (MSA), and progressive supranuclear palsy (PSP). The APOE ε4 all
Externí odkaz:
https://doaj.org/article/0b8f2037e2114d4bbffc089f1591cb20
Autor:
Rita Guerreiro, Valentina Escott-Price, Dena G. Hernandez, Celia Kun-Rodrigues, Owen A. Ross, Tatiana Orme, Joao Luis Neto, Susana Carmona, Nadia Dehghani, John D. Eicher, Claire Shepherd, Laura Parkkinen, Lee Darwent, Michael G. Heckman, Sonja W. Scholz, Juan C. Troncoso, Olga Pletnikova, Ted Dawson, Liana Rosenthal, Olaf Ansorge, Jordi Clarimon, Alberto Lleo, Estrella Morenas-Rodriguez, Lorraine Clark, Lawrence S. Honig, Karen Marder, Afina Lemstra, Ekaterina Rogaeva, Peter St. George-Hyslop, Elisabet Londos, Henrik Zetterberg, Imelda Barber, Anne Braae, Kristelle Brown, Kevin Morgan, Claire Troakes, Safa Al-Sarraj, Tammaryn Lashley, Janice Holton, Yaroslau Compta, Vivianna Van Deerlin, Geidy E. Serrano, Thomas G. Beach, Suzanne Lesage, Douglas Galasko, Eliezer Masliah, Isabel Santana, Pau Pastor, Monica Diez-Fairen, Miquel Aguilar, Pentti J. Tienari, Liisa Myllykangas, Minna Oinas, Tamas Revesz, Andrew Lees, Brad F. Boeve, Ronald C. Petersen, Tanis J. Ferman, Neill Graff-Radford, Nigel J. Cairns, John C. Morris, Stuart Pickering-Brown, David Mann, Glenda M. Halliday, John Hardy, John Q. Trojanowski, Dennis W. Dickson, Andrew Singleton, David J. Stone, Jose Bras
Publikováno v:
Neurobiology of Disease, Vol 127, Iss , Pp 492-501 (2019)
Recent large-scale genetic studies have allowed for the first glimpse of the effects of common genetic variability in dementia with Lewy bodies (DLB), identifying risk variants with appreciable effect sizes. However, it is currently well established
Externí odkaz:
https://doaj.org/article/8a8a606f7f4c49d690647ef64ba97f82