Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Olga, Murina"'
Autor:
Lorenza P. Ferretti, Sarah-Felicitas Himmels, Anika Trenner, Christina Walker, Christine von Aesch, Aline Eggenschwiler, Olga Murina, Radoslav I. Enchev, Matthias Peter, Raimundo Freire, Antonio Porro, Alessandro A. Sartori
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
CtIP has a key role in DNA double-strand break repair as its role in resecting DNA at the break commits a cell to homologous recombination. Here the authors show that KLHL15 interacts with CtIP and regulates repair by controlling protein turnover.
Externí odkaz:
https://doaj.org/article/205a013d59044243b694ef6cde84318a
Autor:
Valerie G. Brunton, Adam Byron, Andrew H. Sims, Asier Unciti-Broceta, Morwenna Muir, Jayne Culley, Carolin Temps, David A. Parry, Alexander E.P. Loftus, Olga Murina, Billie G.C. Griffith, Henry Beetham
SRC is a nonreceptor tyrosine kinase with key roles in breast cancer development and progression. Despite this, SRC tyrosine kinase inhibitors have so far failed to live up to their promise in clinical trials, with poor overall response rates. We aim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4232d73c826f1846f5b843e4526d96f7
https://doi.org/10.1158/0008-5472.c.6513523.v1
https://doi.org/10.1158/0008-5472.c.6513523.v1
Autor:
Valerie G. Brunton, Adam Byron, Andrew H. Sims, Asier Unciti-Broceta, Morwenna Muir, Jayne Culley, Carolin Temps, David A. Parry, Alexander E.P. Loftus, Olga Murina, Billie G.C. Griffith, Henry Beetham
Supplementary Figure from Loss of Integrin-Linked Kinase Sensitizes Breast Cancer to SRC Inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ac2321e4c5ebd700f7f961f6fc0ceef
https://doi.org/10.1158/0008-5472.22430041.v1
https://doi.org/10.1158/0008-5472.22430041.v1
Autor:
Valerie G. Brunton, Adam Byron, Andrew H. Sims, Asier Unciti-Broceta, Morwenna Muir, Jayne Culley, Carolin Temps, David A. Parry, Alexander E.P. Loftus, Olga Murina, Billie G.C. Griffith, Henry Beetham
Supplementary Data from Loss of Integrin-Linked Kinase Sensitizes Breast Cancer to SRC Inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ae7a4ca1ea41e4bb2ff29dd30e2669e
https://doi.org/10.1158/0008-5472.22430050.v1
https://doi.org/10.1158/0008-5472.22430050.v1
Autor:
Olga Murina, Christine von Aesch, Ufuk Karakus, Lorenza P. Ferretti, Hella A. Bolck, Kay Hänggi, Alessandro A. Sartori
Publikováno v:
Cell Reports, Vol 7, Iss 4, Pp 1030-1038 (2014)
The resolution of DNA interstrand crosslinks (ICLs) requires a complex interplay between several processes of DNA metabolism, including the Fanconi anemia (FA) pathway and homologous recombination (HR). FANCD2 monoubiquitination and CtIP-dependent DN
Externí odkaz:
https://doaj.org/article/988e5ca39e1a4d99a128e310b7eac278
Autor:
Henry Beetham, Billie G.C. Griffith, Olga Murina, Alexander E.P. Loftus, David A. Parry, Carolin Temps, Jayne Culley, Morwenna Muir, Asier Unciti-Broceta, Andrew H. Sims, Adam Byron, Valerie G. Brunton
Publikováno v:
Beetham, H, Griffith, B, Murina, O, Loftus, A, Parry, D A, Temps, C, Culley, J, Muir, M, Unciti-Broceta, A, Sims, A H, Byron, A & Brunton, V G 2021, ' Loss of Integrin-linked kinase sensitizes breast cancer to SRC inhibitors ', Cancer Research . https://doi.org/10.1158/0008-5472.CAN-21-0373
Beetham, H, Griffith, B G C, Murina, O, Loftus, A E P, Parry, D A, Temps, C, Culley, J, Muir, M, Unciti-Broceta, A, Sims, A H, Byron, A & Brunton, V G 2022, ' Loss of Integrin-linked kinase sensitizes breast cancer to SRC inhibitors ', Cancer Research, vol. 82, no. 4, pp. 632-647 . https://doi.org/10.1158/0008-5472.CAN-21-0373
Beetham, H, Griffith, B G C, Murina, O, Loftus, A E P, Parry, D A, Temps, C, Culley, J, Muir, M, Unciti-Broceta, A, Sims, A H, Byron, A & Brunton, V G 2022, ' Loss of Integrin-linked kinase sensitizes breast cancer to SRC inhibitors ', Cancer Research, vol. 82, no. 4, pp. 632-647 . https://doi.org/10.1158/0008-5472.CAN-21-0373
SRC is a nonreceptor tyrosine kinase with key roles in breast cancer development and progression. Despite this, SRC tyrosine kinase inhibitors have so far failed to live up to their promise in clinical trials, with poor overall response rates. We aim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e60490b72d4b6e9896c2cb3f20e716f6
https://www.pure.ed.ac.uk/ws/files/245549967/Loss_of_Integrin_linked_kinase_sensitizes_breast_cancer_to_SRC_inhibitors_published_AAM.pdf
https://www.pure.ed.ac.uk/ws/files/245549967/Loss_of_Integrin_linked_kinase_sensitizes_breast_cancer_to_SRC_inhibitors_published_AAM.pdf
Autor:
Andrea McEwan, Megha Chandrashekhar, Olga Murina, Maryou B. Lambros, Valerie G. Brunton, Daniel Durocher, Angelo Agathanggelou, Martin A M Reijns, Jason Moffat, Tatjana Stankovic, Michal Zimmermann, Stephane Angers, Traver Hart, Adeline Fluteau, Michael Aregger, Paul Moss, Morwenna Muir, Wei Yuan, Rachel C. Challis, Matthew Clarke, Andrew P. Jackson, Shankara Paneesha, Johann S. de Bono, Žygimantė Tarnauskaitė
Publikováno v:
Zimmermann, M, Murina, O, Reijns, M A M, Agathanggelou, A, Challis, R, Tarnauskaite, Z, Muir, M, Fluteau, A, Aregger, M, McEwan, A, Yuan, W, Clarke, M, Lambros, M B, Paneesha, S, Moss, P, Chandrashekhar, M, Angers, S, Moffat, J, Brunton, V G, Hart, T, de Bono, J, Stankovic, T, Jackson, A P & Durocher, D 2019, ' CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions ', Nature, vol. 559, no. 7713, pp. 285–289 . https://doi.org/10.1038/s41586-018-0291-z
The observation that BRCA1- and BRCA2-deficient cells are sensitive to inhibitors of poly(ADP–ribose) polymerase (PARP) has spurred the development of cancer therapies that use these inhibitors to target deficiencies in homologous recombination. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c31459b4e5a8c1168b596ef85f70c55
https://doi.org/10.1038/s41586-018-0291-z
https://doi.org/10.1038/s41586-018-0291-z
Autor:
Andrew P. Jackson, Martin A M Reijns, Louise S. Bicknell, Žygimantė Tarnauskaitė, Jennie E. Murray, Angela L. Duker, Carol Wise, David Sillence, Michael B. Bober, Clare V. Logan, Deepthi De Silva, David A. Parry, Joseph A. Marsh, Olga Murina
Publikováno v:
Human Mutation
Tarnauskaitė, Ž, Bicknell, L S, Marsh, J A, Murray, J E, Parry, D A, Logan, C V, Bober, M B, de Silva, D C, Duker, A L, Sillence, D, Wise, C, Jackson, A P, Murina, O & Reijns, M A M 2019, ' Biallelic variants in DNA2 cause microcephalic primordial dwarfism ', Human Mutation, vol. 40, no. 8, pp. 1063-1070 . https://doi.org/10.1002/humu.23776
Tarnauskaitė, Ž, Bicknell, L S, Marsh, J A, Murray, J E, Parry, D A, Logan, C V, Bober, M B, de Silva, D C, Duker, A L, Sillence, D, Wise, C, Jackson, A P, Murina, O & Reijns, M A M 2019, ' Biallelic variants in DNA2 cause microcephalic primordial dwarfism ', Human Mutation, vol. 40, no. 8, pp. 1063-1070 . https://doi.org/10.1002/humu.23776
Microcephalic primordial dwarfism (MPD) is a group of rare single‐gene disorders characterized by the extreme reduction in brain and body size from early development onwards. Proteins encoded by MPD‐associated genes play important roles in fundam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed9832e61145ae2176f89f8894dccdf3
Autor:
Sarah-Felicitas Himmels, Antonio Porro, Matthias Peter, Raimundo Freire, Alessandro A. Sartori, Christina Walker, Olga Murina, Aline Eggenschwiler, Lorenza P. Ferretti, Radoslav I. Enchev, Christine von Aesch, Anika Trenner
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
Ferretti, L P, Himmels, S-F, Trenner, A, Walker, C, von Aesch, C, Eggenschwiler, A, Murina, O, Enchev, R I, Peter, M, Freire, R, Porro, A & Sartori, A A 2016, ' Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection ', Nature Communications, vol. 7, pp. 12628 . https://doi.org/10.1038/ncomms12628
Nature Communications, 7
Nature Communications
Ferretti, L P, Himmels, S-F, Trenner, A, Walker, C, von Aesch, C, Eggenschwiler, A, Murina, O, Enchev, R I, Peter, M, Freire, R, Porro, A & Sartori, A A 2016, ' Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection ', Nature Communications, vol. 7, pp. 12628 . https://doi.org/10.1038/ncomms12628
Nature Communications, 7
Nature Communications
Human CtIP is a decisive factor in DNA double-strand break repair pathway choice by enabling DNA-end resection, the first step that differentiates homologous recombination (HR) from non-homologous end-joining (NHEJ). To coordinate appropriate and tim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36dd6af941fc34b9d8140e4ab6963b9d
https://doaj.org/article/205a013d59044243b694ef6cde84318a
https://doaj.org/article/205a013d59044243b694ef6cde84318a
Autor:
Lynn Greenhalgh, Janine Altmüller, Bernd Wollnik, Gökhan Yigit, Michael B. Bober, Sarah McGlasson, Andrew N. Blackford, Louise S. Bicknell, Matthew E. Hurles, Holger Thiele, Peter Nürnberg, Carol Anne Martin, Karen J. Mackenzie, Kaalak Reddy, Andrea Leitch, Grant S. Stewart, Margaret E. Harley, Luciana Chessa, Adeline Fluteau, Stephen P. Jackson, Martin R. Higgs, Olga Murina, Mihail Halachev, Martin A M Reijns, Simone Sabbioneda, Mahmoud Salim, Anastasia Zlatanou, Nursel Elcioglu, Andrew P. Jackson, Mohamad Maghnie
Publikováno v:
Nature genetics
Harley, M E, Murina, O, Leitch, A, Higgs, M, Bicknell, L S, Yigit, G, Blackford, A, Zlatanou, A, Mackenzie, K J, Reddy, K, Halachev, M, McGlasson, S, Reijns, M A M, Fluteau, A, Martin, C-A, Sabbioneda, S, Elcioglu, N H, Altmuller, J, Thiele, H, Greenhalgh, L, Chessa, L, Maghnie, M, Salim, M, Bober, M B, Nurnberg, P, Jackson, S P, Hurles, M E, Wollnik, B, Stewart, G S & Jackson, A P 2016, ' TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism ', Nature Genetics, vol. 48, no. 1, pp. 36-43 . https://doi.org/10.1038/ng.3451
Harley, M E, Murina, O, Leitch, A, Higgs, M, Bicknell, L S, Yigit, G, Blackford, A, Zlatanou, A, Mackenzie, K J, Reddy, K, Halachev, M, McGlasson, S, Reijns, M A M, Fluteau, A, Martin, C-A, Sabbioneda, S, Elcioglu, N H, Altmuller, J, Thiele, H, Greenhalgh, L, Chessa, L, Maghnie, M, Salim, M, Bober, M B, Nurnberg, P, Jackson, S P, Hurles, M E, Wollnik, B, Stewart, G S & Jackson, A P 2016, ' TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism ', Nature Genetics, vol. 48, no. 1, pp. 36-43 . https://doi.org/10.1038/ng.3451
DNA lesions encountered by replicative polymerases threaten genome stability and cell cycleprogression. Here we report the identification of mutations in TRAIP, encoding an E3 RING ubiquitinligase, in patients with microcephalic primordial dwarfism/S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42cde41bd5505ee27973df43b1ce1a0d
https://doi.org/10.1038/ng.3451
https://doi.org/10.1038/ng.3451