Data from Loss of Integrin-Linked Kinase Sensitizes Breast Cancer to SRC Inhibitors

Autor: Valerie G. Brunton, Adam Byron, Andrew H. Sims, Asier Unciti-Broceta, Morwenna Muir, Jayne Culley, Carolin Temps, David A. Parry, Alexander E.P. Loftus, Olga Murina, Billie G.C. Griffith, Henry Beetham

SRC is a nonreceptor tyrosine kinase with key roles in breast cancer development and progression. Despite this, SRC tyrosine kinase inhibitors have so far failed to live up to their promise in clinical trials, with poor overall response rates. We aim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4232d73c826f1846f5b843e4526d96f7
https://doi.org/10.1158/0008-5472.c.6513523.v1

Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection

Autor: Lorenza P. Ferretti, Sarah-Felicitas Himmels, Anika Trenner, Christina Walker, Christine von Aesch, Aline Eggenschwiler, Olga Murina, Radoslav I. Enchev, Matthias Peter, Raimundo Freire, Antonio Porro, Alessandro A. Sartori

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)

CtIP has a key role in DNA double-strand break repair as its role in resecting DNA at the break commits a cell to homologous recombination. Here the authors show that KLHL15 interacts with CtIP and regulates repair by controlling protein turnover.

Externí odkaz: https://doaj.org/article/205a013d59044243b694ef6cde84318a

Loss of Integrin-linked kinase sensitizes breast cancer to SRC inhibitors

Autor: Henry Beetham, Billie G.C. Griffith, Olga Murina, Alexander E.P. Loftus, David A. Parry, Carolin Temps, Jayne Culley, Morwenna Muir, Asier Unciti-Broceta, Andrew H. Sims, Adam Byron, Valerie G. Brunton

Publikováno v: Beetham, H, Griffith, B, Murina, O, Loftus, A, Parry, D A, Temps, C, Culley, J, Muir, M, Unciti-Broceta, A, Sims, A H, Byron, A & Brunton, V G 2021, ' Loss of Integrin-linked kinase sensitizes breast cancer to SRC inhibitors ', Cancer Research . https://doi.org/10.1158/0008-5472.CAN-21-0373
Beetham, H, Griffith, B G C, Murina, O, Loftus, A E P, Parry, D A, Temps, C, Culley, J, Muir, M, Unciti-Broceta, A, Sims, A H, Byron, A & Brunton, V G 2022, ' Loss of Integrin-linked kinase sensitizes breast cancer to SRC inhibitors ', Cancer Research, vol. 82, no. 4, pp. 632-647 . https://doi.org/10.1158/0008-5472.CAN-21-0373

SRC is a nonreceptor tyrosine kinase with key roles in breast cancer development and progression. Despite this, SRC tyrosine kinase inhibitors have so far failed to live up to their promise in clinical trials, with poor overall response rates. We aim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e60490b72d4b6e9896c2cb3f20e716f6
https://www.pure.ed.ac.uk/ws/files/245549967/Loss_of_Integrin_linked_kinase_sensitizes_breast_cancer_to_SRC_inhibitors_published_AAM.pdf

Biallelic variants in DNA2 cause microcephalic primordial dwarfism

Autor: Andrew P. Jackson, Martin A M Reijns, Louise S. Bicknell, Žygimantė Tarnauskaitė, Jennie E. Murray, Angela L. Duker, Carol Wise, David Sillence, Michael B. Bober, Clare V. Logan, Deepthi De Silva, David A. Parry, Joseph A. Marsh, Olga Murina

Publikováno v: Human Mutation
Tarnauskaitė, Ž, Bicknell, L S, Marsh, J A, Murray, J E, Parry, D A, Logan, C V, Bober, M B, de Silva, D C, Duker, A L, Sillence, D, Wise, C, Jackson, A P, Murina, O & Reijns, M A M 2019, ' Biallelic variants in DNA2 cause microcephalic primordial dwarfism ', Human Mutation, vol. 40, no. 8, pp. 1063-1070 . https://doi.org/10.1002/humu.23776

Microcephalic primordial dwarfism (MPD) is a group of rare single‐gene disorders characterized by the extreme reduction in brain and body size from early development onwards. Proteins encoded by MPD‐associated genes play important roles in fundam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed9832e61145ae2176f89f8894dccdf3

TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism

Autor: Lynn Greenhalgh, Janine Altmüller, Bernd Wollnik, Gökhan Yigit, Michael B. Bober, Sarah McGlasson, Andrew N. Blackford, Louise S. Bicknell, Matthew E. Hurles, Holger Thiele, Peter Nürnberg, Carol Anne Martin, Karen J. Mackenzie, Kaalak Reddy, Andrea Leitch, Grant S. Stewart, Margaret E. Harley, Luciana Chessa, Adeline Fluteau, Stephen P. Jackson, Martin R. Higgs, Olga Murina, Mihail Halachev, Martin A M Reijns, Simone Sabbioneda, Mahmoud Salim, Anastasia Zlatanou, Nursel Elcioglu, Andrew P. Jackson, Mohamad Maghnie

Publikováno v: Nature genetics
Harley, M E, Murina, O, Leitch, A, Higgs, M, Bicknell, L S, Yigit, G, Blackford, A, Zlatanou, A, Mackenzie, K J, Reddy, K, Halachev, M, McGlasson, S, Reijns, M A M, Fluteau, A, Martin, C-A, Sabbioneda, S, Elcioglu, N H, Altmuller, J, Thiele, H, Greenhalgh, L, Chessa, L, Maghnie, M, Salim, M, Bober, M B, Nurnberg, P, Jackson, S P, Hurles, M E, Wollnik, B, Stewart, G S & Jackson, A P 2016, ' TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism ', Nature Genetics, vol. 48, no. 1, pp. 36-43 . https://doi.org/10.1038/ng.3451

DNA lesions encountered by replicative polymerases threaten genome stability and cell cycleprogression. Here we report the identification of mutations in TRAIP, encoding an E3 RING ubiquitinligase, in patients with microcephalic primordial dwarfism/S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42cde41bd5505ee27973df43b1ce1a0d
https://doi.org/10.1038/ng.3451