Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Olga, Krupkova"'
Autor:
Thomas Bitterli, David Schmid, Ladina Ettinger, Olga Krupkova, Frances C. Bach, Marianna A. Tryfonidou, Björn P. Meij, Antonio Pozzi, Frank Steffen, Karin Wuertz‐Kozak, Lucas A. Smolders
Publikováno v:
JOR Spine, Vol 7, Iss 1, Pp n/a-n/a (2024)
Abstract Background The regulation of inflammatory mediators in the degenerating intervertebral disc (IVD) and corresponding ligamentum flavum (LF) is a topic of emerging interest. The study aimed to investigate the expression of a broad array of inf
Externí odkaz:
https://doaj.org/article/a0130bc574964e6baf2eee7b83f54b28
Autor:
Jesil Kasamkattil, Anna Gryadunova, Raphael Schmid, Max Hans Peter Gay-Dujak, Boris Dasen, Morgane Hilpert, Karoliina Pelttari, Ivan Martin, Stefan Schären, Andrea Barbero, Olga Krupkova, Arne Mehrkens
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
Introduction: An in vitro model that appropriately recapitulates the degenerative disc disease (DDD) microenvironment is needed to explore clinically relevant cell-based therapeutic strategies for early-stage degenerative disc disease. We developed a
Externí odkaz:
https://doaj.org/article/4653c0ae89024f3f8db685efa9865690
Autor:
Andrea Mainardi, Elena Cambria, Paola Occhetta, Ivan Martin, Andrea Barbero, Stefan Schären, Arne Mehrkens, Olga Krupkova
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 9 (2022)
Discogenic back pain is one of the most diffused musculoskeletal pathologies and a hurdle to a good quality of life for millions of people. Existing therapeutic options are exclusively directed at reducing symptoms, not at targeting the underlying, s
Externí odkaz:
https://doaj.org/article/315d63e15b7240869a664d72a942386b
This volume contains invited lectures and selected research papers in the fields of classical and modern differential geometry, global analysis, and geometric methods in physics, presented at the 10th International Conference on Differential Geometry
Autor:
Elena Cambria, Matthias J. E. Arlt, Sandra Wandel, Olga Krupkova, Wolfgang Hitzl, Fabian S. Passini, Oliver N. Hausmann, Jess G. Snedeker, Stephen J. Ferguson, Karin Wuertz-Kozak
Publikováno v:
Cells, Vol 9, Iss 7, p 1736 (2020)
Mechanical loading and inflammation interact to cause degenerative disc disease and low back pain (LBP). However, the underlying mechanosensing and mechanotransductive pathways are poorly understood. This results in untargeted pharmacological treatme
Externí odkaz:
https://doaj.org/article/55ba19fd9cee4acc986df1334826d34c
Autor:
Olga Krupkova, Aleksandra Sadowska, Takuya Kameda, Wolfgang Hitzl, Oliver Nic Hausmann, Juergen Klasen, Karin Wuertz-Kozak
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Degenerative disc disease is associated with increased expression of pro-inflammatory cytokines in the intervertebral disc (IVD). However, it is not completely clear how inflammation arises in the IVD and which cellular compartments are involved in t
Externí odkaz:
https://doaj.org/article/bd2414a94bae4ef8a6da79bb4bcaa3bc
Publikováno v:
Frontiers in Veterinary Science, Vol 5 (2018)
Serious knee pain and related disability have an annual prevalence of approximately 25% on those over the age of 55 years. As curative treatments for the common knee problems are not available to date, knee pathologies typically progress and often le
Externí odkaz:
https://doaj.org/article/120dc8ae5bd342438bcb5b55e3528d98
Publikováno v:
JOR Spine, Vol 1, Iss 1, Pp n/a-n/a (2018)
The CRISPR/Cas9 system has emerged as a powerful tool for mammalian genome engineering. In basic and translational intervertebral disc (IVD) research, this technique has remarkable potential to answer fundamental questions on pathway interactions, to
Externí odkaz:
https://doaj.org/article/51074e4186864c26b4a94b0a5469daa5
Autor:
Moira Loepfe, Anja Duss, Katerina-Alexandra Zafeiropoulou, Oddny Björgvinsdóttir, Matteo D’Este, David Eglin, Giuseppino Fortunato, Juergen Klasen, Stephen J. Ferguson, Karin Wuertz-Kozak, Olga Krupkova
Publikováno v:
Pharmaceutics, Vol 11, Iss 9, p 435 (2019)
Locally delivered anti-inflammatory compounds can restore the homeostasis of the degenerated intervertebral disc (IVD). With beneficial effects on IVD cells, epigallocatechin 3-gallate (EGCG) is a promising therapeutic candidate. However, EGCG is pro
Externí odkaz:
https://doaj.org/article/e8cd13f21340474a97a1c772ee1db9cd
Autor:
Vikas Mathew, Manuela Boos, Simona Capossela, Alessandro Bertolo, Olga Krupkova, Jivko Stoyanov
Publikováno v:
Drug Design, Development and Therapy. 14:4547-4560
Purpose The production of nano-erythrosomes (NEs) by extrusion, which is considered the "gold standard", has several disadvantages such as difficult equipment assembly, long procedure time, variable pressure, and problems with sterility. An alternati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fac2c0c19649123c15428988ecf74f9
https://doi.org/10.2147/dddt.s258368
https://doi.org/10.2147/dddt.s258368