Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Olga, Khersonsky"'
Autor:
Pascal D. Vos, Giulia Rossetti, Jessica L. Mantegna, Stefan J. Siira, Andrianto P. Gandadireja, Mitchell Bruce, Samuel A. Raven, Olga Khersonsky, Sarel J. Fleishman, Aleksandra Filipovska, Oliver Rackham
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
The ability to alter the genomes of living cells is key to understanding how genes influence the functions of organisms and will be critical to modify living systems for useful purposes. Here, the authors use computational design to discover Cas9 enz
Externí odkaz:
https://doaj.org/article/42738fae0b8a437eab42e9af9c83d4ca
Autor:
Olga Khersonsky, Sarel J. Fleishman
Publikováno v:
BioDesign Research, Vol 2022 (2022)
The overarching goal of computational protein design is to gain complete control over protein structure and function. The majority of sophisticated binders and enzymes, however, are large and exhibit diverse and complex folds that defy atomistic desi
Externí odkaz:
https://doaj.org/article/70858688440c450cbd3ae6145a9f6c2a
Autor:
Gideon Lapidoth, Olga Khersonsky, Rosalie Lipsh, Orly Dym, Shira Albeck, Shelly Rogotner, Sarel J. Fleishman
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Computationally designed enzymes often show lower activity or stability than their natural counterparts. Here, the authors present an evolution-inspired method for automated enzyme design, creating stable enzymes with accurate active site architectur
Externí odkaz:
https://doaj.org/article/e6f62792433646fab21959e1b02b0675
Autor:
Hyla Allouche-Arnon, Olga Khersonsky, Nishanth D. Tirukoti, Yoav Peleg, Orly Dym, Shira Albeck, Alexander Brandis, Tevie Mehlman, Liat Avram, Talia Harris, Nirbhay N. Yadav, Sarel J. Fleishman, Amnon Bar-Shir
Publikováno v:
Nature Biotechnology
Imaging of gene-expression patterns in live animals is difficult to achieve with fluorescent proteins because tissues are opaque to visible light. Imaging of transgene expression with magnetic resonance imaging (MRI), which penetrates to deep tissues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a7685c8536830596d712a6a4e3a8d09
https://doi.org/10.1038/s41587-021-01162-5
https://doi.org/10.1038/s41587-021-01162-5
Autor:
Olga Khersonsky, Moshe Goldsmith, Irina Zaretsky, Shelly Rogotner, Orly Dym, Tamar Unger, Meital Yona, Sarel J. Fleishman
Albumin is the most abundant protein in the blood serum of mammals and has essential carrier and physiological roles. Albumins are also used in a wide variety of molecular and cellular experiments and in the cultured-meat industry. Despite their impo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::959f51fe969ca34576e6d78ee1df7e4b
https://doi.org/10.1101/2023.03.28.534334
https://doi.org/10.1101/2023.03.28.534334
Autor:
Sarka Pokorna, Olga Khersonsky, Rosalie Lipsh‐Sokolik, Adi Goldenzweig, Rebekka Nielsen, Yacov Ashani, Yoav Peleg, Tamar Unger, Shira Albeck, Orly Dym, Asa Tirosh, Rana Tarayra, Michaël Hocquemiller, Ralph Laufer, Shifra Ben‐Dor, Israel Silman, Joel L. Sussman, Sarel J. Fleishman, Anthony H. Futerman
Publikováno v:
The FEBS Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8aca0f282f8a57026dfc6c8e11be59f
https://doi.org/10.1111/febs.16758
https://doi.org/10.1111/febs.16758
Autor:
null Sarka Pokorna, null Olga Khersonsky, null Rosalie Lipsh‐Sokolik, null Adi Goldenzweig, null Rebekka Nielsen, null Yacov Ashani, null Yoav Peleg, null Tamar Unger, null Shira Albeck, null Orly Dym, null Asa Tirosh, null Rana Tarayra, null Michaël Hocquemiller, null Ralph Laufer, null Shifra Ben‐Dor, null Israel Silman, null Joel L. Sussman, null Sarel J. Fleishman, null Anthony H. Futerman
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e00b62895e63a5c64c1ba12b351bfbf
https://doi.org/10.1111/febs.16758/v2/response1
https://doi.org/10.1111/febs.16758/v2/response1
Autor:
Sarel J. Fleishman, Hiromu Monai, Björn Breithausen, Vanessa Vongsouthi, Leon Kremers, Joshua A. Mitchell, Christian Henneberger, Harald Janovjak, Petr Unichenko, Colin J. Jackson, Jason H. Whitfield, Hajime Hirase, Olga Khersonsky
Publikováno v:
ACS Sensors
ACS sensors 6(11), 4193-4205 (2021). doi:10.1021/acssensors.1c01803
ACS sensors 6(11), 4193-4205 (2021). doi:10.1021/acssensors.1c01803
Solute-binding proteins (SBPs) have evolved to balance the demands of ligand affinity, thermostability, and conformational change to accomplish diverse functions in small molecule transport, sensing, and chemotaxis. Although the ligand-induced confor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ef75e69db29bdc2bb3ed864f4b98c13
https://doi.org/10.1021/acssensors.1c01803
https://doi.org/10.1021/acssensors.1c01803
Autor:
Rosalie Lipsh-Sokolik, Olga Khersonsky, Sybrin P. Schröder, Casper de Boer, Shlomo-Yakir Hoch, Gideon J. Davies, Hermen S. Overkleeft, Sarel J. Fleishman
Design of structurally diverse enzymes is constrained by long-range interactions that are needed for accurate folding. We introduce an atomistic and machine-learning strategy for Combinatorial Assembly and Design of ENZymes, CADENZ, to design fragmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed562448256abf5d3b2f69836f27cff7
https://doi.org/10.1101/2022.09.17.508230
https://doi.org/10.1101/2022.09.17.508230
Autor:
Chelsey M, VanDrisse, Rosalie, Lipsh-Sokolik, Olga, Khersonsky, Sarel J, Fleishman, Dianne K, Newman
Publikováno v:
Proc Natl Acad Sci U S A
Pseudomonas aeruginosa is an opportunistic human pathogen that develops difficult-to-treat biofilms in immunocompromised individuals, cystic fibrosis patients, and in chronic wounds. P. aeruginosa has an arsenal of physiological attributes that enabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::44d5becd22e0750920a5a6e7cab9fddb
https://pubmed.ncbi.nlm.nih.gov/33723058
https://pubmed.ncbi.nlm.nih.gov/33723058