Differentially methylated regions within lung cancer risk loci are enriched in deregulated enhancers

Autor: Marina Laplana, Matthias Bieg, Christian Faltus, Svitlana Melnik, Olga Bogatyrova, Zuguang Gu, Thomas Muley, Michael Meister, Hendrik Dienemann, Esther Herpel, Christopher I. Amos, Matthias Schlesner, Roland Eils, Christoph Plass, Angela Risch

Publikováno v: Epigenetics, Vol 17, Iss 2, Pp 117-132 (2022)

Genome-wide association studies (GWAS) have identified SNPs linked with lung cancer risk. Our aim was to discover the genes, non-coding RNAs, and regulatory elements within GWAS-identified risk regions that are deregulated in non-small cell lung carc

Externí odkaz: https://doaj.org/article/cb891c49a1b84bcea2c61c7b01623809

Supplementary Table 1 from Evolution of DNA Methylation Is Linked to Genetic Aberrations in Chronic Lymphocytic Leukemia

Autor: Christoph Plass, Thorsten Zenz, John C. Byrd, Stephan Stilgenbauer, Hartmut Döhner, Peter Lichter, Daniel Mertens, Thomas J. Kipps, Laura Rassenti, Christopher R. Schmidt, Olga Bogatyrova, David Brocks, Matthias Bieg, Manuela Zucknick, Jennifer Hüllein, Yassen Assenov, Lei Gu, Rainer Claus, Christopher C. Oakes

XLSX file 47K, Supplementary table 1: Clinical and biological features of all samples and timepoints used in the study including all genetic alterations found per sample

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::508ce1f0884cea31471d7bc1c4d3d9cc
https://doi.org/10.1158/2159-8290.22530033.v1

Brain penetration and efficacy of tepotinib in orthotopic patient-derived xenograft models of MET-driven non-small cell lung cancer brain metastases

Autor: Manja, Friese-Hamim, Anderson, Clark, Dominique, Perrin, Lindsey, Crowley, Christof, Reusch, Olga, Bogatyrova, Hong, Zhang, Timothy, Crandall, Jing, Lin, Jianguo, Ma, David, Bachner, Jürgen, Schmidt, Martin, Schaefer, Christopher, Stroh

Publikováno v: Lung Cancer. 163:77-86

Central nervous system-penetrant therapies with intracranial efficacy against non-small cell lung cancer (NSCLC) brain metastases are urgently needed. We report preclinical studies investigating brain penetration and intracranial activity of the MET

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6251c962bc1d7af754da95a0bf7ce932
https://doi.org/10.1016/j.lungcan.2021.11.020

Intratumor DNA Methylation Heterogeneity Reflects Clonal Evolution in Aggressive Prostate Cancer

Autor: David Brocks, Yassen Assenov, Sarah Minner, Olga Bogatyrova, Ronald Simon, Christina Koop, Christopher Oakes, Manuela Zucknick, Daniel Bernhard Lipka, Joachim Weischenfeldt, Lars Feuerbach, Richard Cowper-Sal·lari, Mathieu Lupien, Benedikt Brors, Jan Korbel, Thorsten Schlomm, Amos Tanay, Guido Sauter, Clarissa Gerhäuser, Christoph Plass

Publikováno v: Cell Reports, Vol 8, Iss 3, Pp 798-806 (2014)

Despite much evidence on epigenetic abnormalities in cancer, it is currently unclear to what extent epigenetic alterations can be associated with tumors’ clonal genetic origins. Here, we show that the prostate intratumor heterogeneity in DNA methyl

Externí odkaz: https://doaj.org/article/4743815c9977460b8aaaf8cc7d7de194

Differentially methylated regions within lung cancer risk loci are enriched in deregulated enhancers

Autor: Christopher I. Amos, Olga Bogatyrova, Michael Meister, Matthias Bieg, Christoph Plass, Roland Eils, Thomas Muley, Hendrik Dienemann, Esther Herpel, Zuguang Gu, Svitlana Melnik, Christian Faltus, Angela Risch, Matthias Schlesner, Marina Laplana

Publikováno v: Recercat. Dipósit de la Recerca de Catalunya
instname
Repositorio Abierto de la UdL
Universitad de Lleida
Recercat: Dipósit de la Recerca de Catalunya
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)

Genome-wide association studies (GWAS) have identified SNPs linked with lung cancer risk. Our aim was to discover the genes, non-coding RNAs, and regulatory elements within GWAS-identified risk regions that are deregulated in non-small cell lung carc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf086003946e8c451ec82b484fcdb18c
https://hdl.handle.net/10459.1/70710