Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Oleta T. Johnson"'
Autor:
Pengfei Xu, Joy C. Yang, Bo Chen, Shu Ning, Xiong Zhang, Leyi Wang, Christopher Nip, Yuqiu Shen, Oleta T. Johnson, Gabriela Grigorean, Brett Phinney, Liangren Liu, Qiang Wei, Eva Corey, Clifford G. Tepper, Hong-Wu Chen, Christopher P. Evans, Marc A. Dall’Era, Allen C. Gao, Jason E. Gestwicki, Chengfei Liu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract N-Myc is a key driver of neuroblastoma and neuroendocrine prostate cancer (NEPC). One potential way to circumvent the challenge of undruggable N-Myc is to target the protein homeostasis (proteostasis) system that maintains N-Myc levels. Here
Externí odkaz:
https://doaj.org/article/7245d627558b40309015d3fca64f4865
Autor:
Miyuu Tanaka, Ryoko Fujikawa, Takahiro Sekiguchi, Jason Hernandez, Oleta T. Johnson, Daisuke Tanaka, Kenta Kumafuji, Tadao Serikawa, Hieu Hoang Trung, Kosuke Hattori, Tomoji Mashimo, Mitsuru Kuwamura, Jason E. Gestwicki, Takashi Kuramoto
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
Neuroaxonal dystrophy (NAD) is a neurodegenerative disease characterized by spheroid (swollen axon) formation in the nervous system. In the present study, we focused on a newly established autosomal recessive mutant strain of F344-kk/kk rats with hin
Externí odkaz:
https://doaj.org/article/b5bf84a562e746e195914f25780aba1c
Autor:
Pengfei Xu, Joy C. Yang, Shu Ning, Bo Chen, Christopher Nip, Qiang Wei, Liangren Liu, Oleta T. Johnson, Allen C. Gao, Jason E. Gestwicki, Christopher P. Evans, Chengfei Liu
Publikováno v:
Pharmacological Research, Vol 189, Iss , Pp 106692- (2023)
Ubiquitin proteasome activity is suppressed in enzalutamide resistant prostate cancer cells, and the heat shock protein 70/STIP1 homology and U-box-containing protein 1 (HSP70/STUB1) machinery are involved in androgen receptor (AR) and AR variant pro
Externí odkaz:
https://doaj.org/article/0aa5beefd47948149ef46484906a60a3
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1063 (2022)
Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor mainly caused by mutations in the RET proto-oncogene. We previously demonstrated that depletion of the mitochondrial molecular chaperone, mortalin, can effectively suppress human MTC cells i
Externí odkaz:
https://doaj.org/article/440300398f0a479396452eae9b81b851
Autor:
Frank J Echtenkamp, Ryo Ishida, Genesis M Rivera-Marquez, Marisa Maisiak, Oleta T Johnson, Jonathan H Shrimp, Arnav Sinha, Stephen John Ralph, Ian Nisbet, Murali Krishna Cherukuri, Jason E Gestwicki, Leonard M Neckers
Publikováno v:
PNAS Nexus
PNAS nexus, vol 2, iss 4
PNAS nexus, vol 2, iss 4
The androgen receptor is a key regulator of prostate cancer and the principal target of current prostate cancer therapies collectively termed androgen deprivation therapies. Insensitivity to these drugs is a hallmark of progression to a terminal dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c14ec7cbf7dcddfe214f2794fc2679b
https://europepmc.org/articles/PMC10118397/
https://europepmc.org/articles/PMC10118397/
Autor:
Taiasean Wu, Joshua C. Yu, Arundhati Suresh, Zachary J. Gale-Day, Matthew G. Alteen, Amanda S. Woo, Zoe Millbern, Oleta T. Johnson, Emma C. Carroll, Carrie L. Partch, Denis Fourches, Nelson R. Vinueza, David J. Vocadlo, Jason E. Gestwicki
Publikováno v:
bioRxiv
Flexiblein vitromethods alter the course of biological discoveries. Differential Scanning Fluorimetry (DSF) is a particularly versatile technique which reports protein thermal unfolding via fluorogenic dye. However, applications of DSF are limited by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d03291079a6a373b1f6e6704c4faa17f
https://doi.org/10.1101/2023.01.23.525251
https://doi.org/10.1101/2023.01.23.525251
Publikováno v:
ChemBioChem. 20:40-45
Proteins containing intrinsic disorder often form secondary structure upon interaction with a binding partner. Modulating such structures presents an approach for manipulating the resultant functional outcomes. Translational repressor protein 4E-BP1
Autor:
Delaney Osborn, Taia S. Wu, Jennifer N. Rauch, Oleta T. Johnson, Leah N. Makley, Jason E. Gestwicki, Heather A. Carlson, Phani Ghanakota, Tomasz Cierpicki
Publikováno v:
Bioorg Med Chem
Destabilizing mutations in small heat shock proteins (sHsps) are linked to multiple diseases; however, sHsps are conformationally dynamic, lack enzymatic function and have no endogenous chemical ligands. These factors render sHsps as classically “u