Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Olesya A. Ulanovskaya"'
Supplementary Figure Legends from Linking Cancer Metabolism to DNA Repair and Accelerated Senescence
Autor:
Stephen J. Kron, Sergey A. Kozmin, Ralph R. Weichselbaum, Olesya A. Ulanovskaya, Edwardine Labay, Ding Wu, Noumaan A. Shamsi, Satoe Takahashi, Elena V. Efimova
Supplementary Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4048a53234bda4177dcc04fcb4e8ceb6
https://doi.org/10.1158/1541-7786.22511041.v1
https://doi.org/10.1158/1541-7786.22511041.v1
Autor:
Stephen J. Kron, Sergey A. Kozmin, Ralph R. Weichselbaum, Olesya A. Ulanovskaya, Edwardine Labay, Ding Wu, Noumaan A. Shamsi, Satoe Takahashi, Elena V. Efimova
Small molecules used in this study.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::197640ce1238954e924149f206e9d54a
https://doi.org/10.1158/1541-7786.22511038
https://doi.org/10.1158/1541-7786.22511038
Autor:
Stephen J. Kron, Sergey A. Kozmin, Ralph R. Weichselbaum, Olesya A. Ulanovskaya, Edwardine Labay, Ding Wu, Noumaan A. Shamsi, Satoe Takahashi, Elena V. Efimova
Histone demethylases mediate effects of alpha-KG.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0984c064a26537add9d06a9551db213
https://doi.org/10.1158/1541-7786.22511044.v1
https://doi.org/10.1158/1541-7786.22511044.v1
Autor:
Jan-Sebastian Grigoleit, Alex Reed, Haoxin Li, Sabrina Barbas, Olesya A. Ulanovskaya, Benjamin F. Cravatt, Hui Jing, Kim Masuda, Jason Germain, Cassandra L. Henry, Dylan M. Herbst
Publikováno v:
Proc Natl Acad Sci U S A
Human genetic studies have pointed to a prominent role for innate immunity and lipid pathways in immunological and neurodegenerative disorders. Our understanding of the composition and function of immunomodulatory lipid networks in innate immune cell
Autor:
Benjamin F. Cravatt, Jonathan J. Hulce, Daisuke Ogasawara, Taka-Aki Ichu, Alex Reed, Olesya A. Ulanovskaya, Hui Jing
Publikováno v:
Journal of Medicinal Chemistry. 62:1643-1656
ABHD12 is a membrane-bound hydrolytic enzyme that acts on the lyso-phosphatidylserine (lyso-PS) and lyso-phosphatidylinositol (lyso-PI) classes of immunomodulatory lipids. Human and mouse genetic studies point to a key role for the ABHD12-(lyso)-PS/P
Autor:
Jacqueline R. Benthuysen, Vincent F. Vartabedian, Alex Reed, Hugh Rosen, Benjamin F. Cravatt, Amanda J. Roberts, Daisuke Ogasawara, Olesya A. Ulanovskaya, Hui Jing, Taka-Aki Ichu, Jonathan J. Hulce, John R. Teijaro, Steven D. Brown
Publikováno v:
Nature chemical biology
ABHD12 metabolizes bioactive lysophospholipids, including lysophosphatidylserine (lyso-PS). Deleterious mutations in human ABHD12 cause the neurological disease PHARC, and ABHD12(−/−) mice display PHARC-like phenotypes, including hearing loss, al
Autor:
Daisuke Ogasawara, Bruno Conti, Jason Germain, Kim Masuda, Liron Bar-Peled, Olesya A. Ulanovskaya, Amanda J. Roberts, Jie Gao, Taka-Aki Ichu, Sabrina Barbas, Benjamin F. Cravatt, Carlos A. Aguirre, Alex Reed, Peter Tontonoz
Publikováno v:
Biochemistry
PHARC (polyneuropathy, hearing loss, cerebellar ataxia, retinitis pigmentosa, and cataract) is a human neurological disorder caused by deleterious mutations in the ABHD12 gene, which encodes an integral membrane lyso-phosphatidylserine (lyso-PS) lipa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce2c2d2fe86799d2b9d7c9bfcf98d189
https://europepmc.org/articles/PMC7394188/
https://europepmc.org/articles/PMC7394188/
Autor:
Benjamin D. Horning, Olesya A. Ulanovskaya, Radu M. Suciu, Benjamin F. Cravatt, Hsinyu Lee, Ekaterina V. Vinogradova
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:2682-2687
Nicotinamide N-methyltransferase (NNMT) catalyzes the N-methylation of nicotinamide using S-adenosyl-L-methionine (SAM) as a methyl donor and, through doing so, can modulate cellular methylation potential to impact diverse epigenetic processes. NNMT
Autor:
Elena V. Efimova, Edwardine Labay, Sergey A. Kozmin, Ding Wu, Olesya A. Ulanovskaya, Stephen J. Kron, Noumaan A. Shamsi, Ralph R. Weichselbaum, Satoe Takahashi
Publikováno v:
Molecular Cancer Research. 14:173-184
Conventional wisdom ascribes metabolic reprogramming in cancer to meeting increased demands for intermediates to support rapid proliferation. Prior models have proposed benefits toward cell survival, immortality, and stress resistance, although the r
Autor:
Alan L. Hutchison, Olesya A. Ulanovskaya, Chuan He, Fei Sun, Tianhong Zhou, Zhike Lu, Min Wu, Benjamin F. Cravatt, Quanjiang Ji, Haihua Liang, Xin Deng, Lefu Lan
Publikováno v:
Journal of Bacteriology. 196:2499-2513
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from human pathogens Staphylococcus aureus and Pseudomonas aeruginosa can be readily inhibited by reactive oxygen species (ROS)-mediated direct oxidation of their catalytic active cysteines. Because of