Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Olesya A. Kharenko"'
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/a1923120593843f69e7646d8d34fd8cf
Autor:
Léa Mélin, Emily Gesner, Sarah Attwell, Olesya A. Kharenko, Edward H. van der Horst, Henrik C. Hansen, Alexandre Gagnon
Publikováno v:
ACS Omega, Vol 6, Iss 33, Pp 21327-21338 (2021)
Externí odkaz:
https://doaj.org/article/2ac6ac4ea775409387e171e7e5b01be8
Autor:
Laura M. Tsujikawa, Olesya A. Kharenko, Stephanie C. Stotz, Brooke D. Rakai, Christopher D. Sarsons, Dean Gilham, Sylwia Wasiak, Li Fu, Michael Sweeney, Jan O. Johansson, Norman C.W. Wong, Ewelina Kulikowski
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 152, Iss , Pp 113230- (2022)
Background: Bromodomain and extraterminal proteins (BETs) are more than just epigenetic regulators of transcription. Here we highlight a new role for the BET protein BRD4 in the maintenance of higher order chromatin structure at Topologically Associa
Externí odkaz:
https://doaj.org/article/8f4df9e6c3304f019c787cc9d257dbda
Publikováno v:
Cancer Gene Therapy. 29:859-869
CDK4/6 inhibitors significantly prolong progression-free survival in patients with advanced hormone receptor-positive (HR+) HER2-negative breast cancer. Despite recent successes, patients acquire resistance, necessitating the development of additiona
Autor:
Emily M. Gesner, Sarah Attwell, Henrik C. Hansen, Alexandre Gagnon, Olesya A. Kharenko, Edward H. van der Horst, Léa Mélin
Publikováno v:
ACS Omega, Vol 6, Iss 33, Pp 21327-21338 (2021)
ACS Omega
ACS Omega
PB1 is a bromodomain-containing protein hypothesized to act as the nucleosome-recognition subunit of the PBAF complex. Although PB1 is a key component of the PBAF chromatin remodeling complex, its exact role has not been elucidated due to the lack of
Publikováno v:
Cancer gene therapy. 29(6)
CDK4/6 inhibitors significantly prolong progression-free survival in patients with advanced hormone receptor-positive (HR+) HER2-negative breast cancer. Despite recent successes, patients acquire resistance, necessitating the development of additiona
Publikováno v:
Bioorganicmedicinal chemistry letters. 47
BPTF (bromodomain and PHD finger containing transcription factor) is a multidomain protein that plays essential roles in transcriptional regulation, T-cell homeostasis and stem cell pluripotency. As part of the chromatin remodeling complex hNURF (nuc
Autor:
Eric Campeau, Sanjay Lakhotia, Laura Tsujikawa, Sarah Attwell, Olesya A. Kharenko, Reena G. Patel, Cyrus Calosing, Ravi Jahagirdar, Henrik C. Hansen
Publikováno v:
Cancer Research. 78:P3-06
More than 200,000 women are diagnosed with breast cancer every year in the United States. About 80% of these cases are estrogen receptor positive (ER+), which is characterized by the up-regulation of ER signaling and downstream activation of cyclin-d
Publikováno v:
Cancer Research. 81:1129-1129
Estrogen receptor positive breast cancer (ER+) remains a very prevalent disease with a high mortality rate despite recent successes with new therapies such as CDK4/6, PARP, and PI3K inhibitors. These therapies have shown to significantly prolong prog
Autor:
Henrik C. Hansen, Olesya A. Kharenko
Publikováno v:
Drug Discovery Today: Technologies. 24:19-24
Inhibition of bromo and extra-terminal (BET) bromodomains, including BRD4, has emerged as a new exciting epigenetic target for oncology, in particular. Recently, novel alternatives to the traditional use of reversible small molecules have emerged, in