Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Olesoxime"'
Akademický článek
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Autor:
Maryam Kaviani, Somayeh Keshtkar, Negar Azarpira, Mahdokht Hossein Aghdaei, Bita Geramizadeh, Mohammad Hossein Karimi, Alireza Shamsaeefar, Nasrin Motazedian, Saman Nikeghbalian, Ismail H. Al-Abdullah, Mohammad Hossein Ghahremani
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 112, Iss , Pp - (2019)
Background and purpose: Islet transplantation is considered as a promising approach in the treatment of diabetes type 1. In this regard, optimal culture of the pancreatic islets is promising in the success of transplantation. In the present study, th
Externí odkaz:
https://doaj.org/article/848ee3cf14ad43dca7d99e926ff6ab3c
Objective: During cardioplegia, which is often used in cardiac surgery, the heart is subjected to global ischemia/reperfusion injury, which can result in a post-operative impairment of cardiac function. Mitochondria permeability transition pores (MPT
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A83755
https://ul.qucosa.de/api/qucosa%3A83755/attachment/ATT-0/
https://ul.qucosa.de/api/qucosa%3A83755/attachment/ATT-0/
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
Objective: During cardioplegia, which is often used in cardiac surgery, the heart is subjected to global ischemia/reperfusion injury, which can result in a post-operative impairment of cardiac function. Mitochondria permeability transition pores (MPT
Externí odkaz:
https://doaj.org/article/fb260ad9c80f4db7908233d2396c34a9
Autor:
Eugenio, Mercuri, Giovanni, Baranello, Odile, Boespflug-Tanguy, Liesbeth, De Waele, Nathalie, Goemans, Janbernd, Kirschner, Riccardo, Masson, Elena S, Mazzone, Astrid, Pechmann, Maria Carmela, Pera, Carole, Vuillerot, Silvia, Bader-Weder, Marianne, Gerber, Ksenija, Gorni, Janine, Hoffart, Heidemarie, Kletzl, Carmen, Martin, Tammy, McIver, Renata S, Scalco, Wai Yin, Yeung, Laurent, Servais
Publikováno v:
European journal of neurologyREFERENCES.
BACKGROUND AND PURPOSE: Spinal muscular atrophy (SMA) is caused by reduced levels of survival of motor neuron (SMN) protein due to deletions and/or mutations in the SMN1 gene. Risdiplam is an orally administered molecule that modifies SMN2 pre-mRNA s
Autor:
Eugenio Mercuri, M. El-Khairi, Ksenija Gorni, Carol Reid, Giacomo P. Comi, W. Ludo van der Pol, Enrico Bertini, Carole Vuillerot, Alexander Burdeska, Francesco Muntoni, Mariacristina Scoto, Sabine Fuerst-Recktenwald, Anna Lusakowska, Jane Ives, Janbernd Kirschner, Paulo Fontoura
Publikováno v:
Neuromuscular Disorders
Neuromuscular Disorders, 2020, 30 (12), pp.959-969. ⟨10.1016/j.nmd.2020.10.008⟩
Neuromuscular Disorders, 2020, 30 (12), pp.959-969. ⟨10.1016/j.nmd.2020.10.008⟩
International audience; In a previous Phase 2 study, olesoxime had a favorable safety profile. Although the primary endpoint was not met, analyses suggested that olesoxime might help in the maintenance of motor function in patients with Types 2/3 SMA
Autor:
María Queralt-Martín, Mark R. Cookson, Alexandra Beilina, Amandine Rovini, William M. Rosencrans, Philip A. Gurnev, Sergey M. Bezrukov, Tatiana K. Rostovtseva
Publikováno v:
Cellular and Molecular Life Sciences. 77:3611-3626
An intrinsically disordered neuronal protein α-synuclein (αSyn) is known to cause mitochondrial dysfunction, contributing to loss of dopaminergic neurons in Parkinson's disease. Through yet poorly defined mechanisms, αSyn crosses mitochondrial out
Publikováno v:
Biochemical Pharmacology. 168:305-318
Over the last years, the experimental compound olesoxime, a mitochondria-targeting cholesterol derivative, has emerged as a promising drug candidate for neurodegenerative diseases. Numerous preclinical studies have successfully proved olesoxime’s n
Publikováno v:
Pharmaceuticals, Vol 3, Iss 2, Pp 345-368 (2010)
Olesoxime (TRO19622) is a novel mitochondrial-targeted neuroprotective compound undergoing a pivotal clinical efficacy study in Amyotrophic Lateral Sclerosis (ALS) and also in development for Spinal Muscular Atrophy (SMA). It belongs to a new family
Externí odkaz:
https://doaj.org/article/728cf9d24bc147f3bce7923066258f01
Publikováno v:
Expert opinion on investigational drugs. 30(8)
Introduction: Multiple sclerosis (MS) is the most common inflammatory disease of the central nervous system (CNS). Demyelination, the main pathology in MS, contributes to clinical symptoms and long...