Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Olena Kuksenko"'
Autor:
James M. McFarland, Brenton R. Paolella, Allison Warren, Kathryn Geiger-Schuller, Tsukasa Shibue, Michael Rothberg, Olena Kuksenko, William N. Colgan, Andrew Jones, Emily Chambers, Danielle Dionne, Samantha Bender, Brian M. Wolpin, Mahmoud Ghandi, Itay Tirosh, Orit Rozenblatt-Rosen, Jennifer A. Roth, Todd R. Golub, Aviv Regev, Andrew J. Aguirre, Francisca Vazquez, Aviad Tsherniak
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Large-scale screens of chemical and genetic vulnerabilities in cancer are typically limited to simple readouts of cell viability. Here, the authors develop a method for profiling post-perturbation transcriptional responses across large pools of cance
Externí odkaz:
https://doaj.org/article/464481c452404d5080918310ac391162
Autor:
Kathryn Geiger-Schuller, Basak Eraslan, Olena Kuksenko, Kushal K. Dey, Karthik A. Jagadeesh, Pratiksha I. Thakore, Ozge Karayel, Andrea R. Yung, Anugraha Rajagopalan, Ana M Meireles, Karren Dai Yang, Liat Amir-Zilberstein, Toni Delorey, Devan Phillips, Raktima Raychowdhury, Christine Moussion, Alkes L. Price, Nir Hacohen, John G. Doench, Caroline Uhler, Orit Rozenblatt-Rosen, Aviv Regev
Publikováno v:
bioRxiv
E3 ligases regulate key processes, but many of their roles remain unknown. Using Perturb-seq, we interrogated the function of 1,130 E3 ligases, partners and substrates in the inflammatory response in primary dendritic cells (DCs). Dozens impacted the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3d8f305a048b8acb0f805d0af1ceb7e
https://europepmc.org/articles/PMC9900845/
https://europepmc.org/articles/PMC9900845/
Autor:
Gökcen Eraslan, Eugene Drokhlyansky, Shankara Anand, Evgenij Fiskin, Ayshwarya Subramanian, Michal Slyper, Jiali Wang, Nicholas Van Wittenberghe, John M. Rouhana, Julia Waldman, Orr Ashenberg, Monkol Lek, Danielle Dionne, Thet Su Win, Michael S. Cuoco, Olena Kuksenko, Alexander M. Tsankov, Philip A. Branton, Jamie L. Marshall, Anna Greka, Gad Getz, Ayellet V. Segrè, François Aguet, Orit Rozenblatt-Rosen, Kristin G. Ardlie, Aviv Regev
Publikováno v:
Science. 376
Understanding gene function and regulation in homeostasis and disease requires knowledge of the cellular and tissue contexts in which genes are expressed. Here, we applied four single-nucleus RNA sequencing methods to eight diverse, archived, frozen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ac2ac5b95fe89c000768ce55acd8869
https://doi.org/10.1126/science.abl4290
https://doi.org/10.1126/science.abl4290
Autor:
Julia Joung, Sai Ma, Tristan Tay, Kathryn R. Geiger-Schuller, Paul C. Kirchgatterer, Vanessa K. Verdine, Baolin Guo, Mario A. Arias-Garcia, William E. Allen, Ankita Singh, Olena Kuksenko, Omar O. Abudayyeh, Jonathan S. Gootenberg, Zhanyan Fu, Rhiannon K. Macrae, Jason D. Buenrostro, Aviv Regev, Feng Zhang
Publikováno v:
Cell. 186(1)
Transcription factors (TFs) regulate gene programs, thereby controlling diverse cellular processes and cell states. To comprehensively understand TFs and the programs they control, we created a barcoded library of all annotated human TF splice isofor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::837a714484416964b4e991d1d7162945
https://pubmed.ncbi.nlm.nih.gov/36608654
https://pubmed.ncbi.nlm.nih.gov/36608654
Autor:
Olena Kuksenko, John M. Rouhana, Anna Greka, Aviv Regev, Orit Rozenblatt-Rosen, François Aguet, Evgenij Fiskin, Nicholas Van Wittenberghe, Philip A. Branton, Julia Waldman, Danielle Dionne, Eugene Drokhlyansky, Ayellet V. Segrè, Michael S. Cuoco, Ayshwarya Subramanian, Jiali Wang, Kristin G. Ardlie, Gökcen Eraslan, Michal Slyper, Thet Su Win, Shankara Anand, Gad Getz, Orr Ashenberg, Jamie L. Marshall
Understanding the function of genes and their regulation in tissue homeostasis and disease requires knowing the cellular context in which genes are expressed in tissues across the body. Single cell genomics allows the generation of detailed cellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2601fe775f841543159b6b091d4fa8cf
https://doi.org/10.1101/2021.07.19.452954
https://doi.org/10.1101/2021.07.19.452954
Autor:
William Colgan, Itay Tirosh, Emily Chambers, Andrew Jones, James M. McFarland, Jennifer Roth, Aviad Tsherniak, Michael V. Rothberg, Samantha Bender, Todd R. Golub, Kathryn Geiger-Schuller, Francisca Vazquez, Mahmoud Ghandi, Andrew J. Aguirre, Allison Warren, Olena Kuksenko, Aviv Regev, Orit Rozenblatt-Rosen, Brenton R. Paolella, Danielle Dionne, Tsukasa Shibue, Brian M. Wolpin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Assays to study cancer cell responses to pharmacologic or genetic perturbations are typically restricted to using simple phenotypic readouts such as proliferation rate. Information-rich assays, such as gene-expression profiling, have generally not pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fec36ee579d1fcfd5173d20cdf8331e0
https://doi.org/10.1038/s41467-020-17440-w
https://doi.org/10.1038/s41467-020-17440-w
Autor:
Francisca Vazquez, Kathryn Geiger-Schuller, Danielle Dionne, Tsukasa Shibue, Samantha Bender, Todd R. Golub, Aviad Tsherniak, Andrew Jones, Orit Rozenblatt-Rosen, Andrew J. Aguirre, Mahmoud Ghandi, Brenton R. Paolella, James M. McFarland, Aviv Regev, Brian M. Wolpin, Allison Warren, Jennifer Roth, Emily Chambers, Michael V. Rothberg, Itay Tirosh, Olena Kuksenko
Assays to study cancer cell responses to pharmacologic or genetic perturbations are typically restricted to using simple phenotypic readouts such as proliferation rate or the expression of a marker gene. Information-rich assays, such as gene-expressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bfc2ab347c32bbb295486f8878ef2cf
Genetic interactions, defined as the non-additive phenotypic impact of combinations of genes, are a hallmark of the mapping from genotype to phenotype. However, genetic interactions remain challenging to systematically test given the massive number o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdd6299da636c7df23be7d95957e98d2
Autor:
Olena Kuksenko, Nicholas Van Wittenberghe, Gökcen Eraslan, Aviv Regev, Eugene Drokhlyansky, Michael S. Cuoco, Gabriel K. Griffin, Christopher Smillie, Genevieve M. Boland, Maria Ericsson, Orit Rozenblatt-Rosen, Tatyana Sharova, Max N. Goder-Reiser, Danielle Dionne, Andrew J. Aguirre, Daniel B. Graham, Ramnik J. Xavier
Publikováno v:
Cell
The enteric nervous system (ENS) coordinates diverse functions in the intestine but has eluded comprehensive molecular characterization because of the rarity and diversity of cells. Here we develop two methods to profile the ENS of adult mice and hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::335d2e0f07fac538c4f0db8201e44767
https://pubmed.ncbi.nlm.nih.gov/33087897
https://pubmed.ncbi.nlm.nih.gov/33087897