Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Olena I. Vovk"'
Autor:
Andreas Deutsch, C. Noreen Hinrichs, Achim Temme, Alvaro Köhn-Luque, M. Ingargiola, Leoni A. Kunz-Schughart, Olena I. Vovk, Steffen Löck, Theresa Käubler, Oleh V. Stasyk
Publikováno v:
Molecular Cancer Therapeutics. 17:393-406
Tumor cells—even if nonauxotrophic—are often highly sensitive to arginine deficiency. We hypothesized that arginine deprivation therapy (ADT) if combined with irradiation could be a new treatment strategy for glioblastoma (GBM) patients because s
Autor:
Galyna Shuvayeva, Mary T. Fletcher, Olena I. Vovk, Yaroslav Bobak, Leoni A. Kunz-Schughart, Oleh V. Stasyk
Publikováno v:
Cell biology internationalReferences. 45(3)
Arginine-deprivation therapy is a rapidly developing metabolic anticancer approach. To overcome the resistance of some cancer cells to this monotherapy, rationally designed combination modalities are needed. In this report, we evaluated for the first
Autor:
O. Yu. Senchuk, O. I. Chen, N. I. Igumentseva, Oleh V. Stasyk, Olena I. Vovk, M. L. Barska, Natalia Sybirna
Publikováno v:
Ukrainian Biochemical Journal, Vol 88, Iss 2, Pp 45-55 (2016)
It was previously demonstrated in in vitro experiments that canavanine (Cav), a natural toxic arginine analogue of plant origin, is a promising candidate for augmenting the antineoplastic effects of arginine starvation. We demonstrated herein that re
Autor:
Bohdanna Kavalets, Olena I. Vovk, Lilianna Lyniv, Oleh Chen, Oleh V. Stasyk, M. L. Barska, Natalia Sybirna
Publikováno v:
Current Issues in Pharmacy and Medical Sciences. 26:385-389
Recombinant human arginase (rhARG)-based therapy to restrict arginine availability for malignant cells is a promising strategy to treat some cancers, including those of hematological origin. In the present study, we evaluated the action of combined r