STK11 pathway in vitro validation

Autor: Ioannis Siavelis, Elsa Arbajian, Hassan Foroughi Asl, Mohammad Pirmoradian, David Tamborero, Husen M. Umer, Henrik J. Johansson, Vilde Drageset Haakensen, Olena Berkovska, Georgios Mermelekas, Johan Staaf, Janne Lehtiö, Odd Terje Brustugun, Anna Karlsson, Krishna Pinganksha Purohit, Richard Cunningham, Yanbo Pan, Taner Arslan, Rui M. Branca, Lukas M. Orre, Carsten Gram Hanson, Fabio Socciarelli, Åslaug Helland, Hans Brunnström, Sofi Isaksson, Mattias Aine, Marija Kotevska, Mats Jonsson

The associated publication reports proteogenomic analysis of non-small cell lung cancer (NSCLC), where we identified molecular subtypes with distinct immune evasion mechanisms and therapeutic targets, and validated our classification method in separa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a7ff17a8e81edef7889b7dde9b70adc
https://doi.org/10.21203/rs.3.pex-1561/v1

Proteogenomics of non-small cell lung cancer reveals molecular subtypes associated with specific therapeutic targets and immune evasion mechanisms

Autor: Henrik J. Johansson, Marija Kotevska, Rui M. M. Branca, Sofi Isaksson, Krishna Pinganksha Purohit, Carsten G. Hansen, Mohammad Pirmoradian, Georgios Mermelekas, Odd Terje Brustugun, Olena Berkovska, David Tamborero, Richard Cunningham, Husen M. Umer, Janne Lehtiö, Yanbo Pan, Maria Planck, Åslaug Helland, Lukas M. Orre, Fabio Socciarelli, Taner Arslan, Anna Karlsson, Mats Jönsson, Elsa Arbajian, Hassan Foroughi Asl, Vilde Drageset Haakensen, Ioannis Siavelis, Mattias Aine, Johan Staaf, Hans Brunnström

Publikováno v: Nature Cancer
Lehtiö, J, Arslan, T, Siavelis, I, Pan, Y, Socciarelli, F, Berkovska, O, Umer, H M, Mermelekas, G, Pirmoradian, M, Jönsson, M, Brunnström, H, Brustugun, O T, Purohit, K P, Cunningham, R, Foroughi Asl, H, Isaksson, S, Arbajian, E, Aine, M, Karlsson, A, Kotevska, M, Gram Hansen, C, Drageset Haakensen, V, Helland, Å, Tamborero, D, Johansson, H J, Branca, R M, Planck, M, Staaf, J & Orre, L M 2021, ' Proteogenomics of non-small cell lung cancer reveals molecular subtypes associated with specific therapeutic targets and immune-evasion mechanisms ', nature cancer, vol. 2, no. 11, pp. 1224-1242 . https://doi.org/10.1038/s43018-021-00259-9

Despite major advancements in lung cancer treatment, long-term survival is still rare and a deeper understanding of molecular phenotypes would allow the identification of specific cancer dependencies and immune-evasion mechanisms. Here we performed i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8af0d696185c5ea5334a160bc13b493