Výsledky vyhledávání - "Oleksii M. Antypenko"

Akademický článek

Potential of N-aryl(benzyl,heteryl)-2-(tetrazolo[1,5-c]quinazolin-5-ylthio)acetamides as anticancer and antimicrobial agents

Autor: Oleksii M. Antypenko, Lyudmyla M. Antypenko, Sergiy I. Kovalenko, Andrey M. Katsev, Olena M. Achkasova

Publikováno v: Arabian Journal of Chemistry, Vol 9, Iss 6, Pp 792-805 (2016)

The death rate from cancer and infectious diseases is still very high, therefore research in this area is extremely important and promising as in medical, so in economic point of view. Thus, potassium salt of tetrazolo[1,5-c]quinazolin-5-thion was mo

Externí odkaz: https://doaj.org/article/4dba385302d148c18f0a04a0dcdaba1a

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Тhio-containing pteridines: Synthesis, modification, and biological activity

Autor: Maxim S. Kazunin, N. V. Groma, Inna S. Nosulenko, Anna O. Kinichenko, Oleksii M. Antypenko, Volodymyr M. Shvets, Oleksii Y. Voskoboinik, Serhii I. Kovalenko

Publikováno v: Archiv der PharmazieREFERENCES. 355(12)

The present article is devoted to searching for biologically active agents among novel thio-containing pteridines. Synthetic protocols based on the condensation of 5,6-diamino-2-thioxo-2,3-dihydropyrimidin-4(1H)-ones with dicarbonyl compounds were el

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25923e0745e83b13f1f33c9e3d76426b
https://pubmed.ncbi.nlm.nih.gov/36166689

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Directed Search of Anti-inflammatory Agents Among (3H-Quinazoline-4-ylidene)hydrazides of N-protected Amino acids and their Heterocyclization Products

Autor: Oleksii M. Antypenko, Sergii Ivanovich Kovalenko, I. S. Nosulenko, G. G. Berest, Yulya Martynenko

Publikováno v: Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Background: (Quinazoline-4-ylidene)hydrazides are valued intermediates in modern organic chemistry, as they are commonly used for the synthesis of substituted [1,2,4]triazolo[1,5-c]quinazolines. Objective: Unknown N-acyl-2-([1,2,4]triazolo[1,5-c]quin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e633eaaf9935f83599f85687ff7d7591
http://europepmc.org/articles/PMC7460736

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Directed Search of Biologically Active Compounds among Hydrogenated Isoindolylalkyl(alkylaryl-,aryl-)carboxylic Acids with Quinazoline Fragment that Modify the Carbohydrate Metabolism: Design, Synthesis and Modification

Autor: Oleksandr Anatolievich Brazhko, Sergii Ivanovich Kovalenko, Oleksii M. Antypenko, Irina Borisivna Labenska, Yulya Martynenko

Publikováno v: Acta Chimica Slovenica, Vol 66, Iss 1, Pp 145-154 (2019)

An effective synthesis of (3 H -quinazoline-4-ylidene)hydrazides of N -carboxyalkyl-(arylalkyl-,aryl-)isoindoline-1,3-diones, using activated N -protected aminoacids and 4-hydrazinoquinazoline was proposed in the framework methodology of directed sea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad482bccdec7ff436060d150c9a98353
https://doi.org/10.17344/acsi.2018.4731

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Synthesis and structure of pyrido[1,2-a]quinazoline condensed derivatives

Autor: Sergiy I. Kovalenkoa, Olexii Yu. Voskoboinik, Maksym S. Kazunin, Svetlana V. Shishkina, Oleksii M. Antypenko, Dmytro V. Kravtsov, V. V. Stavytskyi

Present manuscript describes the synthesis and molecular structure features of novel condensed pyrido[1,2-a]quinazolines. The above-mentioned compounds were synthesized via condensation of 2-[azolyl-(аzinyl-)]anilines with 5-oxohexanoic acid. The ta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::423a2a990ab27553ebd49be3fcf2d852

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Substituted 3-R-2,8-Dioxo-7,8-dihydro-2H-pyrrolo[1,2-a][1,2,4] triazino [2,3-c]quinazoline-5a(6H)carboxylic Acids and their Salts - a Promising Class of Anti-inflammatory Agents

Autor: I. S. Nosulenko, Oleksii Voskoboinik, Oleksii M. Antypenko, Galyna G. Berest, Sergiy Kovalenko, V. V. Stavytskyi

Publikováno v: Anti-inflammatoryanti-allergy agents in medicinal chemistry. 20(1)

Background: Computer-aided drug design is among the most effective methods of medicinal chemistry. The above mentioned approach is used for the purposeful search of antiinflammatory agents among quinazoline condensed derivatives. Objective: The study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::296b5a31b2cf99657cfc4cce57ca6a15
https://pubmed.ncbi.nlm.nih.gov/32368980

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Design, Synthesis and Anti-inflammatory Activity of Derivatives 10-R-3-Aryl-6,7-dihydro-2H-[1,2,4] triazino[2,3-c]quinazolin-2-ones of Spiro-fused Cyclic Frameworks

Autor: Oleksii M. Antypenko, Galyna G. Berest, Оleksii Yu. Voskoboynik, Olexandr Karpenko, I. S. Nosulenko, Oleksandra S. Kolomoets, Vitaliy A. Palchikov, Sergiy I. Kovalenko

Publikováno v: Acta Chimica Slovenica, Vol 64, Iss 4, Pp 902-910 (2017)

Present work is devoted to the purposeful search of novel promising anti-inflammatory agents among the insufficiently known 3'-R-10'-R 1 -spiro[hetaryl-3(4),6'-[1,2,4]triazino[2,3- c ]quinazolin]-2'(7' H )-ones. The virtual combinatorial library of p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ea69630b05e259b5e04040cd8284cb9
https://doi.org/10.17344/acsi.2017.3575

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