Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Oleksandra Onopchenko"'
Autor:
Alexey Lukin, Anna Bakholdina, Mikhail Chudinov, Oleksandra Onopchenko, Elena Zhuravel, Sergey Zozulya, Maxim Gureev, Mikhail Krasavin
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1650-1657 (2021)
A set of 1,3,4-thiadiazole-2-carboxamides bearing a substituted biphenyl in the amide portion was synthesised and tested for agonistic activity towards free fatty acid receptor 1 (FFA1). The observed activity trends were impossible to rationalised ba
Externí odkaz:
https://doaj.org/article/9d3f63a014b74b7099392ec6f9080af1
Autor:
Elena Zhuravel, Anna Bakholdina, Sergey Zozulya, Oleksandra Onopchenko, Alexey Lukin, Mikhail V. Chudinov, Maxim Gureev, Mikhail Krasavin
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1650-1657 (2021)
Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
A set of 1,3,4-thiadiazole-2-carboxamides bearing a substituted biphenyl in the amide portion was synthesised and tested for agonistic activity towards free fatty acid receptor 1 (FFA1). The observed activity trends were impossible to rationalised ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55de74ce0fe2ae1d878f08a6596e2933
https://doaj.org/article/9d3f63a014b74b7099392ec6f9080af1
https://doaj.org/article/9d3f63a014b74b7099392ec6f9080af1
Autor:
Illia O. Feskov, Vasyl S. Naumchyk, Ivan S. Kondratov, Oleksandra Onopchenko, Oleksandr O. Grygorenko, Yu. O. Kuchkovska
Publikováno v:
Журнал органічної та фармацевтичної хімії, Vol 18, Iss 4(72), Pp 14-22 (2020)
Aim. To synthesize cis- and trans-isomers of 3-(4-hydroxyphenyl)cyclobutanecarboxylic acid and evaluate the biological activity of their derivatives against GPR-40. Results and discussion. Cis- and trans-isomers of 3-(4-hydroxyphenyl)cyclobutanecarbo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c0e0530bf87977325f8788431e8382e
http://ophcj.nuph.edu.ua/article/view/ophcj.20.210383
http://ophcj.nuph.edu.ua/article/view/ophcj.20.210383
Autor:
Alexander Safrygin, Elena Zhuravel, Alexey Lukin, Mikhail Krasavin, Anna Bakholdina, Maxim Gureev, Nikolay Zhurilo, Sergey Zozulya, Oleksandra Onopchenko
Publikováno v:
Archiv der PharmazieREFERENCES. 354(4)
Three types of heterocyclic moieties-piperidines fused to a heteroaromatic moiety-were explored as potential periphery motifs for the pharmacophoric core of fasiglifam (TAK-875), with fasiglifam being the most advanced agonist of free fatty acid rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14101c003a5ef5eaa4b79fdbadb38f34
https://pubmed.ncbi.nlm.nih.gov/33270252
https://pubmed.ncbi.nlm.nih.gov/33270252
Autor:
Nariman F. Salakhutdinov, Sergey Zozulya, Oleksandra Onopchenko, Iryna Pishel, Olga A. Luzina, Maxim Gureev, Mikhail Krasavin, Sergey Kuranov
Publikováno v:
Bioorganic chemistry. 99
Six derivatives of 3-phenylpropionic acid bearing various natural and natural-like, spatially defined peripheral motifs have been synthesized and evaluated in vitro for free fatty acid receptor 1 (FFA1) activation. Two frontrunner compounds (bearing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81fc48dfc78ce99545a708dd9e308b54
https://pubmed.ncbi.nlm.nih.gov/32289588
https://pubmed.ncbi.nlm.nih.gov/32289588
Autor:
Andrii Malashchuk, Alexey V. Dobrydnev, Oleksandra Onopchenko, M. O. Platonov, Vasyl V. Hurmach, Sergey Zozulya, Ivan S. Kondratov, Oleksandr O. Grygorenko, Anton V. Chernykh, Constantin G. Daniliuc, Yuriy S. Moroz
Publikováno v:
J Mol Struct
With the aim of circumventing the adverse cis/trans-isomerization of combretastatin A4 (CA4), a naturally occurring tumor-vascular disrupting agent, we designed novel CA4 analogs bearing 1,3-disubstituted cyclobutane moiety instead of the cis-stilben
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e06bfded83fc21b25010cb29bd37ab35
https://doi.org/10.1016/j.molstruc.2020.128025
https://doi.org/10.1016/j.molstruc.2020.128025