Induction of IL-10-producing type 2 innate lymphoid cells by allergen immunotherapy is associated with clinical response

Autor: Mongkol Lao-araya, Stephen R. Durham, Oliver Hunewald, Anke-Hilse Maitland-van der Zee, Balthasar A. Heesters, Janice A. Layhadi, Gemma Vilà-Nadal, Korneliusz Golebski, Esther H. Steveling-Klein, Mohamed H. Shamji, Rachael C.Y. Li, Suzanne M. Bal, Wytske Fokkens, Cornelis M. van Drunen, Feng He, Umit Murat Sahiner, Susanne J. H. Vijverberg, Markus Ollert, Oleksandra Fedina, Madison M. Lenormand, Hergen Spits, Guillem Montamat

Publikováno v: Immunity, 54(2), 291-307.e7. Cell Press
Immunity, 54(2), 291. Cell Press
307.e7
Golebski, K, Layhadi, J A, Sahiner, U, Steveling-Klein, E H, Lenormand, M M, Li, R C Y, Bal, S M, Heesters, B A, Vilà-Nadal, G, Hunewald, O, Montamat, G, He, F Q, Ollert, M, Fedina, O, Lao-Araya, M, Vijverberg, S J H, Maitland-van der Zee, A H, van Drunen, C M, Fokkens, W J, Durham, S R, Spits, H & Shamji, M H 2021, ' Induction of IL-10-producing type 2 innate lymphoid cells by allergen immunotherapy is associated with clinical response ', Immunity, vol. 54, no. 2, pp. 291-307.e7 . https://doi.org/10.1016/j.immuni.2020.12.013

The role of innate immune cells in allergen immunotherapy that confers immune tolerance to the sensitizing allergen is unclear. Here, we report a role of interleukin-10-producing type 2 innate lymphoid cells (IL-10+ ILC2s) in modulating grass-pollen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::622c6c31bcc0f5cbd5b2bdf9848d4676
https://pure.amc.nl/en/publications/induction-of-il10producing-type-2-innate-lymphoid-cells-by-allergen-immunotherapy-is-associated-with-clinical-response(229380d1-a168-41ca-a2cf-67cf7a6c8968).html

Immunotherapy for Upper Airway Disease Generates IL-10-Producing KLRG1 + ILC2s that are Associated with Clinical Benefit

Autor: Stephen R. Durham, Esther H. Steveling-Klein, Rachael C. Y. Li, Janice Layhadi, Suzanne M. Bal, Wytske Fokkens, Mohamed H. Shamji, Umit Murat Sahiner, Anke-Hilse Maitland-van der Zee, Oleksandra Fedina, Susanne J. H. Vijverberg, Madison M. Lenormand, Gemma Vilà-Nadal, Cornelis M. van Drunen, Balthasar A. Heesters, Korneliusz Golebski, Hergen Spits, Mongkol Lao-Araya

Publikováno v: SSRN Electronic Journal.

SummaryIn this study, we addressed the role of IL-10-producing ILCs in controlling grass pollen allergy. IL-10+ ILCs are comprised in KLRG1+ILC2-lineage cells and absent on CRTH2+ ILC2 which lack KLRG1. We observed that ILC2s in healthy subjects and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aa42d265157cc4dc9398ba0e76263772
https://doi.org/10.2139/ssrn.3611048

Novel machine learning-led discovery of adjuvant drug candidate for allergen immunotherapy using synthetic toll-like receptor 2/6 agonist

Autor: Janice Layhadi, Madison Lenormand, Max Kirtland, Gemma Vilà-Nadal, Oleksandra Fedina, Stephen Durham, Daphne Tsitoura, Mohamed Shamji, Lily Wu

Publikováno v: Journal of Allergy and Clinical Immunology. 149:AB71

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e7f87d9e4c6f9976c1598d7affcf744f
https://doi.org/10.1016/j.jaci.2021.12.260