Highly efficient intercellular spreading of protein misfolding mediated by viral ligand-receptor interactions

Autor: Shu Liu, André Hossinger, Stefanie-Elisabeth Heumüller, Annika Hornberger, Oleksandra Buravlova, Katerina Konstantoulea, Stephan A. Müller, Lydia Paulsen, Frederic Rousseau, Joost Schymkowitz, Stefan F. Lichtenthaler, Manuela Neumann, Philip Denner, Ina M. Vorberg

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

Pathologic protein aggregates associated with neurodegenerative diseases have the ability to transmit to unaffected cells via extracellular vesicles or direct cell-to-cell contact. Here, Liu et al. show that viral glycoproteins can contribute to inte

Externí odkaz: https://doaj.org/article/3c987601848e42e7821270559f3b20a9

Highly efficient intercellular spreading of protein misfolding mediated by viral ligand-receptor interactions

Autor: Shu Liu, Annika Hornberger, Katerina Konstantoulea, Philip Denner, Stefan F. Lichtenthaler, Stefanie-Elisabeth Heumüller, Lydia Paulsen, André Hossinger, Joost Schymkowitz, Frederic Rousseau, Ina Vorberg, Manuela Neumann, Oleksandra Buravlova, Stephan A. Müller

Publikováno v: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications 12(1), 5739 (2021). doi:10.1038/s41467-021-25855-2

Protein aggregates associated with neurodegenerative diseases have the ability to transmit to unaffected cells, thereby templating their own aberrant conformation onto soluble homotypic proteins. Proteopathic seeds can be released into the extracellu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c267871c21edbc58285a17a04aad283d
https://pubmed.ncbi.nlm.nih.gov/34667166

Fibril-induced glutamine-/asparagine-rich prions recruit stress granule proteins in mammalian cells

Autor: Shu Liu, Yvonne Duernberger, Katrin Riemschoss, Benedetta Bolognesi, Annika Hornberger, Oleksandra Buravlova, Stephan A. Müller, Lydia Paulsen, Ina Vorberg, Philipp von Eisenhart-Rothe, Stefan F. Lichtenthaler, André Hossinger, Gian Gaetano Tartaglia, Verena Arndt, Sebastian Hogl, Nieves Lorenzo-Gotor

Publikováno v: Life Science Alliance
Recercat. Dipósit de la Recerca de Catalunya
instname
Life science alliance 2(4), e201800280 (2019). doi:10.26508/lsa.201800280

This study provides evidence that exogenous proteinaceous seeds can induce protein aggregates that sequester stress granule components independent of stress granule assembly.
Prions of lower eukaryotes are self-templating protein aggregates that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::519833838ae0f8065a48060f79452133
http://hdl.handle.net/10230/42509