Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Oleksandr V. Borysov"'
Autor:
Sergiy V. Vlasov, Oleksandr V. Borysov, Hanna I. Severina, Vitaliy S. Vlasov, Amjad Ibrahim M. Abu Sharkh, Victoriya A. Georgiyants
Publikováno v:
Pharmacia, Vol 71, Iss , Pp 1-9 (2024)
According to the recent studies bezylcarboxamide fragment attached to the thiophene ring of thieno[2,3-d]pyrimidine is beneficial for antimicrobial activity of the compounds. Therefore we focused our efforts on constructing of the simple molecules su
Externí odkaz:
https://doaj.org/article/ce9e93a7a5f2435bbfa38454c4903f29
Autor:
Sergiy V. Vlasov, Oleksandr V. Borysov, Hanna I. Severina, Sergiy M. Kovalenko, Tetiana P. Osolodchenko, Vitaliy S. Vlasov, Victoriya A. Georgiyants
Publikováno v:
Журнал органічної та фармацевтичної хімії, Vol 19, Iss 3, Pp 15-20 (2021)
Aim. To synthesize, study the antimicrobial activity and suggest antimicrobial activity mechanism for the novel derivatives of 6-(1H-benzimidazol-2-yl)-5-methylthieno[2,3-d]pyrimidin-4(3H)-one. Results and discussion. As the result of the targeted m
Externí odkaz:
https://doaj.org/article/c248549c64f247df8e09fe7bbe25133d
Autor:
Sergiy V. Vlasov, Hanna I. Severina, Oleksandr V. Borysov, Konstantin Yu. Krolenko, Pavlo E. Shynkarenko, Narzullo B. Saidov, Vitaliy S. Vlasov, Victoriya A. Georgiyants
Publikováno v:
Molbank, Vol 2022, Iss 1, p M1331 (2022)
6-Heteryl-5-methylthieno[2,3-d]pyrimidin-2,4(1H,3H)-diones are of great interest as the promising objects for the search of antibacterials. In this communication, we obtained 6-(imidazo[1,2-a]pyridin-2-yl)-5-methyl-3-phenylthieno[2,3-d]pyrimidine-2,4
Externí odkaz:
https://doaj.org/article/b2760063f9f34bc0a06ca5df2dea66f6
Autor:
Sergiy V. Vlasov, Olena D. Vlasova, Hanna I. Severina, Konstantin Yu. Krolenko, Oleksandr V. Borysov, Amjad Ibrahim M. Abu Sharkh, Vitaliy S. Vlasov, Victoriya A. Georgiyants
Publikováno v:
Scientia Pharmaceutica, Vol 89, Iss 4, p 49 (2021)
The rapid development in bacterial resistance to many groups of known antibiotics forces the researchers to discover antibacterial drug candidates with previously unknown mechanisms of action, one of the most relevant being the inhibition of tRNA (Gu
Externí odkaz:
https://doaj.org/article/ec428ac290d44c679fa4056cb4cd25c3
Autor:
Victoriya Georgiyants, Oleksandr V. Borysov, Vitaliy S. Vlasov, Sergiy M. Kovalenko, Hanna I. Severina, Sergiy V. Vlasov, Tetiana P. Osolodchenko
Publikováno v:
Журнал органічної та фармацевтичної хімії, Vol 19, Iss 3, Pp 15-20 (2021)
Aim. To synthesize, study the antimicrobial activity and suggest antimicrobial activity mechanism for the novel derivatives of 6-(1H-benzimidazol-2-yl)-5-methylthieno[2,3-d]pyrimidin-4(3H)-one. Results and discussion. As the result of the targeted mo
Autor:
Vladimir I. Bozhanov, Dmytro P. Bohdan, Oleksandr V. Borysov, Aleksey V. Silin, Oleg V. Zaremba, Mykola M. Avramenko, Dmitriy M. Volochnyuk, Sergey V. Ryabukhin, Konstantin S. Gavrilenko
Publikováno v:
ChemistrySelect. 7
Autor:
Eduard B. Rusanov, Dmitriy M. Volochnyuk, Olesia V. Vasylets, Eugeniy Y. Slobodyanyuk, Maryana Y. Perebiynis, Oleksandr D. Tereshchenko, Irina V. Knysh, Sergey V. Ryabukhin, Oleksandr V. Borysov, Sergey V. Kolotilov, Anna A. Sorochenko
Publikováno v:
Advanced Synthesis & Catalysis. 362:3229-3242
Autor:
Oleksandr V. Borysov, Iulia Bakanovych, Yurii S. Moroz, Oleksandr O. Grygorenko, Yulia V Fil, Bohdan A. Chalyk, Kateryna V. Hrebeniuk, Pavlo S. Lebed, Bohdan V. Vashchenko, Alexander B. Rozhenko, Angelina V. Biitseva, Konstantin S. Gavrilenko
Publikováno v:
J Org Chem
A comprehensive study on the synthesis of 5-fluoroalkyl-substituted isoxazoles starting from functionalized halogenoximes is reported. One-pot metal-free [3 + 2] cycloaddition of CF3-substituted alkenes and halogenoximes bearing ester, bromo, chlorom
Autor:
Hanna I. Severina, Konstantin Yu. Krolenko, Sergiy V. Vlasov, Victoriya Georgiyants, Amjad Ibrahim M. Abu Sharkh, Olena D. Vlasova, Vitaliy S. Vlasov, Oleksandr V. Borysov
Publikováno v:
Scientia Pharmaceutica
Volume 89
Issue 4
Scientia Pharmaceutica, Vol 89, Iss 49, p 49 (2021)
Volume 89
Issue 4
Scientia Pharmaceutica, Vol 89, Iss 49, p 49 (2021)
The rapid development in bacterial resistance to many groups of known antibiotics forces the researchers to discover antibacterial drug candidates with previously unknown mechanisms of action, one of the most relevant being the inhibition of tRNA (Gu
2-Aminoquinazolin-4(3H)-one based plasmepsin inhibitors with improved hydrophilicity and selectivity
Autor:
Iveta Kanepe-Lapsa, Kristaps Jaudzems, Dace Rasina, Aigars Jirgensons, Oleksandr V. Borysov, Teodors Pantelejevs, Raitis Bobrovs, Georgijs Stakanovs, Kaspars Tars
Publikováno v:
Bioorganicmedicinal chemistry. 26(9)
2-Aminoquinazolin-4(3H)-ones were previously discovered as perspective leads for antimalarial drug development targeting the plasmepsins. Here we report the lead optimization studies with the aim to reduce inhibitor lipophilicity and increase selecti