Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Oleksandr Sverdlov"'
Autor:
Kerstine Carter, Olga Kuznetsova, Volodymyr Anisimov, Johannes Krisam, Colin Scherer, Yevgen Ryeznik, Oleksandr Sverdlov
Publikováno v:
BMC Medical Research Methodology, Vol 24, Iss 1, Pp 1-22 (2024)
Abstract Background When running a randomized controlled trial (RCT), a clinical site may face a situation when an eligible trial participant is to be randomized to the treatment that is not available at the site. In this case, there are two options:
Externí odkaz:
https://doaj.org/article/6409d535618d494eb89ff5cf9a7acc55
Autor:
Oleksandr Sverdlov, Yevgen Ryeznik, Volodymyr Anisimov, Olga M. Kuznetsova, Ruth Knight, Kerstine Carter, Sonja Drescher, Wenle Zhao
Publikováno v:
BMC Medical Research Methodology, Vol 24, Iss 1, Pp 1-23 (2024)
Abstract Background The design of a multi-center randomized controlled trial (RCT) involves multiple considerations, such as the choice of the sample size, the number of centers and their geographic location, the strategy for recruitment of study par
Externí odkaz:
https://doaj.org/article/69347b89448b4b2a859933c3f412fa5c
Autor:
Baltazar Gomez‐Mancilla, Jeffrey A. Levy, Subramanian Ganesan, Thomas Faller, Gil Issachar, Ziv Peremen, Offir Laufer, Revital Shani‐Hershkovich, Kostas Biliouris, Ela Walker, Mark P. Healy, Oleksandr Sverdlov, Sachin Desai, S. Nassir Ghaemi, Jang‐Ho Cha, Y. Gopi Shanker
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 11, Pp 2236-2252 (2023)
Abstract This single‐center study administered MIJ821 (onfasprodil) as an intravenous infusion to healthy volunteers and included two parts: a single ascending dose study (Part 1) and a repeated intravenous dose study (Part 2). Primary objective wa
Externí odkaz:
https://doaj.org/article/5df246e2bd1843acb8776d80c98f86a6
Publikováno v:
Frontiers in Clinical Diabetes and Healthcare, Vol 4 (2023)
IntroductionContinuous glucose monitoring (CGM) devices capture longitudinal data on interstitial glucose levels and are increasingly used to show the dynamics of diabetes metabolism. Given the complexity of CGM data, it is crucial to extract importa
Externí odkaz:
https://doaj.org/article/0b9d0c6469524d3d96058b394533bb20
Autor:
Yevgen Ryeznik, Oleksandr Sverdlov, Elin M. Svensson, Grace Montepiedra, Andrew C. Hooker, Weng Kee Wong
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 10, Pp 1134-1149 (2021)
Abstract Modern drug development problems are very complex and require integration of various scientific fields. Traditionally, statistical methods have been the primary tool for design and analysis of clinical trials. Increasingly, pharmacometric ap
Externí odkaz:
https://doaj.org/article/ed27afe540b74da88001b28b0e29afc4
Autor:
Vance W. Berger, Louis Joseph Bour, Kerstine Carter, Jonathan J. Chipman, Colin C. Everett, Nicole Heussen, Catherine Hewitt, Ralf-Dieter Hilgers, Yuqun Abigail Luo, Jone Renteria, Yevgen Ryeznik, Oleksandr Sverdlov, Diane Uschner, for the Randomization Innovative Design Scientific Working Group
Publikováno v:
BMC Medical Research Methodology, Vol 21, Iss 1, Pp 1-24 (2021)
Abstract Background Randomization is the foundation of any clinical trial involving treatment comparison. It helps mitigate selection bias, promotes similarity of treatment groups with respect to important known and unknown confounders, and contribut
Externí odkaz:
https://doaj.org/article/944d0ea49c0f4280b17832e126e27c27
Autor:
Jelena Curcic, Vanessa Vallejo, Jennifer Sorinas, Oleksandr Sverdlov, Jens Praestgaard, Mateusz Piksa, Mark Deurinck, Gul Erdemli, Maximilian Bügler, Ioannis Tarnanas, Nick Taptiklis, Francesca Cormack, Rebekka Anker, Fabien Massé, William Souillard-Mandar, Nathan Intrator, Lior Molcho, Erica Madero, Nicholas Bott, Mieko Chambers, Josef Tamory, Matias Shulz, Gerardo Fernandez, William Simpson, Jessica Robin, Jón G Snædal, Jang-Ho Cha, Kristin Hannesdottir
Publikováno v:
JMIR Research Protocols, Vol 11, Iss 8, p e35442 (2022)
BackgroundMore sensitive and less burdensome efficacy end points are urgently needed to improve the effectiveness of clinical drug development for Alzheimer disease (AD). Although conventional end points lack sensitivity, digital technologies hold pr
Externí odkaz:
https://doaj.org/article/e3350c32a2b146b7b2079f8e8be5bd3b
Publikováno v:
JMIR Formative Research, Vol 6, Iss 3, p e29154 (2022)
BackgroundAntipsychotic medications have limited benefits in schizophrenia, and cognitive behavioral therapy may be beneficial as an adjunct. There may be potential for implementing mobile cognitive behavioral therapy–based treatment for schizophre
Externí odkaz:
https://doaj.org/article/f63ab8e242c74a6f8e7d830af254735a
Autor:
Oleksandr Sverdlov, Jelena Curcic, Kristin Hannesdottir, Liangke Gou, Valeria De Luca, Francesco Ambrosetti, Bingsong Zhang, Jens Praestgaard, Vanessa Vallejo, Andrew Dolman, Baltazar Gomez-Mancilla, Konstantinos Biliouris, Mark Deurinck, Francesca Cormack, John J. Anderson, Nicholas T. Bott, Ziv Peremen, Gil Issachar, Offir Laufer, Dale Joachim, Raj R. Jagesar, Niels Jongs, Martien J. Kas, Ahnjili Zhuparris, Rob Zuiker, Kasper Recourt, Zoë Zuilhof, Jang-Ho Cha, Gabriel E. Jacobs
Publikováno v:
Frontiers in Psychiatry, Vol 12 (2021)
Background: Digital technologies have the potential to provide objective and precise tools to detect depression-related symptoms. Deployment of digital technologies in clinical research can enable collection of large volumes of clinically relevant da
Externí odkaz:
https://doaj.org/article/72fd564b566f4cc386cf603a160ea3ee
Autor:
Oleksandr Sverdlov, Yevgen Ryeznik
Publikováno v:
Applied Sciences, Vol 12, Iss 10, p 4952 (2022)
Background: Cognitive behavioral therapy (CBT) can be a useful treatment option for various mental health disorders. Modern advances in information technology and mobile communication enable delivery of state-of-the-art CBT programs via smartphones,
Externí odkaz:
https://doaj.org/article/e5e1b52002b148c3ba4576453f725863