Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Oleksandr Gakh"'
Autor:
Oleksandr Gakh, Jordan M. Wilkins, Yong Guo, Bogdan F. Popescu, Stephen D. Weigand, Alicja Kalinowska-Lyszczarz, Claudia F. Lucchinetti
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-14 (2024)
Abstract Multiple sclerosis (MS) is a leading cause of non-traumatic disability in young adults. The highly dynamic nature of MS lesions has made them difficult to study using traditional histopathology due to the specificity of current stains. This
Externí odkaz:
https://doaj.org/article/fd7c32d747bb4478823c32f309bb1bfd
Autor:
Jordan M. Wilkins, Oleksandr Gakh, Yong Guo, Bogdan Popescu, Nathan P. Staff, Claudia F. Lucchinetti
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Multiple sclerosis (MS) is the leading cause of non-traumatic disability in young adults. New avenues are needed to help predict individuals at risk for developing MS and aid in diagnosis, prognosis, and outcome of therapeutic treatments. Previously,
Externí odkaz:
https://doaj.org/article/c15759d936414759a19bd91d3a62f83f
Autor:
Mostafa Fekry, Wessen Alshokry, Przemysław Grela, Marek Tchórzewski, Eva-Christina Ahlgren, Christopher A Söderberg, Oleksandr Gakh, Grazia Isaya, Salam Al-Karadaghi
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0184961 (2017)
Frataxin is a highly conserved protein found in both prokaryotes and eukaryotes. It is involved in several central functions in cells, which include iron delivery to biochemical processes, such as heme synthesis, assembly of iron-sulfur clusters (ISC
Externí odkaz:
https://doaj.org/article/276fdaea55a847fbbeb8f205105b7a57
Autor:
Parijat Kabiraj, Charles L. Howe, Claudia F. Lucchinetti, W. Oliver Tobin, Christina B. McCarthy, Jordan Wilkins, Oleksandr Gakh
Publikováno v:
Aging (Albany NY)
Multiple sclerosis (MS) is a central nervous system inflammatory demyelinating disease and the most common cause of non-traumatic disability in young adults. Despite progress in the treatment of the active relapsing disease, therapeutic options targe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b2f87d92dc9e5bee80b6a3ed34ca24c
https://doi.org/10.18632/aging.103612
https://doi.org/10.18632/aging.103612
Autor:
Oleksandr Gakh, James R. Thompson, Douglas Y. Smith, Belinda K. Galeano, Grazia Isaya, Wasantha Ranatunga
Publikováno v:
Metallomics. 9:773-801
Early studies of the bacterial Fe-S cluster assembly system provided structural details for how the scaffold protein and the cysteine desulfurase interact. This work and additional work on the yeast and human systems elucidated a conserved mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fab9c8d9efee336475690452eb417fb
https://doi.org/10.1039/c7mt00089h
https://doi.org/10.1039/c7mt00089h
Autor:
Claudia F. Lucchinetti, W. Oliver Tobin, Parijat Kabiraj, Charles L. Howe, Oleksandr Gakh, Jordan Wilkins, Christina B. McCarthy
Publikováno v:
Aging. 13:7707-7707
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5499882f651d9ad3ed5a4ee50545658d
https://doi.org/10.18632/aging.202757
https://doi.org/10.18632/aging.202757
Autor:
Oleksandr Gakh, Wasantha Ranatunga, Eva-Christina Ahlgren, Douglas Y. Smith, James R. Thompson, Grazia Isaya, Salam Al-Karadaghi
Publikováno v:
Journal of Biological Chemistry. 291:21296-21321
Fe-S clusters, essential cofactors needed for the activity of many different enzymes, are assembled by conserved protein machineries inside bacteria and mitochondria. As the architecture of the human machinery remains undefined, we co-expressed in Es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfac91c33ef787f47c2ad7c70ee56901
https://doi.org/10.1074/jbc.m116.738542
https://doi.org/10.1074/jbc.m116.738542
Autor:
Grazia Isaya, Wasantha Ranatunga, Belinda K. Galeano, Salam Al-Karadaghi, Oleksandr Gakh, Douglas Y. Smith, Christopher A. G. Söderberg, James R. Thompson
Publikováno v:
Journal of Biological Chemistry. 291:10378-10398
The biosynthesis of Fe-S clusters is a vital process involving the delivery of elemental iron and sulfur to scaffold proteins via molecular interactions that are still poorly defined. We reconstituted a stable, functional complex consisting of the ir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::699597b77acb7637ccc81b9b25585094
https://doi.org/10.1074/jbc.m115.712414
https://doi.org/10.1074/jbc.m115.712414
Autor:
Grazia Isaya, Eva-Christina Ahlgren, Christopher G. Soderberg, Gregory A. Hunter, Salam Al-Karadaghi, Gloria C. Ferreira, Mallory E. Gillam, Oleksandr Gakh
Publikováno v:
Journal of Biological Chemistry. 291:11887-11898
Frataxin is a mitochondrial iron-binding protein involved in iron storage, detoxification, and delivery for iron sulfur-cluster assembly and heme biosynthesis. The ability of frataxin from different organisms to populate multiple oligomeric states in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41f6ab417b6211df0ca75764ce75a8f9
https://doi.org/10.1074/jbc.m115.701128
https://doi.org/10.1074/jbc.m115.701128
Autor:
Oleksandr, Gakh, Wasantha, Ranatunga, Belinda K, Galeano, Douglas S, Smith, James R, Thompson, Grazia, Isaya
Publikováno v:
Methods in enzymology. 595
Although Fe-S clusters may assemble spontaneously from elemental iron and sulfur in protein-free systems, the potential toxicity of free Fe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::98a882114d9ae8fa9d6fa1549b44c264
https://pubmed.ncbi.nlm.nih.gov/28882199
https://pubmed.ncbi.nlm.nih.gov/28882199