Zobrazeno 1 - 10
of 184
pro vyhledávání: '"Oleksandr Frei"'
Autor:
Olivia Wootton, Alexey A. Shadrin, Thomas Bjella, Olav B. Smeland, Dennis van der Meer, Oleksandr Frei, Kevin S. O’Connell, Torill Ueland, Ole A. Andreassen, Dan J. Stein, Shareefa Dalvie
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Cognitive impairment is a major determinant of functional outcomes in schizophrenia, however, understanding of the biological mechanisms underpinning cognitive dysfunction in the disorder remains incomplete. Here, we apply Genomic Structural
Externí odkaz:
https://doaj.org/article/7f13ff9d04ba4cabb368c63148f5460b
Autor:
Bayram Cevdet Akdeniz, Oleksandr Frei, Alexey Shadrin, Dmitry Vetrov, Dmitry Kropotov, Eivind Hovig, Ole A Andreassen, Anders M Dale
Publikováno v:
PLoS Genetics, Vol 20, Iss 8, p e1011372 (2024)
Genome-wide association studies (GWAS) implicate broad genomic loci containing clusters of highly correlated genetic variants. Finemapping techniques can select and prioritize variants within each GWAS locus which are more likely to have a functional
Externí odkaz:
https://doaj.org/article/23cff74853fb4eaeab378868e68ba4fa
Autor:
Sigrun Hope, Alexey A. Shadrin, Aihua Lin, Shahram Bahrami, Linn Rødevand, Oleksandr Frei, Saira J. Hübenette, Weiqiu Cheng, Guy Hindley, Heidi Nag, Line Ulstein, Magdalena Efrim-Budisteanu, Kevin O’Connell, Anders M. Dale, Srdjan Djurovic, Terje Nærland, Ole A. Andreassen
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Autism spectrum disorder (ASD) is a highly heritable condition with a large variation in cognitive function. Here we investigated the shared genetic architecture between cognitive traits (intelligence (INT) and educational attainment (EDU)),
Externí odkaz:
https://doaj.org/article/27f1d6ca47a5452fbc28d5c80e67f33c
Autor:
Lasse Bang, Shahram Bahrami, Guy Hindley, Olav B. Smeland, Linn Rødevand, Piotr P. Jaholkowski, Alexey Shadrin, Kevin S. O’ Connell, Oleksandr Frei, Aihua Lin, Zillur Rahman, Weiqiu Cheng, Nadine Parker, Chun C. Fan, Anders M. Dale, Srdjan Djurovic, Cynthia M. Bulik, Ole A. Andreassen
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Anorexia nervosa (AN) is a heritable eating disorder (50–60%) with an array of commonly comorbid psychiatric disorders and related traits. Although significant genetic correlations between AN and psychiatric disorders and related traits ha
Externí odkaz:
https://doaj.org/article/1504dcdb9170486786ab8df09684f946
Autor:
Markos Tesfaye, Piotr Jaholkowski, Guy F. L. Hindley, Alexey A. Shadrin, Zillur Rahman, Shahram Bahrami, Aihua Lin, Børge Holen, Nadine Parker, Weiqiu Cheng, Linn Rødevand, Oleksandr Frei, Srdjan Djurovic, Anders M. Dale, Olav B. Smeland, Kevin S. O’Connell, Ole A. Andreassen
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-18 (2023)
Abstract Background Irritable bowel syndrome (IBS) often co-occurs with psychiatric and gastrointestinal disorders. A recent genome-wide association study (GWAS) identified several genetic risk variants for IBS. However, most of the heritability rema
Externí odkaz:
https://doaj.org/article/d4cf61f95eec4b69bd69fd5c62edd34e
Autor:
Daniel Roelfs, Oleksandr Frei, Dennis van der Meer, Elleke Tissink, Alexey Shadrin, Dag Alnaes, Ole A. Andreassen, Lars T. Westlye, Tobias Kaufmann
Publikováno v:
BMC Psychiatry, Vol 23, Iss 1, Pp 1-7 (2023)
Abstract Psychiatric disorders are complex clinical conditions with large heterogeneity and overlap in symptoms, genetic liability and brain imaging abnormalities. Building on a dimensional conceptualization of mental health, previous studies have re
Externí odkaz:
https://doaj.org/article/19e4e7b8581d4980b2344b45747a766f
Developmental manifestations of polygenic risk for bipolar disorder from infancy to middle childhood
Autor:
Ragna Bugge Askeland, Laurie J. Hannigan, Kevin S. O’Connell, Elizabeth C. Corfield, Oleksandr Frei, Anita Thapar, George Davey Smith, Ted Reichborn-Kjennerud, Ole A. Andreassen, Helga Ask, Alexandra Havdahl
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Knowledge on how genetic risk for bipolar disorder manifests in developmental, emotional or behavioral traits during childhood is lacking. This issue is important to address to inform early detection and intervention efforts. We investigated
Externí odkaz:
https://doaj.org/article/485b0cfcb2454cb8b7b71cb3b2f84e94
Autor:
Asmundur Oddsson, Patrick Sulem, Gardar Sveinbjornsson, Gudny A. Arnadottir, Valgerdur Steinthorsdottir, Gisli H. Halldorsson, Bjarni A. Atlason, Gudjon R. Oskarsson, Hannes Helgason, Henriette Svarre Nielsen, David Westergaard, Juha M. Karjalainen, Hildigunnur Katrinardottir, Run Fridriksdottir, Brynjar O. Jensson, Vinicius Tragante, Egil Ferkingstad, Hakon Jonsson, Sigurjon A. Gudjonsson, Doruk Beyter, Kristjan H. S. Moore, Helga B. Thordardottir, Snaedis Kristmundsdottir, Olafur A. Stefansson, Solbritt Rantapää-Dahlqvist, Ida Elken Sonderby, Maria Didriksen, Pernilla Stridh, Jan Haavik, Laufey Tryggvadottir, Oleksandr Frei, G. Bragi Walters, Ingrid Kockum, Henrik Hjalgrim, Thorunn A. Olafsdottir, Geir Selbaek, Mette Nyegaard, Christian Erikstrup, Thorsten Brodersen, Saedis Saevarsdottir, Tomas Olsson, Kaspar Rene Nielsen, Asgeir Haraldsson, Mie Topholm Bruun, Thomas Folkmann Hansen, DBDS Genomic Consortium, Thora Steingrimsdottir, Rikke Louise Jacobsen, Rolv T. Lie, Srdjan Djurovic, Lars Alfredsson, Aitzkoa Lopez de Lapuente Portilla, Soren Brunak, Pall Melsted, Bjarni V. Halldorsson, Jona Saemundsdottir, Olafur Th. Magnusson, Leonid Padyukov, Karina Banasik, Thorunn Rafnar, Johan Askling, Lars Klareskog, Ole Birger Pedersen, Gisli Masson, Alexandra Havdahl, Bjorn Nilsson, Ole A. Andreassen, Mark Daly, Sisse Rye Ostrowski, Ingileif Jonsdottir, Hreinn Stefansson, Hilma Holm, Agnar Helgason, Unnur Thorsteinsdottir, Kari Stefansson, Daniel F. Gudbjartsson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Genotypes causing pregnancy loss and perinatal mortality are depleted among living individuals and are therefore difficult to find. To explore genetic causes of recessive lethality, we searched for sequence variants with deficit of homozygos
Externí odkaz:
https://doaj.org/article/a4fa595277a74ef2949c5d74d9c4032d
Autor:
Rune Boen, Tobias Kaufmann, Oleksandr Frei, Dennis van der Meer, Srdjan Djurovic, Ole A. Andreassen, Kaja K. Selmer, Dag Alnæs, Ida E. Sønderby
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-6 (2023)
Abstract The 15q11.2 BP1-BP2 copy number variant (CNV) is associated with altered brain morphology and risk for atypical development, including increased risk for schizophrenia and learning difficulties for the deletion. However, it is still unclear
Externí odkaz:
https://doaj.org/article/4c0a10f6958e408cba103abce4487686
Autor:
Dennis van der Meer, Tiril P. Gurholt, Ida E. Sønderby, Alexey A. Shadrin, Guy Hindley, Zillur Rahman, Ann-Marie G. de Lange, Oleksandr Frei, Olof D. Leinhard, Jennifer Linge, Rozalyn Simon, Dani Beck, Lars T. Westlye, Sigrun Halvorsen, Anders M. Dale, Tom H. Karlsen, Tobias Kaufmann, Ole A. Andreassen
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-10 (2022)
A GWAS study of European individuals uncovers genetic associations between whole-body MRI derived measures and cardiometabolic diseases and highlights the key role of liver fat in cardiometabolic health.
Externí odkaz:
https://doaj.org/article/ad41b0e9ff9a4483a5272677e670f9b7