Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Oleksandr Koniev"'
Autor:
Victor Lehot, Ondřej Lidický, Julien Most, Stéphane Erb, Igor Dovgan, Artem Osypenko, Oleksandr Koniev, Sergii Kolodych, Lenka Kotrchová, Guilhem Chaubet, Sarah Cianférani, Tomáš Etrych, Alain Wagner
Publikováno v:
ACS Omega, Vol 8, Iss 43, Pp 40508-40516 (2023)
Externí odkaz:
https://doaj.org/article/61547958d4c8422b851129ddc858ab8c
Publikováno v:
Bulletin of the National Technical University "KhPI". Series: Chemistry, Chemical Technology and Ecology. :103-112
Research is aimed at creating high-resource diamond-abrasive tools with a large-pore structure of the working layer, the use of which reduces the occurrence of grinding defects when processing materials sensitive to overheating. The formation of an o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b6722093084eaab6f7274c3fddeff67
https://doi.org/10.20998/2079-0821.2021.02.14
https://doi.org/10.20998/2079-0821.2021.02.14
Autor:
Alexandre Hentz, Margaux Riomet, Sébastien Delacroix, Oleksandr Koniev, Anthony Ehkirch, Sylvain Ursuegui, Igor Dovgan, Steve Hessmann, Alain Wagner, Frédéric Taran, Sergii Kolodych, Sarah Cianférani
Publikováno v:
Chemical Science
Chemical Science, The Royal Society of Chemistry, 2020, 11 (5), pp.1210-1215. ⟨10.1039/c9sc05468e⟩
Chemical Science, 2020, 11 (5), pp.1210-1215. ⟨10.1039/c9sc05468e⟩
Chemical Science, The Royal Society of Chemistry, 2020, 11 (5), pp.1210-1215. ⟨10.1039/c9sc05468e⟩
Chemical Science, 2020, 11 (5), pp.1210-1215. ⟨10.1039/c9sc05468e⟩
Controlled protein functionalization holds great promise for a wide variety of applications. However, despite intensive research, the stoichiometry of the functionalization reaction remains difficult to control due to the inherent stochasticity of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31bf58838833fe846bc28076937a26d7
https://hal.archives-ouvertes.fr/hal-03012248
https://hal.archives-ouvertes.fr/hal-03012248
On the use of DNA as a linker in antibody-drug conjugates: synthesis, stability and in vitro potency
Autor:
Oleksandr Koniev, Sylvain Ursuegui, Igor Dovgan, Marc Nothisen, Manon Ripoll, Sergii Kolodych, Isabelle Kuhn, Alain Wagner, Sarah Cianférani, Alexandre Hentz, Anthony Ehkirch, Victor Lehot
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports
Scientific Reports, Nature Publishing Group, 2020, 10 (1), ⟨10.1038/s41598-020-64518-y⟩
Scientific Reports
Scientific Reports, Nature Publishing Group, 2020, 10 (1), ⟨10.1038/s41598-020-64518-y⟩
Here we present the synthesis and evaluation of antibody-drug conjugates (ADCs), for which antibody and drug are non-covalently connected using complementary DNA linkers. These ADCs are composed of trastuzumab, an antibody targeting HER2 receptors ov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3a76953282b6adc6deb41770f2169ee
Autor:
Alain Wagner, Oleksandr Koniev, Sergii Kolodych, Brigitte Renoux, Jitka Eberova, Sarah Cianférani, Igor Dovgan, Sébastien Papot, Anthony Ehkirch
Publikováno v:
MedChemComm
MedChemComm, Royal Society of Chemistry, 2018, 9 (5), pp.827-830. ⟨10.1039/C8MD00141C⟩
MedChemComm, Royal Society of Chemistry, 2018, 9 (5), pp.827-830. ⟨10.1039/C8MD00141C⟩
The reduction–rebridging strategy is a powerful method for the preparation of stable and homogeneous antibody–drug conjugates (ADCs). In this communication, we describe the development of the arylene-dipropiolonitrile (ADPN) functional group for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08468553122dbd05aa7c93a4eba2e490
https://doi.org/10.1039/c8md00141c
https://doi.org/10.1039/c8md00141c
Autor:
Sabrina Bernard, Alain Wagner, Davide Audisio, Oleksandr Koniev, Sarah Bregant, Lucie Plougastel, Jijy Elyian, Elodie Decuypere, Sandra Gabillet, Sergii Kolodych, Frédéric Taran, Antoine Sallustrau, Margaux Riomet, Minh Nguyet Trinh, Ramar Arun Kumar
Publikováno v:
Angewandte Chemie International Edition. 56:15612-15616
We report the discovery of a new bioorthogonal click-and-release reaction involving iminosydnones and strained alkynes. This transformation leads to two products resulting from the ligation and fragmentation of iminosydnones under physiological condi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::101bfe47ded49f18254c715e0b3185e4
https://doi.org/10.1002/anie.201708790
https://doi.org/10.1002/anie.201708790
Publikováno v:
Bioconjugate chemistry. 30(10)
Antibody-oligonucleotide conjugates (AOCs) are a novel class of synthetic chimeric biomolecules that has been continually gaining traction in different fields of modern biotechnology. This is mainly due to the unique combination of the properties of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f18bb92899fca88919a2bbdf414b684f
https://pubmed.ncbi.nlm.nih.gov/31339691
https://pubmed.ncbi.nlm.nih.gov/31339691
Autor:
Alain Wagner, Sébastien Delacroix, Stéphane Erb, Samir Messaoudi, Stéphanie Nicolaÿ, Mouâd Alami, Riyadh Ahmed Atto AL-Shuaeeb, Sergii Kolodych, Jean-Daniel Brion, Sarah Cianférani, Jean-Christophe Cintrat, Oleksandr Koniev
Publikováno v:
Chemistry - A European Journal. 22:11365-11370
The third generation of aminobiphenyl palladacycle pre-catalyst "G3-Xantphos" enables functionalization of peptides containing cysteine in high yields. The conjugation (bioconjugation) occurs chemoselectively at room temperature under biocompatible c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee97e8f7e81132e53913087c6e72c1a7
https://doi.org/10.1002/chem.201602277
https://doi.org/10.1002/chem.201602277
Autor:
Oleksandr Koniev, Sergii Kolodych, Christian D. Muller, Brigitte Renoux, Sébastien Papot, Alain Wagner, Pauline Poinot, Wojciech Krezel, Jitka Eberova, Chloé Michel, Anthony Ehkirch, Sébastien Delacroix, Sarah Cianférani
Publikováno v:
European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2017, 142, pp.376-382. ⟨10.1016/j.ejmech.2017.08.008⟩
European Journal of Medicinal Chemistry, Elsevier, 2017, 142, pp.376-382. ⟨10.1016/j.ejmech.2017.08.008⟩
The selective destruction of tumour cells while sparing healthy tissues is one of the main challenges in cancer therapy. Antibody-drug conjugates (ADCs) are arguably the most rapidly expanding class of targeted cancer therapies. Efficient drug conjug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b06605d49a1d714852bcfc92d6a3a57
https://hal.archives-ouvertes.fr/hal-01649358
https://hal.archives-ouvertes.fr/hal-01649358
Autor:
Alain Van Dorsselaer, Sergii Kolodych, J.-Y. Bonnefoy, Sarah Cianférani, Alain Wagner, Jitka Eberova, Zoljargal Baatarkhuu, Johann Stojko, Oleksandr Koniev
Publikováno v:
Bioconjugate Chemistry. 26:1863-1867
Thiols are among the most frequently used functional groups in the field of bioconjugation. While there exists a variety of heterobifunctional reagents that allow for coupling thiols to other functions (e.g., amines, carboxylic acids), there is no sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cc73a17fcf271588c7d4d556747f5b5
https://doi.org/10.1021/acs.bioconjchem.5b00440
https://doi.org/10.1021/acs.bioconjchem.5b00440