Peroxisome proliferator-activated receptor α (PPARα) protects against oleate-induced INS-1E beta cell dysfunction by preserving carbohydrate metabolism

Autor: A. Usardi, Francesca Frigerio, Clarissa Bartley, Thierry Brun, Domenico Bosco, Kim Ravnskjaer, Pierre Maechler, Susanne Mandrup

Publikováno v: Diabetologia, Vol. 53, No 2 (2010) pp. 331-340
Frigerio, F, Brun, T, Bartley, C, Usardi, A, Bosco, D, Ravnskjær, K, Mandrup, S & Maechler, P 2009, ' Peroxisome proliferator-activated receptor alpha (PPARalpha) protects against oleate-induced INS-1E beta cell dysfunction by preserving carbohydrate metabolism ', Diabetologia, vol. 53, no. 2, pp. 331--340 . https://doi.org/10.1007/s00125-009-1590-6

Udgivelsesdato: 2009 AIMS/HYPOTHESIS: Pancreatic beta cells chronically exposed to fatty acids may lose specific functions and even undergo apoptosis. Generally, lipotoxicity is triggered by saturated fatty acids, whereas unsaturated fatty acids indu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83346b7c99e4b7c1b5430d04b199ba1b
https://doi.org/10.1007/s00125-009-1590-6

Cannabinoid receptor 1 and 2 agonists increase lipid accumulation in hepatocytes

Autor: De Gottardi, Andrea, Spahr, Laurent François Joséph, Ravier-Dall'Antonia, Florence, Hadengue, Antoine

Publikováno v: Liver International, Vol. 30, No 10 (2010) pp. 1482-1489

BACKGROUND: Cannabinoid receptors CB1 and CB2 are expressed in the liver, but their regulation in fatty hepatocytes is poorly documented. The aim of this study was to investigate the effects of selective CB1 or CB2 agonists on the expression of key r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1400::e8dd36951b9e07553f3bf5dd5bfe7b47
https://archive-ouverte.unige.ch/unige:20880

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