Výsledky vyhledávání - "Oleh V. Halkin"

Expression of IDE and PITRM1 genes in ERN1 knockdown U87 glioma cells: effect of hypoxia and glucose deprivation

Autor: Olena O. Khita, Olha V. Rudnytska, Oleksandr H. Minchenko, Oleh V. Halkin, Borys H. Bezrodnyi, Mykhailo M. Yakymchuk, Serhij V. Danilovskyi, Iryna V. Kryvdiuk, Dariia O. Tsymbal, Maria V. Smeshkova, Dmytro O. Minchenko

Publikováno v: Endocrine Regulations, Vol 54, Iss 3, Pp 183-195 (2020)

Objective. The aim of the present investigation was to study the expression of genes encoding polyfunctional proteins insulinase (insulin degrading enzyme, IDE) and pitrilysin metallopeptidase 1 (PITRM1) in U87 glioma cells in response to inhibition

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa434d87e63285cc2a097ec69ef80eb6
https://doi.org/10.2478/enr-2020-0021

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Effect of hypoxia on the expression of genes encoding insulin-like growth factors and some related proteins in U87 glioma cells without IRE1 function

Autor: Kharkova Ap, L L Karbovskyi, Oleksandr H. Minchenko, Oleh V. Halkin, Dmytro O. Minchenko

Publikováno v: Endocrine Regulations, Vol 50, Iss 2, Pp 43-54 (2016)

Objective. The aim of the present study was to investigate the effect of hypoxia on the expression of genes encoding insulin-like growth factors (IGF1 and IGF2), their receptor (IGF1R), binding protein-4 (IGFBP4), and stanniocalcin 2 (STC2) in U87 gl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05c61baa88fbabbe7438c931f5aeb051
https://doi.org/10.1515/enr-2016-0008

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IRE-1α regulates expression of ubiquitin specific peptidases during hypoxic response in U87 glioma cells

Autor: Dmytro O. Minchenko, Oleksandr H. Minchenko, Oleh V. Halkin, Oksana O. Ratushna, Dariia O. Tsymbal, O O Riabovol

Publikováno v: Endoplasmic Reticulum Stress in Diseases. 3

IRE-1α (inositol requiring enzyme-1α), the most evolutionarily conserved of the endoplasmic reticulum stress signaling pathways, is highly implicated in sustaining the proliferation of glioma cells and subsequent tumor growth, which is decreased by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::74dd4cdd7c36ab88997a44cc197fd815
https://doi.org/10.1515/ersc-2016-0003

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Inhibition of IRE1 signaling affects expression of a subset genes encoding for TNF-related factors and receptors and modifies their hypoxic regulation in U87 glioma cells

Autor: Dmytro O. Minchenko, Oleh V. Halkin, Oleksandr H. Minchenko, O O Riabovol, Iryna V. Kryvdiuk

Publikováno v: Endoplasmic Reticulum Stress in Diseases. 3

Inhibition of IRE1 (inositol requiring enzyme-1), the major signaling pathway of endoplasmic reticulum stress, significantly decreases tumor growth and proliferation of glioma cells. To elucidate the role of IRE1- mediated glioma growth, we studied t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf762ffd4605e56a7203c9ed6dcdf63f
https://doi.org/10.1515/ersc-2016-0001

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