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Akademický článek

Design of a methotrexate-controlled chemical dimerization system and its use in bio-electronic devices

Autor: Zhong Guo, Oleh Smutok, Wayne A. Johnston, Patricia Walden, Jacobus P. J. Ungerer, Thomas S. Peat, Janet Newman, Jake Parker, Tom Nebl, Caryn Hepburn, Artem Melman, Richard J. Suderman, Evgeny Katz, Kirill Alexandrov

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)

Efforts to engineer artificial allosteric systems are ongoing. Here the authors analyse factors influencing development of artificial small molecule:protein complexes that act as chemically induced dimerization (CID) systems; they use one of the CIDs

Externí odkaz: https://doaj.org/article/3137900910a3487b8be8037ec6136e0f

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Akademický článek

Smartphone-Adapted Multianalyte Biosensor Platform for Fluorescent Analysis of Human Biomarkers and Immunosuppressive Drugs Using PQQ- and NAD+-Dependent Enzymes

Autor: Oleh Smutok, Evgeny Katz

Publikováno v: Engineering Proceedings, Vol 35, Iss 1, p 33 (2023)

Here, we describe a multianalyte biosensor platform for the fluorescent analysis of different human state biomarkers (α-amylase, phenylalanine, glucose, lactate/pyruvate, alcohol) and some immunosuppressive drugs (cyclosporine A, tacrolimus, methotr

Externí odkaz: https://doaj.org/article/1df7554699034758935437ce9c741851

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Akademický článek

Biosensors: Electrochemical Devices—General Concepts and Performance

Autor: Oleh Smutok, Evgeny Katz

Publikováno v: Biosensors, Vol 13, Iss 1, p 44 (2022)

This review provides a general overview of different biosensors, mostly concentrating on electrochemical analytical devices, while briefly explaining general approaches to various kinds of biosensors, their construction and performance. A discussion

Externí odkaz: https://doaj.org/article/b7edf5cd242e486ebba83845ce6cc3be

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Akademický článek

Photo-stimulated self-powered electrochemical system for DNA release

Autor: Madeline Masi, Paolo Bollella, Oleh Smutok, Evgeny Katz

Publikováno v: Sensors and Actuators Reports, Vol 3, Iss , Pp 100058- (2021)

The DNA-release activated by light in the self-powered bioelectronic system has been studied. The system was composed of two connected electrodes: one photo-active electrode was modified with photosynthetic thylakoid membranes and another electrode w

Externí odkaz: https://doaj.org/article/6ea342571f554a70b5db01725b851b99

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Akademický článek

Biosensor Based on Peroxidase-Mimetic Nanozyme and Lactate Oxidase for Accurate L-Lactate Analysis in Beverages

Autor: Oleh Smutok, Taras Kavetskyy, Tetiana Prokopiv, Roman Serkiz, Ondrej Šauša, Ivan Novák, Helena Švajdlenková, Igor Maťko, Mykhailo Gonchar, Evgeny Katz

Publikováno v: Biosensors, Vol 12, Iss 11, p 1042 (2022)

Precision analysis of the key biological metabolites such as L-lactate has great practical importance for many technological processes in food technology, including beverage production. Here we describe a new, highly selective, and sensitive biosenso

Externí odkaz: https://doaj.org/article/c482a285830d44b89516249c13647f7c

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Akademický článek

The Potential Application of Magnetic Nanoparticles for Liver Fibrosis Theranostics

Autor: Aziz Eftekhari, Allahveirdy Arjmand, Ayyub Asheghvatan, Helena Švajdlenková, Ondrej Šauša, Huseyn Abiyev, Elham Ahmadian, Oleh Smutok, Rovshan Khalilov, Taras Kavetskyy, Magali Cucchiarini

Publikováno v: Frontiers in Chemistry, Vol 9 (2021)

Liver fibrosis is a major cause of morbidity and mortality worldwide due to chronic liver damage and leading to cirrhosis, liver cancer, and liver failure. To date, there is no effective and specific therapy for patients with hepatic fibrosis. As a r

Externí odkaz: https://doaj.org/article/9611c6125ee54222a62cd8c8adab5016

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Akademický článek

Flavocytochrome b2-Based Enzymatic Method of L-Lactate Assay in Food Products

Autor: Oleh Smutok, Maria Karkovska, Halyna Smutok, Mykhailo Gonchar

Publikováno v: The Scientific World Journal, Vol 2013 (2013)

L-lactate, a key metabolite of the anaerobic glycolytic pathway, plays an important role as a biomarker in medicine, in the nutritional sector and food quality control. For these reasons, there is a need for very specific, sensitive, and simple analy

Externí odkaz: https://doaj.org/article/df67b831bf4a4d08b918da535b0999db

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