Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Oleh Dzyubachyk"'
Publikováno v:
Journal of Imaging, Vol 10, Iss 7, p 172 (2024)
Deep-learning algorithms for cell segmentation typically require large data sets with high-quality annotations to be trained with. However, the annotation cost for obtaining such sets may prove to be prohibitively expensive. Our work aims to reduce t
Externí odkaz:
https://doaj.org/article/54909f79d8f54aa1987cc979550a3b43
Autor:
Yun Zhang, Jeremy A. Miller, Jeongbin Park, Boudewijn P. Lelieveldt, Brian Long, Tamim Abdelaal, Brian D. Aevermann, Tommaso Biancalani, Charles Comiter, Oleh Dzyubachyk, Jeroen Eggermont, Christoffer Mattsson Langseth, Viktor Petukhov, Gabriele Scalia, Eeshit Dhaval Vaishnav, Yilin Zhao, Ed S. Lein, Richard H. Scheuermann
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract With the advent of multiplex fluorescence in situ hybridization (FISH) and in situ RNA sequencing technologies, spatial transcriptomics analysis is advancing rapidly, providing spatial location and gene expression information about cells in
Externí odkaz:
https://doaj.org/article/e59c6e5249474f85a08d3e6a7931d55b
Autor:
Elsa C. Kuijper, Maurice Overzier, Ernst Suidgeest, Oleh Dzyubachyk, Cécile Maguin, Jean-Baptiste Pérot, Julien Flament, Yavuz Ariyurek, Hailiang Mei, Ronald A.M. Buijsen, Louise van der Weerd, Willeke van Roon-Mom
Publikováno v:
Neurobiology of Disease, Vol 190, Iss , Pp 106368- (2024)
In Huntington disease, cellular toxicity is particularly caused by toxic protein fragments generated from the mutant huntingtin (HTT) protein. By modifying the HTT protein, we aim to reduce proteolytic cleavage and ameliorate the consequences of muta
Externí odkaz:
https://doaj.org/article/0b4874be3df4497fb539494749184266
Autor:
Philippe C. Habets, Konstantinos Kalafatakis, Oleh Dzyubachyk, Steven J.A. van der Werff, Arlin Keo, Jamini Thakrar, Ahmed Mahfouz, Alberto M. Pereira, Georgina M. Russell, Stafford L. Lightman, Onno C. Meijer
Publikováno v:
Neurobiology of Stress, Vol 22, Iss , Pp 100514- (2023)
The characteristic endogenous circadian rhythm of plasma glucocorticoid concentrations is made up from an underlying ultradian pulsatile secretory pattern. Recent evidence has indicated that this ultradian cortisol pulsatility is crucial for normal e
Externí odkaz:
https://doaj.org/article/9eed16f9152f48aa90b190994bf42f39
Autor:
Julian Schlegel, Hans Liew, Katrin Rein, Oleh Dzyubachyk, Jürgen Debus, Amir Abdollahi, Martin Niklas
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101798- (2022)
Summary: We present a protocol for the biosensor Cell-Fit-HD4D. It enables long-term monitoring and correlation of single-cell fate with subcellular-deposited energy of ionizing radiation. Cell fate tracking using widefield time-lapse microscopy is u
Externí odkaz:
https://doaj.org/article/08a3a08b0c7743dfbf15198c38af86c6
Autor:
Boyd Kenkhuis, Antonios Somarakis, Lorraine de Haan, Oleh Dzyubachyk, Marieke E. IJsselsteijn, Noel F. C. C. de Miranda, Boudewijn P. F. Lelieveldt, Jouke Dijkstra, Willeke M. C. van Roon-Mom, Thomas Höllt, Louise van der Weerd
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-15 (2021)
Abstract Brain iron accumulation has been found to accelerate disease progression in amyloid-β(Aβ) positive Alzheimer patients, though the mechanism is still unknown. Microglia have been identified as key players in the disease pathogenesis, and ar
Externí odkaz:
https://doaj.org/article/3f4646cb0a074c658337fbd49da6c5aa
Transcriptomic Signatures Associated With Regional Cortical Thickness Changes in Parkinson’s Disease
Autor:
Arlin Keo, Oleh Dzyubachyk, Jeroen van der Grond, Jacobus J. van Hilten, Marcel J. T. Reinders, Ahmed Mahfouz
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Cortical atrophy is a common manifestation in Parkinson’s disease (PD), particularly in advanced stages of the disease. To elucidate the molecular underpinnings of cortical thickness changes in PD, we performed an integrated analysis of brain-wide
Externí odkaz:
https://doaj.org/article/d5a7af1035c84dc9bf48d196aaec0dc7
Autor:
Mandy Meijer, Arlin Keo, Judith M.C. van Leeuwen, Oleh Dzyubachyk, Onno C. Meijer, Christiaan H. Vinkers, Ahmed Mahfouz
Publikováno v:
Neurobiology of Stress, Vol 14, Iss , Pp 100307- (2021)
The biological mechanisms underlying inter-individual differences in human stress reactivity remain poorly understood. We aimed to identify the molecular underpinning of aberrant neural stress sensitivity in individuals at risk for schizophrenia. Lin
Externí odkaz:
https://doaj.org/article/c6ba5c1e0e724568860d687c04ec0407
Autor:
Gustavo Abreu-Vieira, Aashley S. D. Sardjoe Mishre, Jedrzej Burakiewicz, Laura G. M. Janssen, Kimberly J. Nahon, Jari A. van der Eijk, Titia T. Riem, Mariëtte R. Boon, Oleh Dzyubachyk, Andrew G. Webb, Patrick C. N. Rensen, Hermien E. Kan
Publikováno v:
Frontiers in Endocrinology, Vol 10 (2020)
Aim: Magnetic resonance imaging (MRI) is increasingly being used to evaluate brown adipose tissue (BAT) function. Reports on the extent and direction of cold-induced changes in MRI fat fraction and estimated BAT volume vary between studies. Here, we
Externí odkaz:
https://doaj.org/article/15a274d6c28646b1a78bc2da2a5f2bba
Autor:
Evgeni Aizenberg, Rosaline van den Berg, Zineb Ez-Zaitouni, Désirée van der Heijde, Monique Reijnierse, Oleh Dzyubachyk, Boudewijn P.F. Lelieveldt
Publikováno v:
BMC Medical Imaging, Vol 17, Iss 1, Pp 1-9 (2017)
Abstract Background Evaluating inflammatory changes over time on MR images of the spine in patients with suspected axial Spondyloarthritis (axSpA) can be a labor-intensive task, requiring readers to manually search for and perceptually align a set of
Externí odkaz:
https://doaj.org/article/c8259d57eb2a4f68b84cc0beb38293ba