Zobrazeno 1 - 10
of 159
pro vyhledávání: '"Oleh, Pochynyuk"'
Autor:
Kyrylo Pyrshev, Anna Stavniichuk, Viktor N. Tomilin, Naghmeh Hassanzadeh Khayyat, Guohui Ren, Mariya Kordysh, Oleg Zaika, Mykola Mamenko, Oleh Pochynyuk
Publikováno v:
Physiological Reports, Vol 11, Iss 6, Pp n/a-n/a (2023)
Abstract Mechanosensitive TRPV4 channel plays a dominant role in maintaining [Ca2+]i homeostasis and flow‐sensitive [Ca2+]i signaling in the renal tubule. Polycystic kidney disease (PKD) manifests as progressive cyst growth due to cAMP‐dependent
Externí odkaz:
https://doaj.org/article/3b29b6251de64c85af74876f3675b2e4
Autor:
Viktor N. Tomilin, Kyrylo Pyrshev, Anna Stavniichuk, Naghmeh Hassanzadeh Khayyat, Guohui Ren, Oleg Zaika, Sherif Khedr, Alexander Staruschenko, Fang C. Mei, Xiaodong Cheng, Oleh Pochynyuk
Publikováno v:
JCI Insight, Vol 7, Iss 3 (2022)
Exchange proteins directly activated by cAMP (Epacs) are abundantly expressed in the renal tubules. We used genetic and pharmacological tools in combination with balance, electrophysiological, and biochemical approaches to examine the role of Epac1 a
Externí odkaz:
https://doaj.org/article/c26be524f9554a00be999e91af072896
Autor:
Anna Stavniichuk, Kyrylo Pyrshev, Viktor N. Tomilin, Mariya Kordysh, Oleg Zaika, Oleh Pochynyuk
Publikováno v:
Biomolecules, Vol 13, Iss 1, p 177 (2023)
The renal collecting duct is known to play a critical role in many physiological processes, including systemic water–electrolyte homeostasis, acid–base balance, and the salt sensitivity of blood pressure. ClC-K2 (ClC-Kb in humans) is a Cl−-perm
Externí odkaz:
https://doaj.org/article/908bf37fabd84ce0a2655b415ca31203
Autor:
Oleh Pochynyuk, Oleg Palygin
Publikováno v:
Journal of the American Society of Nephrology : JASN. 33(8)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1e1688c2aef13f7c2fee03eafe564d3
https://pubmed.ncbi.nlm.nih.gov/35777784
https://pubmed.ncbi.nlm.nih.gov/35777784
Autor:
Anna Stavniichuk, Kyrylo Pyrshev, Oleg Zaika, Viktor N. Tomilin, Mariya Kordysh, Monika Lakk, David Križaj, Oleh Pochynyuk
Publikováno v:
American Journal of Physiology-Renal Physiology.
Ca2+-permeable TRPV4 channel serves as the sensor of tubular flow thus being well-suited to govern mechanosensitive K+ transport in the distal renal tubule. Here, we directly tested whether TRPV4 function is significant in affecting K+ balance. We em
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3cc545cc91abf9119cc6eb4d4128621b
https://doi.org/10.1152/ajprenal.00278.2022
https://doi.org/10.1152/ajprenal.00278.2022
Autor:
Jianxiang Xue, Linto Thomas, Jessica Dominguez Rieg, Viktor Tomilin, Oleh Pochynyuk, Timo Rieg
Publikováno v:
Physiology. 38
The sodium-hydrogen exchanger isoform 1 (NHE1) is a plasma membrane transporter with roles in transepithelial Na+/H+ transport, intracellular pH (pHi) and cell volume regulation. Within the kidney, NHE1 is previously documented to be expressed in all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::289be8459c18437b39180918c4854193
https://doi.org/10.1152/physiol.2023.38.s1.5729443
https://doi.org/10.1152/physiol.2023.38.s1.5729443
Publikováno v:
Physiology. 38
Hypertension is the major clinically relevant problem affecting millions of people in the US. The renal collecting duct is known to play a critical role in setting salt-sensitivity of blood pressure. Originally, the majority of clinical and basic eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5465a10b9fb6750529cbf675a9c94d72
https://doi.org/10.1152/physiol.2023.38.s1.5729528
https://doi.org/10.1152/physiol.2023.38.s1.5729528
Publikováno v:
Physiology. 38
Mechanical stress arising from elevated fluid flow is an important regulator of the water-electrolyte transport in the collecting duct (CD). It is well established that mechano-sensitive TRPV4 Ca2+-permeable channel mediates intracellular Ca2+ ([Ca2+
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c97ad2ac2c8e2c4d8d2b10eb622cea5e
https://doi.org/10.1152/physiol.2023.38.s1.5729575
https://doi.org/10.1152/physiol.2023.38.s1.5729575
Autor:
Kyrylo Pyrshev, Anna Stavniichuk, Viktor Tomilin, Mariya Kordysh, Oleg Zaika, Mykola Mamenko, Oleh Pochynyuk
Publikováno v:
Physiology. 38
Mechanosensitive Ca2+-permeable transient receptor potential vanilloid type 4 (TRPV4) channel plays a dominant role in maintaining intracellular Ca2+ ([Ca2+]i) homeostasis and flow-sensitive [Ca2+]i signaling in the distal segments of renal tubule an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0622f515705b2b6119403681c0bc003
https://doi.org/10.1152/physiol.2023.38.s1.5729507
https://doi.org/10.1152/physiol.2023.38.s1.5729507
Publikováno v:
Cells, Vol 10, Iss 6, p 1482 (2021)
Kidneys play a central role in regulation of potassium homeostasis and maintenance of plasma K+ levels within a narrow physiological range. With-no-lysine (WNK) kinases, specifically WNK1 and WNK4, have been recognized to regulate K+ balance, in part
Externí odkaz:
https://doaj.org/article/46ca22d1f9fd4c2a9f366656c2d3c2dd