Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Oleg V. Markov"'
Autor:
Kirill V. Odarenko, Aleksandra V. Sen’kova, Oksana V. Salomatina, Oleg V. Markov, Nariman F. Salakhutdinov, Marina A. Zenkova, Andrey V. Markov
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Soloxolone amides are semisynthetic triterpenoids that can cross the blood-brain barrier and inhibit glioblastoma growth both in vitro and in vivo. Here we investigate the impact of these compounds on processes associated with glioblastoma invasivene
Externí odkaz:
https://doaj.org/article/8bda56d571fa47af9a22c1eedf902d68
Autor:
Artem G. Fedorovskiy, Denis N. Antropov, Anton S. Dome, Pavel A. Puchkov, Daria M. Makarova, Maria V. Konopleva, Anastasiya M. Matveeva, Eugenia A. Panova, Elena V. Shmendel, Mikhail A. Maslov, Sergey E. Dmitriev, Grigory A. Stepanov, Oleg V. Markov
Publikováno v:
Pharmaceutics, Vol 16, Iss 5, p 684 (2024)
Over the past decade, mRNA-based therapy has displayed significant promise in a wide range of clinical applications. The most striking example of the leap in the development of mRNA technologies was the mass vaccination against COVID-19 during the pa
Externí odkaz:
https://doaj.org/article/fabd7a7db29d4126993439ce312d430e
Autor:
Timofey D. Zharkov, Oleg V. Markov, Sergey A. Zhukov, Svetlana N. Khodyreva, Maxim S. Kupryushkin
Publikováno v:
Molecules, Vol 29, Iss 2, p 452 (2024)
Numerous types of oligonucleotide modifications have been developed since automated synthesis of DNA/RNA became a common instrument in the creation of synthetic oligonucleotides. Despite the growing number of types of oligonucleotide modifications un
Externí odkaz:
https://doaj.org/article/3bcef87e6cb04dc7a30f8b46ce5cd0a3
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 24, p 17273 (2023)
Neutrophils are considered as the main player in innate immunity. In the last few years, it has been shown that they are involved in different physiological conditions and diseases. However, progress in the field of neutrophil biology is relatively s
Externí odkaz:
https://doaj.org/article/59f7d8bc76d542379e7b112442fbd935
Autor:
Timofey D. Zharkov, Ekaterina M. Mironova, Oleg V. Markov, Sergey A. Zhukov, Svetlana N. Khodyreva, Maxim S. Kupryushkin
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 19, p 14637 (2023)
Lipophilic oligonucleotide conjugates represent a powerful tool for nucleic acid cellular delivery, and many methods for their synthesis have been developed over the past few decades. In the present study, a number of chemical approaches for the synt
Externí odkaz:
https://doaj.org/article/a6cd213e133a4aa28164185514efc1bc
Autor:
Oleg V. Markov, Aleksandra V. Sen’kova, Islam S. Mohamed, Elena V. Shmendel, Mikhail A. Maslov, Anastasiya L. Oshchepkova, Evgeniy V. Brenner, Nadezhda L. Mironova, Marina A. Zenkova
Publikováno v:
Pharmaceutics, Vol 14, Iss 11, p 2542 (2022)
Cell-free antitumor vaccines represent a promising approach to immunotherapy of cancer. Here, we compare the antitumor potential of cell-free vaccines based on microvesicles derived from dendritic cells (DCs) with DC- and cationic-liposome-based vacc
Externí odkaz:
https://doaj.org/article/eb3ad4ee0c254b07bea709de01437fb6
Autor:
Islam Saber Ead Mohamed, Aleksandra V. Sen’kova, Oleg V. Markov, Andrey V. Markov, Innokenty A. Savin, Marina A. Zenkova, Nadezhda L. Mironova
Publikováno v:
Pharmaceutics, Vol 14, Iss 6, p 1173 (2022)
In this investigation, we extensively studied the mechanism of antitumor activity of bovine pancreatic RNase A. Using confocal microscopy, we show that after RNase A penetration into HeLa and B16 cells, a part of the enzyme remains unbound with the r
Externí odkaz:
https://doaj.org/article/3f3cae006e2e4858bf3bff7765acd96c
Autor:
Oleg V. Markov, Anton V. Filatov, Maxim S. Kupryushkin, Ivan V. Chernikov, Olga A. Patutina, Anton A. Strunov, Elena L. Chernolovskaya, Valentin V. Vlassov, Dmitrii V. Pyshnyi, Marina A. Zenkova
Publikováno v:
Molecules, Vol 25, Iss 16, p 3663 (2020)
Biological activity of antisense oligonucleotides (asON), especially those with a neutral backbone, is often attenuated by poor cellular accumulation. In the present proof-of-concept study, we propose a novel delivery system for asONs which implies t
Externí odkaz:
https://doaj.org/article/3f5085eb190c47098a7920bdfab5b453
Autor:
Alexander A. Lomzov, T. D. Zharkov, Maxim S. Kupryushkin, Svetlana N. Khodyreva, Ekaterina S Ilina, A. S. Kochetkova, M. M. Akhmetova, Olga I. Lavrik, D. V. Pyshnyi, Oleg V. Markov
Publikováno v:
Russian Journal of Bioorganic Chemistry. 47:719-733
In this work, representatives of the class of triazinylamidophosphate oligonucleotide derivatives were obtained for the first time. A scheme for the introduction of a modified unit on a solid-phase support during the oxidation step with highly reacti
Publikováno v:
Journal of Cancer Metastasis and Treatment.
Aim: We aimed to test the hypothesis that loading of dendritic cells (DCs) with both viral and tumor-specific antigens would enhance the efficacy antitumor DC-based therapy applied simultaneously with oncolytic virus. Methods: Vaccinia virus LIVP/GFP