Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Oleg Tolmachov"'
Publikováno v:
Briefings in bioinformatics. 22(4)
Chromatin immunoprecipitation followed by next-generation sequencing (ChIP-seq) is recognized as an extremely powerful tool to study the interaction of numerous transcription factors and other chromatin-associated proteins with DNA. The core problem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50168e5652234e6ef498fd84bff26dc5
https://pubmed.ncbi.nlm.nih.gov/33320934
https://pubmed.ncbi.nlm.nih.gov/33320934
Autor:
Oleg Tolmachov
Publikováno v:
Medical hypotheses. 132
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f0370b43f01940367fdf8d08689375e
https://pubmed.ncbi.nlm.nih.gov/31421422
https://pubmed.ncbi.nlm.nih.gov/31421422
Autor:
Oleg Tolmachov
Publikováno v:
Global Virology III: Virology in the 21st Century ISBN: 9783030290214
Many naturally occurring viral and bacterial gene transfer systems present ‘superinfection interference’ phenomena, where expression of additional viral genomes or bacterial plasmids in cells previously infected with a homologous virus or plasmid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::360da47fd6cbbe1b810378dd0d155201
https://doi.org/10.1007/978-3-030-29022-1_10
https://doi.org/10.1007/978-3-030-29022-1_10
Autor:
Oleg Tolmachov
Publikováno v:
Medical Hypotheses. 83:211-216
Tightly controlled spatial localisation of therapeutic gene delivery is essential to maximize the benefits of somatic gene therapy in vivo and to reduce its undesired effects on the ‘bystander' cell populations, most importantly germline cells. Ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0567281276e618b6f8b36f93943c2f03
https://doi.org/10.1016/j.mehy.2014.04.027
https://doi.org/10.1016/j.mehy.2014.04.027
Autor:
Robert E MacLaren, Nathan J. Walker, Samantha R. De Silva, Alun R. Barnard, Tanya Tolmachova, Miguel C. Seabra, Daniel M. Lipinski, Oleg Tolmachov
Publikováno v:
Journal of Molecular Medicine (Berlin, Germany)
Choroideremia (CHM) is an X-linked retinal degeneration of photoreceptors, the retinal pigment epithelium (RPE) and choroid caused by loss of function mutations in the CHM/REP1 gene that encodes Rab escort protein 1. As a slowly progressing monogenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82f83b4dedb2f71c7300957d72fcc975
http://europepmc.org/articles/PMC3695676
http://europepmc.org/articles/PMC3695676
Autor:
Oleg Tolmachov
Publikováno v:
Medical Hypotheses. 78:632-635
The cell-specific and long-term expression of therapeutic transgenes often requires a full array of native gene control elements including distal enhancers, regulatory introns and chromatin organisation sequences. The delivery of such extended gene e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c02edee4a057f57d4cf97509e375ef9c
https://doi.org/10.1016/j.mehy.2012.01.042
https://doi.org/10.1016/j.mehy.2012.01.042
Autor:
Dhani Tracey-White, Clare E. Futter, Oleg Tolmachov, Silène T. Wavre-Shapton, Tanya Tolmachova, Miguel C. Seabra
Publikováno v:
The Journal of Gene Medicine. 14:158-168
Background Choroideremia (CHM) is a progressive X-linked degeneration of three ocular layers: photoreceptors, retinal pigment epithelium (RPE) and choroid, caused by the loss of Rab Escort Protein-1 (REP1). As a recessive monogenic disorder, CHM is p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cc9430511f40536ba470d8337a37fe7
https://doi.org/10.1002/jgm.1652
https://doi.org/10.1002/jgm.1652
Autor:
Charles Coutelle, Oleg Tolmachov
Publikováno v:
Medical Hypotheses. 68:328-331
The generation of synthetic therapeutic gene vectors requires the coupling of DNA to transfer-promoting peptides including cellular receptor ligands, protein transduction domains, hydrophobic peptides for attachment to lipid membranes, nuclear locali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45aac585794c9e57f5723665389ee53d
https://doi.org/10.1016/j.mehy.2006.06.055
https://doi.org/10.1016/j.mehy.2006.06.055
Autor:
Oleg Tolmachov
Publikováno v:
Medical hypotheses. 85(5)
Gene delivery to human somatic cells is a well-established therapeutic strategy to treat a variety of diseases. In addition, gene transfer to human cells is required to generate human induced pluripotent cells and also to eliminate tumorigenic undiff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3c576964f0fc4a80263d7322c20da15
https://pubmed.ncbi.nlm.nih.gov/26319641
https://pubmed.ncbi.nlm.nih.gov/26319641
Autor:
Richard P. Harbottle, Oleg Tolmachov, Lisa G. Gregory, Charles Coutelle, Eric Perouzel, Laurence Vaysse
Publikováno v:
The Journal of Gene Medicine. 8:754-763
Background To develop more efficient non-viral vectors, we have previously described a novel approach to attach a nuclear localisation signal (NLS) to plasmid DNA, by generating a fusion protein between the tetracycline repressor protein TetR and an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77fe219c1987a1c60d4b801f7173b4b4
https://doi.org/10.1002/jgm.883
https://doi.org/10.1002/jgm.883