Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Oleg Shupliakov"'
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
The protein α-synuclein, which is well-known for its links to Parkinson’s Disease, is associated with synaptic vesicles (SVs) in nerve terminals. Despite intensive studies, its precise physiological function remains elusive. Accumulating evidence
Externí odkaz:
https://doaj.org/article/033c546321004a0d837e1a780e07b9d3
Autor:
Gianvito Arpino, Agila Somasundaram, Wonchul Shin, Lihao Ge, Seth Villareal, Chung Yu Chan, Uri Ashery, Oleg Shupliakov, Justin W. Taraska, Ling-Gang Wu
Publikováno v:
iScience, Vol 25, Iss 2, Pp 103809- (2022)
Summary: Clathrin-mediated endocytosis, the most prominent endocytic mode, is thought to be generated primarily from relatively flat patches of the plasma membrane. By employing conventional and platinum replica electron microscopy and super-resoluti
Externí odkaz:
https://doaj.org/article/b97afdad4fb9476ba4767ca24af811ab
Autor:
Roberta Filograna, Seungmin Lee, Katarína Tiklová, Mara Mennuni, Viktor Jonsson, Markus Ringnér, Linda Gillberg, Elena Sopova, Oleg Shupliakov, Camilla Koolmeister, Lars Olson, Thomas Perlmann, Nils-Göran Larsson
Publikováno v:
PLoS Genetics, Vol 17, Iss 9, p e1009822 (2021)
Dopamine (DA) neurons of the midbrain are at risk to become affected by mitochondrial damage over time and mitochondrial defects have been frequently reported in Parkinson's disease (PD) patients. However, the causal contribution of adult-onset mitoc
Externí odkaz:
https://doaj.org/article/61f2fcf7bb484163bdda169112e41b0e
Autor:
Arndt Pechstein, Nikolay Tomilin, Kristin Fredrich, Olga Vorontsova, Elena Sopova, Emma Evergren, Volker Haucke, Lennart Brodin, Oleg Shupliakov
Publikováno v:
Cell Reports, Vol 30, Iss 8, Pp 2594-2602.e3 (2020)
Summary: Liquid-liquid phase separation is an increasingly recognized mechanism for compartmentalization in cells. Recent in vitro studies suggest that this organizational principle may apply to synaptic vesicle clusters. Here we test this possibilit
Externí odkaz:
https://doaj.org/article/6cc1614f910b4b439cda1a0b1b860adb
Autor:
Wonchul Shin, Gianvito Arpino, Sathish Thiyagarajan, Rui Su, Lihao Ge, Zachary McDargh, Xiaoli Guo, Lisi Wei, Oleg Shupliakov, Albert Jin, Ben O’Shaughnessy, Ling-Gang Wu
Publikováno v:
Cell Reports, Vol 30, Iss 2, Pp 421-431.e7 (2020)
Summary: For decades, two fusion modes were thought to control hormone and transmitter release essential to life; one facilitates release via fusion pore dilation and flattening (full collapse), and the other limits release by closing a narrow fusion
Externí odkaz:
https://doaj.org/article/2e0c03cc3d67471682425f47514a1185
Autor:
Peter J. Wen, Staffan Grenklo, Gianvito Arpino, Xinyu Tan, Hsien-Shun Liao, Johanna Heureaux, Shi-Yong Peng, Hsueh-Cheng Chiang, Edaeni Hamid, Wei-Dong Zhao, Wonchul Shin, Tuomas Näreoja, Emma Evergren, Yinghui Jin, Roger Karlsson, Steven N. Ebert, Albert Jin, Allen P. Liu, Oleg Shupliakov, Ling-Gang Wu
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
As vesicles fuse to the plasma membrane, they form intermediate Ω-shaped structures followed by either closure of the pore or full merging with the plasma membrane. Here Wen et al. show that dynamic actin assembly provides membrane tension to promot
Externí odkaz:
https://doaj.org/article/18c51fe654d244e0aaf317965c19c8d0
Autor:
Charlotte F. Kelley, Emily M. Messelaar, Tania L. Eskin, Shiyu Wang, Kangkang Song, Kalanit Vishnia, Agata N. Becalska, Oleg Shupliakov, Michael F. Hagan, Dganit Danino, Olga S. Sokolova, Daniela Nicastro, Avital A. Rodal
Publikováno v:
Cell Reports, Vol 13, Iss 11, Pp 2597-2609 (2015)
F-BAR domain proteins regulate and sense membrane curvature by interacting with negatively charged phospholipids and assembling into higher-order scaffolds. However, regulatory mechanisms controlling these interactions are poorly understood. Here, we
Externí odkaz:
https://doaj.org/article/f4e783064bf04fd8931e25a2b98a39f3
Autor:
Lennart Brodin, Oleg Shupliakov
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 10 (2018)
The retromer complex mediates export of select transmembrane proteins from endosomes to the trans-Golgi network (TGN) or to the plasma membrane. Dysfunction of retromer has been linked with slowly progressing neurodegenerative disorders, including Al
Externí odkaz:
https://doaj.org/article/4137a16855d04fa78d9cc535269d2b2a
Autor:
Arndt Pechstein, Oleg Shupliakov
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 2 (2010)
Central inter-neuronal synapses employ various molecular mechanisms to sustain neurotransmitter release during phases of high-frequency synaptic activity. One of the features ensuring this property is the presence of a pool of synaptic vesicles (SVs)
Externí odkaz:
https://doaj.org/article/570f74a70d494d94b32493680a4391a7
Autor:
Konstantinos Meletis, Fanie Barnabé-Heider, Marie Carlén, Emma Evergren, Nikolay Tomilin, Oleg Shupliakov, Jonas Frisén
Publikováno v:
PLoS Biology, Vol 6, Iss 7, p e182 (2008)
Spinal cord injury often results in permanent functional impairment. Neural stem cells present in the adult spinal cord can be expanded in vitro and improve recovery when transplanted to the injured spinal cord, demonstrating the presence of cells th
Externí odkaz:
https://doaj.org/article/12e0b66476344eed8c722adf3eb1708d