Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Oleg S. Gorbatyuk"'
Autor:
Iuliia Dorofeeva, Assylbek Zhylkibayev, Irina V. Saltykova, Venkatram Atigadda, Bibek Adhikari, Oleg S. Gorbatyuk, Maria B. Grant, Marina S. Gorbatyuk
Publikováno v:
Cells, Vol 12, Iss 19, p 2361 (2023)
Previously, the RXR agonist UAB126 demonstrated therapeutic potential to treat obese mice by controlling blood glucose levels (BGL) and altering the expression of genes associated with lipid metabolism and inflammatory response. The purpose of the st
Externí odkaz:
https://doaj.org/article/683c4b8d60be40599fa098b4a29687b7
Autor:
Irina V. Saltykova, Asif Elahi, Priyam M. Pitale, Oleg S. Gorbatyuk, Mohammad Athar, Marina S. Gorbatyuk
Publikováno v:
Cell Death and Disease, Vol 12, Iss 7, Pp 1-11 (2021)
Abstract Various retinal degenerative disorders manifest in alterations of the AKT/mTOR axis. Despite this, consensus on the therapeutic targeting of mTOR in degenerating retinas has not yet been achieved. Therefore, we investigated the role of AKT/m
Externí odkaz:
https://doaj.org/article/25002a9dfab54246900542c58152fb09
Autor:
Oleg S. Gorbatyuk, Priyamvada M. Pitale, Irina V. Saltykova, Iuliia B. Dorofeeva, Assylbek A. Zhylkibayev, Mohammad Athar, Preston A. Fuchs, Brian C. Samuels, Marina S. Gorbatyuk
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2022)
Existing animal models with rod-dominant retinas have shown that hyperglycemia injures neurons, but it is not yet clearly understood how blue cone photoreceptors and retinal ganglion cells (RGCs) deteriorate in patients because of compromised insulin
Externí odkaz:
https://doaj.org/article/2fbdf25c0dc7417f9bf4bd7c1bead6e7
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 22, p 13748 (2022)
The UPR is sustainably activated in degenerating retinas, leading to translational inhibition via p-eIF2α. Recent findings have demonstrated that ablation of growth arrest and DNA damage-inducible protein 34 (GADD34), a protein phosphatase 1 regulat
Externí odkaz:
https://doaj.org/article/6045da93d80c4952be8902a0510dac23
Autor:
Shizuo Akira, Sergio Li Calzi, Yvonne Adu-Agyeiwaah, Priyamvada M Pitale, Maria B. Grant, W. Timothy Garvey, Takashi Satoh, Machelle T. Pardue, Irina V. Saltykova, Michael E. Boulton, Marina S. Gorbatyuk, Mohammad Athar, Oleg S. Gorbatyuk
Publikováno v:
Diabetes
The current understanding of the molecular pathogenesis of diabetic retinopathy does not provide a mechanistic link between early molecular changes and the subsequent progression of the disease. In this study, we found that human diabetic retinas ove
Autor:
Asif Elahi, Irina V. Saltykova, Priyam M Pitale, Marina S. Gorbatyuk, Mohammad Athar, Oleg S. Gorbatyuk
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 7, Pp 1-11 (2021)
Cell Death and Disease, Vol 12, Iss 7, Pp 1-11 (2021)
Various retinal degenerative disorders manifest in alterations of the AKT/mTOR axis. Despite this, consensus on the therapeutic targeting of mTOR in degenerating retinas has not yet been achieved. Therefore, we investigated the role of AKT/mTOR signa
Autor:
Michael E. Boulton, Marina S. Gorbatyuk, Oleg S. Gorbatyuk, Nahum Sonenberg, Yang Hu, Cyril Nii Amankwah Nyankerh, Christopher R. Starr, Xiaoping Qi
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose We reported previously that retinas of mice with inherited retinal degeneration make less protein than retinas of normal mice. Despite recent studies suggesting that diminished protein synthesis rates may contribute to neurologic disorders, a
Autor:
Héctor R. Méndez-Gómez, Oleg S. Gorbatyuk, Nicholas Muzyczka, Craig Meyers, Weijun Chen, Jasbir Singh
Publikováno v:
Neuroscience. 377:174-183
Phospholipase D2 (PLD2), an enzyme involved in vesicle trafficking and membrane signaling, interacts with α-synuclein, a protein known to contribute in the development of Parkinson disease (PD). We previously reported that PLD2 overexpression in rat
Publikováno v:
Prog Retin Eye Res
Physiological equilibrium in the retina depends on coordinated work between rod and cone photoreceptors and can be compromised by the expression of mutant proteins leading to inherited retinal degeneration (IRD). IRD is a diverse group of retinal dys
Autor:
Joseph C. Gully, Yogesh Bhootada, Héctor R. Méndez-Gómez, Marina S. Gorbatyuk, Sergey Zolotukhin, Valeriy Sergeyev, Craig Meyers, Oleg S. Gorbatyuk
Publikováno v:
Neuroscience Letters. 627:36-41
Activating transcription factor 4 (ATF4) is a member of the PERK signaling pathway, which directly binds endoplasmic reticulum stress target genes and plays a crucial role in both adaptations to stress and activation of apoptosis. Previous publicatio