Zobrazeno 1 - 10
of 179
pro vyhledávání: '"Oleg Krishtal"'
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2024)
Externí odkaz:
https://doaj.org/article/fc99ba389ec04ea5a5305f6f4410de69
Autor:
Yurii Tkachenko, Volodymyr Khmyz, Andrii Buta, Dmytro Isaev, Oleksandr Maximyuk, Oleg Krishtal
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Tissue acidification causes sustained activation of primary nociceptors, which causes pain. In mammals, acid-sensing ion channels (ASICs) are the primary acid sensors; however, Na+/H+ exchangers (NHEs) and TRPV1 receptors also contribute to tissue ac
Externí odkaz:
https://doaj.org/article/99934f250fb2442e867bd9ebd8f4bbad
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
It is well established that temperature affects the functioning of almost all biomolecules and, consequently, all cellular functions. Here, we show how temperature variations within a physiological range affect primary afferents’ spontaneous activi
Externí odkaz:
https://doaj.org/article/f4aab0fb301949bca756e31eadef3415
Autor:
Oleg Krishtal
Publikováno v:
BBA Advances, Vol 3, Iss , Pp 100087- (2023)
The author recalls several particularly memorable events during his scientific career that led to the discovery of acid-sensing ion channels and ionotropic purinergic receptors. The readers learn of the events of 1975 when the first intracellular per
Externí odkaz:
https://doaj.org/article/9a26da7f9b054cee9a525a5e28252612
Autor:
Xin Qi, Jian-Fei Lu, Zi-Yue Huang, Yi-Jun Liu, Lu-Bing Cai, Xin-Lan Wen, Xing-Lei Song, Jian Xiong, Pei-Yi Sun, Hao Zhang, Ting-Ting Zhang, Xuan Zhao, Qin Jiang, Ying Li, Oleg Krishtal, Leng-Chen Hou, Michael X. Zhu, Tian-Le Xu
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Acidosis is a hallmark of ischemic stroke and a promising neuroprotective target for preventing neuronal injury. Previously, genetic manipulations showed that blockade of acid-sensing ion channel 1a (ASIC1a)-mediated acidotoxicity could dramatically
Externí odkaz:
https://doaj.org/article/d3732aac90b844198f196b204024ea4e
Autor:
Olha Zapukhliak, Olga Netsyk, Artur Romanov, Oleksandr Maximyuk, Murat Oz, Gregory L Holmes, Oleg Krishtal, Dmytro Isaev
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0240074 (2021)
Cholinergic modulation of hippocampal network function is implicated in multiple behavioral and cognitive states. Activation of nicotinic and muscarinic acetylcholine receptors affects neuronal excitability, synaptic transmission and rhythmic oscilla
Externí odkaz:
https://doaj.org/article/fea50ab626c74d0b960a732da1bfe365
Publikováno v:
Neuroscience Bulletin. 39:845-862
Adenosine triphosphate (ATP) is well-known as a universal source of energy in living cells. Less known is that this molecule has a variety of important signaling functions: it activates a variety of specific metabotropic (P2Y) and ionotropic (P2X) re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a264cc9361f694c3fbd9ee828c96fed
https://doi.org/10.1007/s12264-022-00986-8
https://doi.org/10.1007/s12264-022-00986-8
Publikováno v:
Current Neuropharmacology. 19:1570-1589
Acid-sensing ion channels (ASICs) are Na+-permeable ion channels activated by protons and predominantly expressed in the nervous system. ASICs act as pH sensors leading to neuronal excitation. At least eight different ASIC subunits (including ASIC1a,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c695d42874de18ea4019aa8ba255bc7
https://doi.org/10.2174/1570159x19666210125151824
https://doi.org/10.2174/1570159x19666210125151824
Autor:
O. V. Iegorova, G. I. Kharytonenko, Oleg Krishtal, Tatyana Volkova, I.V. Chizhmakov, V. B. Kulyk, O. O. Drozd
Publikováno v:
Neurophysiology. 52:186-191
In this study, several properties of modulation of P2X3 currents by an endogenous opioid, leu-enkephalin (LEK), in neurons of the dorsal root and nodose ganglia (DRGs and NGs, respectively) were compared. P2X3-mediated currents were recorded using a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b84c764124cd61c77d6ef63daa6a054c
https://doi.org/10.1007/s11062-020-09869-y
https://doi.org/10.1007/s11062-020-09869-y
Publikováno v:
The Journal of Physiology. 598:1073-1092
Key points Central regulation of energy homeostasis and stress are believed to be reciprocally regulated, i.e. excessive food intake suppresses, while prolonged hunger exacerbates, stress responses in vivo. This relationship may be mediated by neuroe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcb53004c2173c55ba56172035d34528
https://doi.org/10.1113/jp279387
https://doi.org/10.1113/jp279387