Výsledky vyhledávání - "Oleg K, Glebov"

Akademický článek

Chromosomal Instability Is Associated with Higher Expression of Genes Implicated in Epithelial-Mesenchymal Transition, Cancer Invasiveness, and Metastasis and with Lower Expression of Genes Involved in Cell Cycle Checkpoints, DNA Repair, and Chromatin Maintenance

Autor: Anna V. Roschke, Oleg K. Glebov, Samir Lababidi, Kristen S. Gehlhaus, John N. Weinstein, Ilan R. Kirsch

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 10, Iss 11, Pp 1222-1230 (2008)

Chromosomal instability—a hallmark of epithelial cancers—is an ongoing process that results in aneuploidy and karyotypic heterogeneity of a cancer cell population. Previously, we stratified cancer cell lines in the NCI-60 drug discovery panel bas

Externí odkaz: https://doaj.org/article/704a83da020d4d53be9d5910974efe7c

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Integrated high-resolution array CGH and SKY analysis of homozygous deletions and other genomic alterations present in malignant mesothelioma cell lines

Autor: Paul S. Meltzer, Anna V. Roschke, Ilan R. Kirsch, Robert L. Walker, Yoonsoo Park, Ester Rozenblum, Geula Klorin, Frederic J. Kaye, Oleg K. Glebov

Publikováno v: Cancer Genetics. 206:191-205

High-resolution oligonucleotide array comparative genomic hybridization (aCGH) and spectral karyotyping (SKY) were applied to a panel of malignant mesothelioma (MMt) cell lines. SKY has not been applied to MMt before, and complete karyotypes are repo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67e85a51cc6c8726496a2adbe4634089
https://doi.org/10.1016/j.cancergen.2013.04.006

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Classical and/or alternative NF-κB pathway activation in multiple myeloma

Autor: P. Leif Bergsagel, Yulia N. Demchenko, W. Michael Kuehl, Jonathan J Keats, Oleg K. Glebov, Adriana Zingone

Publikováno v: Blood. 115:3541-3552

Mutations involving the nuclear factor-κB (NF-κB) pathway are present in at least 17% of multiple myeloma (MM) tumors and 40% of MM cell lines (MMCLs). These mutations, which are apparent progression events, enable MM tumors to become less dependen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0be84641cb872eec3b4ea75a26a0c2f3
https://doi.org/10.1182/blood-2009-09-243535

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A der(8)t(8;11) chromosome in the Karpas-620 myeloma cell line expresses only Cyclin D1: Yet both Cyclin D1 and MYC are repositioned in close proximity to the 3′ IGH enhancer

Autor: W. Michael Kuehl, Yaping Shou, Amel Dib, Oleg K. Glebov, Robert H. Singer

Publikováno v: DNA Repair. 8:330-335

The Karpas-620 human myeloma cell line (HMCL) expresses high levels of Cyclin D1 (CCND1), but has a der(8)t(8;11) and a der(14)t(8;14), and not a conventional t(11;14). Fluorescent in situ hybridization (FISH) and array comparative genomic hybridizat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11b542ab9250e61fd898ce95a357c49f
https://doi.org/10.1016/j.dnarep.2008.11.010

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Autor: Samir Lababidi, John N. Weinstein, Kristen Gehlhaus, Oleg K. Glebov, Anna V. Roschke, Ilan R. Kirsch

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 10, Iss 11, Pp 1222-1230 (2008)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2571e283323bac4b1af710c5aff642b
http://www.sciencedirect.com/science/article/pii/S147655860880019X

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Gene Expression Patterns Distinguish Colonoscopically Isolated Human Aberrant Crypt Foci from Normal Colonic Mucosa

Autor: Ilan R. Kirsch, Kenneth Nakahara, Oleg K. Glebov, Peter W. Soballe, John Denobile, Luz Rodriguez, Janet Cliatt

Publikováno v: Cancer Epidemiology, Biomarkers & Prevention. 15:2253-2262

Aberrant crypt foci (ACF) are considered the earliest identifiable preneoplastic colonic lesions; thus, a greater understanding of the nature of genetic changes underlying the transformation of normal colonic mucosa (NM) into ACF may provide insight

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a50ae5b99c8618bead9bc3a9ee52b473
https://doi.org/10.1158/1055-9965.epi-05-0694

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DNA mismatch-specific targeting and hypersensitivity of mismatch-repair-deficient cells to bulky rhodium(III) intercalators

Autor: Jonathan R. Hart, Ilan R. Kirsch, Russell J. Ernst, Jacqueline K. Barton, Oleg K. Glebov

Publikováno v: Proceedings of the National Academy of Sciences. 103:15359-15363

Mismatch repair (MMR) is critical to maintaining the integrity of the genome, and deficiencies in MMR are correlated with cancerous transformations. Bulky rhodium intercalators target DNA base mismatches with high specificity. Here we describe the ap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d51f9e07be665e385c92a6a33b26283
https://doi.org/10.1073/pnas.0607576103

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Characterization of MYC translocations in multiple myeloma cell lines

Autor: W. Michael Kuehl, Amel Dib, Ana Gabrea, Oleg K. Glebov, P. Leif Bergsagel

Publikováno v: Journal of the National Cancer Institute. Monographs. (39)

Translocations involving an MYC gene (c >> N >>L) are very late tumor progression events and provide a paradigm for secondary translocations in multiple myeloma. Using a combination of fluorescent in situ hybridization and comparative genomic hybridi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::267e55ed3c1f36120fe7d4176d44c792
https://pubmed.ncbi.nlm.nih.gov/18647998

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Genetic events in the pathogenesis of multiple myeloma

Autor: W.M. Kuehl, Wee Joo Chng, P.L. Bergsagel, Oleg K. Glebov

Publikováno v: Best practiceresearch. Clinical haematology. 20(4)

The genetics of myeloma has been increasingly elucidated in recent years. Recurrent genetic events, and also biologically distinct and clinically relevant genetic subtypes of myeloma have been defined. This has facilitated our understanding of the mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d15f7fa9843b6cb8f959aaafee5befb
https://pubmed.ncbi.nlm.nih.gov/18070707

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Celecoxib treatment alters the gene expression profile of normal colonic mucosa

Autor: Casey Jo Humbyrd, Gary Gordon, Jean Jenkins, Steven Gallinger, Oleg K. Glebov, Aby Buchbinder, Luz Rodriguez, Henry T. Lynch, Ilan R. Kirsch, Kenneth Nakahara, Janet Cliatt, Patrick M. Lynch, John Denobile, Sherri Patterson, Peter W. Soballe, Ernest T. Hawk

Publikováno v: Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 15(7)

A clinical trial was recently conducted to evaluate the safety and efficacy of a selective inhibitor of cyclooxygenase-2 (celecoxib) in hereditary nonpolyposis colon cancer patients. In a randomized, placebo-controlled phase I/II multicenter trial, h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9979bdb32a6c1743f9518bc5f6666800
https://pubmed.ncbi.nlm.nih.gov/16835340

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