Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Oleg Iartchouk"'
Autor:
Ye Wang, Morvarid Mohseni, Angelo Grauel, Javier Estrada Diez, Wei Guan, Simon Liang, Jiyoung Elizabeth Choi, Minying Pu, Dongshu Chen, Tyler Laszewski, Stephanie Schwartz, Jane Gu, Leandra Mansur, Tyler Burks, Lauren Brodeur, Roberto Velazquez, Steve Kovats, Bhavesh Pant, Giri Buruzula, Emily Deng, Julie T. Chen, Farid Sari-Sarraf, Christina Dornelas, Malini Varadarajan, Haiyan Yu, Chen Liu, Joanne Lim, Huai-Xiang Hao, Xiaomo Jiang, Anthony Malamas, Matthew J. LaMarche, Felipe Correa Geyer, Margaret McLaughlin, Carlotta Costa, Joel Wagner, David Ruddy, Pushpa Jayaraman, Nathaniel D. Kirkpatrick, Pu Zhang, Oleg Iartchouk, Kimberly Aardalen, Viviana Cremasco, Glenn Dranoff, Jeffrey A. Engelman, Serena Silver, Hongyun Wang, William D. Hastings, Silvia Goldoni
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-23 (2021)
Abstract SHP2 is a ubiquitous tyrosine phosphatase involved in regulating both tumor and immune cell signaling. In this study, we discovered a novel immune modulatory function of SHP2. Targeting this protein with allosteric SHP2 inhibitors promoted a
Externí odkaz:
https://doaj.org/article/aeca1d5b6b344aeabcc21b726ae4f617
Autor:
Angelo L. Grauel, Beverly Nguyen, David Ruddy, Tyler Laszewski, Stephanie Schwartz, Jonathan Chang, Julie Chen, Michelle Piquet, Marc Pelletier, Zheng Yan, Nathaniel D. Kirkpatrick, Jincheng Wu, Antoine deWeck, Markus Riester, Matt Hims, Felipe Correa Geyer, Joel Wagner, Kenzie MacIsaac, James Deeds, Rohan Diwanji, Pushpa Jayaraman, Yenyen Yu, Quincey Simmons, Shaobu Weng, Alina Raza, Brian Minie, Mirek Dostalek, Pavitra Chikkegowda, Vera Ruda, Oleg Iartchouk, Naiyan Chen, Raphael Thierry, Joseph Zhou, Iulian Pruteanu-Malinici, Claire Fabre, Jeffrey A. Engelman, Glenn Dranoff, Viviana Cremasco
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Understanding the tumor microenviroment is important before it can be exploited therapeutically. Here, the authors use single cell sequencing to study stromal cells in mouse tumors and identify a subset of interferon-licensed cancer associated fibrob
Externí odkaz:
https://doaj.org/article/55eb6b2ee746490ba919c1fb7bbcfb1d
Autor:
Zheng Yan, Raphael Thierry, Antoine deWeck, Claire Fabre, Felipe Correa Geyer, Joel Wagner, Oleg Iartchouk, Jeffrey A. Engelman, Beverly Nguyen, Rohan Diwanji, James Deeds, Julie Chen, Quincey Simmons, Naiyan Chen, Viviana Cremasco, Jonathan Chang, Joseph X. Zhou, Matt Hims, Yenyen Yu, Shaobu Weng, Pushpa Jayaraman, Stephanie Schwartz, David A. Ruddy, Michelle Piquet, Vera M. Ruda, Nathaniel D. Kirkpatrick, Pavitra Chikkegowda, Mirek Dostalek, Iulian Pruteanu-Malinici, Brian Minie, Glenn Dranoff, Markus Riester, Marc Pelletier, Alina Raza, Angelo Grauel, Kenzie MacIsaac, Jincheng Wu, Tyler Laszewski
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications
Despite the increasing interest in targeting stromal elements of the tumor microenvironment, we still face tremendous challenges in developing adequate therapeutics to modify the tumor stromal landscape. A major obstacle to this is our poor understan
Autor:
Reginald Valdez, Lin Fan, Yanqun Wang, Jiang Zhu, Sharon X. Wang, David J. Glass, Tea Shavlakadze, Joan Mannick, Weihua Zhou, Angelika Meyer, Oleg Iartchouk, Marc A. Egerman, Lloyd B. Klickstein, Bret Morin
Publikováno v:
The Journals of Gerontology: Series A. 73:845-852
Rapalogs, inhibitors of mTORC1 (mammalian target of rapamycin complex 1), increase life span and delay age-related phenotypes in many species. However, the molecular mechanisms have not been fully elucidated. We determined gene expression changes com
Autor:
Zachary Zwirko, Mina Mostafavi, Thomas W. Willis, Adriana K. Jones, Patrick Lee, Oleg Iartchouk, Srijan Ranjitkar, John R. Walker, S. Whitney Barnes, Charles R. Dean
Publikováno v:
Antimicrobial Agents and Chemotherapy. 63
Efflux pumps contribute to antibiotic resistance in Gram-negative pathogens. Correspondingly, efflux pump inhibitors (EPIs) may reverse this resistance. D13-9001 specifically inhibits MexAB-OprM in Pseudomonas aeruginosa Mutants with decreased suscep
Autor:
Natalia Kurepina, Sam Bozeman, Maha R. Farhat, Alexander Sloutsky, James E. Galagan, Elizabeth M. Streicher, Tommie C. Victor, Razvan Sultana, Megan Murray, Karen R. Jacobson, Barry N. Kreiswirth, Hanna Nebenzahl-Guimaraes, Robin M. Warren, Christian Stolte, Dick van Soolingen, Leen Rigouts, James E. Posey, Peter Sisk, Devinder Kaur, Oleg Iartchouk
Publikováno v:
American Journal of Respiratory and Critical Care Medicine, 194, 5, pp. 621-30
Europe PubMed Central
American Journal of Respiratory and Critical Care Medicine, 194, 621-30
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
American journal of respiratory and critical care medicine
Europe PubMed Central
American Journal of Respiratory and Critical Care Medicine, 194, 621-30
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
American journal of respiratory and critical care medicine
Item does not contain fulltext RATIONALE: The development of molecular diagnostics that detect both the presence of Mycobacterium tuberculosis in clinical samples and drug resistance-conferring mutations promises to revolutionize patient care and int
Autor:
Megan Murray, Douglas Wilson, Sunali Goonesekera, Meghan A Baker, Andreas Sandgren, Nisha Broodie, Kristina Wallengren, Oleg Iartchouk, Pardis C. Sabeti
Publikováno v:
The Journal of Infectious Diseases. 205:1043-1047
Background. We studied the association between iron intake and polymorphisms in the iron transporter gene SLC40A1 and the risk of tuberculosis. Methods. We compared iron intake, the frequency of SLC40A1 mutations, and interactions among these variabl
Autor:
Kimberly A Chin, Donald J. Zack, Nicholas Katsanis, Robyn Reynolds, Perciliz L. Tan, Peter A. Campochiaro, Kate T. Montgomery, Oleg Iartchouk, Stephan Ripke, Yi Yu, Betsy Campochiaro, Soumya Vemuri, Albert K. Tai, Soumya Raychaudhuri, Sivakumar Gowrisankar, Johanna M. Seddon, Mark J. Daly
Publikováno v:
Nature Genetics. 43:1232-1236
Two common variants in the gene encoding complement factor H (CFH), the Y402H substitution (rs1061170, c.1204C>T)(1-4) and the intronic rs1410996 SNP(5,6), explain 17% of age-related macular degeneration (AMD) liability. However, proof for the involv
Autor:
Christopher B. Ford, Nilofar Mohaideen, Marc Lipsitch, Rupal R. Shah, Philana Ling Lin, JoAnne L. Flynn, Sarah M. Fortune, James E. Galagan, Oleg Iartchouk, James C. Sacchettini, Thomas R. Ioerger, Michael R. Chase
Publikováno v:
Nature genetics
Mycobacterium tuberculosis (Mtb) has generated a global health catastrophe that has been compounded by the emergence of drug resistant Mtb strains. We used whole genome sequencing to compare the accumulation of mutations in Mtb isolated from cynomolg
Autor:
Yosuf Yassin, A. Thomas Look, Michael A. Caligiuri, Jordan M. Winter, Oleg Iartchouk, Mignon L. Loh, Ralph H. Hruban, Susan P. Whitman, Mohamed Bentires-Alj, Rupinder Grewal, Scott E. Kern, Kenneth D. Swanson, D. Gary Gilliland, Benjamin G. Neel, Kate Montgomery, Marcelo Reis, Charles J. Yeo, Matthew Meyerson, Raju Kucherlapati, Heidi Greulich
Publikováno v:
Genes, Chromosomes and Cancer. 47:253-259
Germ line gain-of-function mutations in several members of the RAS/ERK pathway, including PTPN11, KRAS, and RAF1, cause the autosomal dominant genetic disorder Noonan Syndrome (NS). NS patients are at increased risk of leukemia/myeloproliferative dis