Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Oleg Chen"'
Autor:
Catherine Delbrouck, Nicole Kiweler, Oleg Chen, Vitaly I. Pozdeev, Lara Haase, Laura Neises, Anaïs Oudin, Aymeric Fouquier d’Hérouël, Ruolin Shen, Lisa Schlicker, Rashi Halder, Antoine Lesur, Anne Schuster, Nadja I. Lorenz, Christian Jaeger, Maureen Feucherolles, Gilles Frache, Martyna Szpakowska, Andy Chevigne, Michael W. Ronellenfitsch, Etienne Moussay, Marie Piraud, Alexander Skupin, Almut Schulze, Simone P. Niclou, Elisabeth Letellier, Johannes Meiser
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113034- (2023)
Summary: Metabolic rewiring is essential for cancer onset and progression. We previously showed that one-carbon metabolism-dependent formate production often exceeds the anabolic demand of cancer cells, resulting in formate overflow. Furthermore, we
Externí odkaz:
https://doaj.org/article/d667e6854d774c98bcdedc3d5a151980
Autor:
Anna Dubrovska, Annett Linge, Michael Baumann, Mechthild Krause, Fabian Lohaus, Amir Abdollahi, Leoni A. Kunz-Schughart, Linda Hein, Adam A. Dowle, Christian Schwager, Barbara Klink, Joseph Porrmann, Stephan Heiden, Susan Richter, Graeme Eisenhofer, Bertram Aschenbrenner, Giulia Negro, Ira-Ida Skvortsova, Claudia Peitzsch, Ielizaveta Gorodetska, Steffen Löck, Oleg Chen, Anna Tyutyunnykova, Ina Kurth, David Digomann
Purpose:The heavy chain of the CD98 protein (CD98hc) is encoded by the SLC3A2 gene. Together with the light subunit LAT1, CD98hc constitutes a heterodimeric transmembrane amino acid transporter. High SLC3A2 mRNA expression levels are associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::350cd0679162cbd70da75dadecfce2ad
https://doi.org/10.1158/1078-0432.c.6526934.v1
https://doi.org/10.1158/1078-0432.c.6526934.v1
Autor:
Anna Dubrovska, Annett Linge, Michael Baumann, Mechthild Krause, Fabian Lohaus, Amir Abdollahi, Leoni A. Kunz-Schughart, Linda Hein, Adam A. Dowle, Christian Schwager, Barbara Klink, Joseph Porrmann, Stephan Heiden, Susan Richter, Graeme Eisenhofer, Bertram Aschenbrenner, Giulia Negro, Ira-Ida Skvortsova, Claudia Peitzsch, Ielizaveta Gorodetska, Steffen Löck, Oleg Chen, Anna Tyutyunnykova, Ina Kurth, David Digomann
Supplementary discussion; Supplementary methods; Supplementary tables S1-S8; Supplementary figures S1-S8.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::793de56158624f77bb8b4cecdc282520
https://doi.org/10.1158/1078-0432.22468433.v1
https://doi.org/10.1158/1078-0432.22468433.v1
Autor:
Anna, Mukha, Uğur, Kahya, Annett, Linge, Oleg, Chen, Steffen, Löck, Vasyl, Lukiyanchuk, Susan, Richter, Tiago C, Alves, Mirko, Peitzsch, Vladyslav, Telychko, Sergej, Skvortsov, Giulia, Negro, Bertram, Aschenbrenner, Ira-Ida, Skvortsova, Peter, Mirtschink, Fabian, Lohaus, Tobias, Hölscher, Hans, Neubauer, Mahdi, Rivandi, Vera, Labitzky, Tobias, Lange, André, Franken, Bianca, Behrens, Nikolas H, Stoecklein, Marieta, Toma, Ulrich, Sommer, Sebastian, Zschaeck, Maximilian, Rehm, Graeme, Eisenhofer, Christian, Schwager, Amir, Abdollahi, Christer, Groeben, Leoni A, Kunz-Schughart, Gustavo B, Baretton, Michael, Baumann, Mechthild, Krause, Claudia, Peitzsch, Anna, Dubrovska
Publikováno v:
Theranostics
Radiotherapy is one of the curative treatment options for localized prostate cancer (PCa). The curative potential of radiotherapy is mediated by irradiation-induced oxidative stress and DNA damage in tumor cells. However, PCa radiocurability can be i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::caa5c0d226a7838a27db2394ae5eb6bc
https://pubmed.ncbi.nlm.nih.gov/34335968
https://pubmed.ncbi.nlm.nih.gov/34335968
Autor:
Claudia Peitzsch, Giulia Negro, Mechthild Krause, Mirko Peitzsch, Marieta Toma, Fabian Lohaus, Tobias Hölscher, Sebastian Zschaeck, A Franken, Gustavo Baretton, Annett Linge, Nikolas H. Stoecklein, Tiago C. Alves, Anna Mukha, Mahdi Rivandi, Peter Mirtschink, Amir Abdollahi, Steffen Löck, Vladyslav Telychko, Christian Schwager, Oleg Chen, Susan Richter, Anna Dubrovska, Leoni A. Kunz-Schughart, Michael Baumann, Ulrich Sommer, Bertram Aschenbrenner, Bianca Behrens, Vasyl Lukiyanchuk, Maximilian Rehm, Ira-Ida Skvortsova, Hans Neubauer, Christer Groeben, Sergej Skvortsov, Uğur Kahya, Graeme Eisenhofer
Radiotherapy is one of the curative treatment options for localized prostate cancer (PCa). The curative potential of radiotherapy is mediated by irradiation-induced oxidative stress and DNA damage in tumor cells. However, PCa radiocurability can be i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68217130424b3f27e3f03f81acfccc81
https://doi.org/10.1101/2021.01.07.425771
https://doi.org/10.1101/2021.01.07.425771
Autor:
Leoni A. Kunz-Schughart, Adriana M. De Mendoza, Mechthild Krause, Oleg Chen, Lisa Eckhardt, Marit Wondrak, Soňa Michlíková, Damian D. McLeod
Publikováno v:
Cancers, Vol 13, Iss 3168, p 3168 (2021)
Cancers
Volume 13
Issue 13
Cancers 13(2021), 3168
Cancers
Volume 13
Issue 13
Cancers 13(2021), 3168
Simple Summary Resistance to therapy and subsequent relapse of the disease are common in patients with cancers in the head and neck region (HNSCC). Recent technological advancements have revitalized the concept of combining hyperthermia (HT) with rad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91b16c56af2ad0f6e51ad55a5ee57a62
http://oops.uni-oldenburg.de/5321/
http://oops.uni-oldenburg.de/5321/
Autor:
F. Manig, Michael Baumann, Oleg Chen, Oleh V. Stasyk, Zhanru Yu, Leoni A. Kunz-Schughart, Benedikt M. Kessler, Anna Dubrovska, Loreen Lehmann, Nagwa Sorour, Steffen Löck
Publikováno v:
Cellular and Molecular Life Sciences 78(2021), 3021-3044
Cellular and Molecular Life Sciences
Cellular and Molecular Life Sciences
Arginine deprivation therapy (ADT) is a new metabolic targeting approach with high therapeutic potential for various solid cancers. Combination of ADT with low doses of the natural arginine analog canavanine effectively sensitizes malignant cells to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df213edef1933636ae00b4bbabbdef14
https://www.hzdr.de/publications/Publ-33956-1
https://www.hzdr.de/publications/Publ-33956-1
Autor:
Joseph Porrmann, Ielizaveta Gorodetska, Graeme Eisenhofer, Steffen Löck, Amir Abdollahi, Anna Dubrovska, Annett Linge, Ina Kurth, Barbara Klink, Susan Richter, Adam Dowle, Christian Schwager, Michael Baumann, Oleg Chen, Ira-Ida Skvortsova, Fabian Lohaus, Bertram Aschenbrenner, Linda Hein, Leoni A. Kunz-Schughart, Mechthild Krause, Anna Tyutyunnykova, Stephan Heiden, David Digomann, Claudia Peitzsch, Giulia Negro
Publikováno v:
Clinical Cancer Research 25(2019)10, 3152-3163
Purpose: The heavy chain of the CD98 protein (CD98hc) is encoded by the SLC3A2 gene. Together with the light subunit LAT1, CD98hc constitutes a heterodimeric transmembrane amino acid transporter. High SLC3A2 mRNA expression levels are associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4830757e7956ee3ea6cbfb5f9a213b7e
https://pubmed.ncbi.nlm.nih.gov/30670494
https://pubmed.ncbi.nlm.nih.gov/30670494
Publikováno v:
Current medicinal chemistry. 25(21)
The paradoxical role of ER stress in malignant diseases is only just being unraveled and remains incompletely understood. A particular challenge is the complex interplay between spaciotemporal and locoregional microenvironmental constraints in solid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac81386dc0699a01aa809349047e31d3
https://pubmed.ncbi.nlm.nih.gov/29345569
https://pubmed.ncbi.nlm.nih.gov/29345569
Autor:
Anna Tyutyunnykova, Annett Linge, Mechthild Krause, Anna Dubrovska, Christer Groeben, M. Baumann, Oleg Chen, Ulrich Sommer, Claudia Peitzsch, Susan Richter
Publikováno v:
ESMO Open. 3:A272-A273
Introduction Pathophysiological conditions within the tumour microenvironment induce metabolic adaptations of cancer cells. These metabolic features correlating with aggressive tumour growth pattern and the relapse risk after radiotherapy. Beside glu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f5d303d904fe562092d9dfe5e668dfb
https://doi.org/10.1136/esmoopen-2018-eacr25.644
https://doi.org/10.1136/esmoopen-2018-eacr25.644