Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Oleg Bogachev"'
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Heart rate (HR) and sinoatrial node (SAN) function are modulated by the autonomic nervous system. HR regulation by the parasympathetic nervous system (PNS) is impaired in diabetes mellitus (DM), which is denoted cardiovascular autonomic neur
Externí odkaz:
https://doaj.org/article/20b47bddd0ec4edca7e1a4fced5a2816
Autor:
Martin Mackasey, BSc, Emmanuel E. Egom, MD, PhD, Hailey J. Jansen, PhD, Rui Hua, PhD, Motahareh Moghtadaei, PhD, Yingjie Liu, PhD, Jaspreet Kaur, PhD, Megan D. McRae, BHSc, Oleg Bogachev, MD, Sara A. Rafferty, MSc, Gibanananda Ray, PhD, Adam W. Kirkby, MSc, Robert A. Rose, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 3, Iss 6, Pp 824-843 (2018)
Summary: Sinoatrial node (SAN) disease mechanisms are poorly understood, and therapeutic options are limited. Natriuretic peptide(s) (NP) are cardioprotective hormones whose effects can be mediated partly by the NP receptor C (NPR-C). We investigated
Externí odkaz:
https://doaj.org/article/3896d8b4ee5d40c586211913311ef884
Publikováno v:
PLoS ONE, Vol 6, Iss 12 (2011)
Externí odkaz:
https://doaj.org/article/d548945e8438437eb40fdb1278caf718
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27795 (2011)
Adipocyte enhancer binding protein 1 (AEBP1) is a multifunctional protein that negatively regulates the tumor suppressor PTEN and IκBα, the inhibitor of NF-κB, through protein-protein interaction, thereby promoting cell survival and inflammation.
Externí odkaz:
https://doaj.org/article/6ecfec46546841959e86c3b10a8efc10
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
Heart rate (HR) and sinoatrial node (SAN) function are modulated by the autonomic nervous system. HR regulation by the parasympathetic nervous system (PNS) is impaired in diabetes mellitus (DM), which is denoted cardiovascular autonomic neuropathy. W
Autor:
Oleg Bogachev, Sara A. Rafferty, Yingjie Liu, Rui Hua, Hailey J. Jansen, Megan D. McRae, Motahareh Moghtadaei, Robert A. Rose, Adam W. Kirkby, Jaspreet Kaur, Gibanananda Ray, Emmanuel E. Egom, Martin Mackasey
Publikováno v:
JACC: Basic to Translational Science, Vol 3, Iss 6, Pp 824-843 (2018)
JACC: Basic to Translational Science
JACC: Basic to Translational Science
Visual Abstract
Highlights • SAN disease is prevalent in hypertension and heart failure and can be induced by chronic Ang II treatment in mice. • Ang II caused SAN disease in mice in association with impaired electrical conduction, reduction
Highlights • SAN disease is prevalent in hypertension and heart failure and can be induced by chronic Ang II treatment in mice. • Ang II caused SAN disease in mice in association with impaired electrical conduction, reduction
Autor:
Hailey J. Jansen, Susan E. Howlett, Oleg Bogachev, Martin Mackasey, Robert A. Rose, Sara A. Rafferty, John L. Sapp, Motahareh Moghtadaei
Publikováno v:
The Journal of Physiology. 594:7105-7126
Sinoatrial node (SAN) dysfunction increases with age, although not all older adults are affected in the same way. This is because people age at different rates and individuals of the same chronological age vary in health status from very fit to very
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Natriuretic peptides (NPs) play essential roles in the regulation of cardiovascular function. NP effects are mediated by receptors known as NPR-A, NPR-B or NPR-C. NPs have potent effects on regulation of heart rate (HR) by the autonomic nervous syste
Autor:
Robert A. Rose, Martin Mackasey, Oleg Bogachev, Hailey J. Jansen, Motahareh Moghtadaei, Pooja S. Krishnaswamy, Courtney Robbins, John Azer, Emmanuel E. Egom
Publikováno v:
Journal of Molecular and Cellular Cardiology. 82:125-135
Cardiovascular autonomic neuropathy (CAN) is a serious complication of diabetes mellitus that impairs autonomic regulation of heart rate (HR). This has been attributed to damage to the nerves that modulate spontaneous pacemaker activity in the sinoat
Autor:
Gibanananda Ray, Hailey J. Jansen, Martin Mackasey, Motahareh Moghtadaei, Sara A. Rafferty, Iuliia Polina, Oleg Bogachev, Emmanuel E. Egom, Kimberly Vella, Rhea Hurnik, Rui Hua, Robert A. Rose
Publikováno v:
The Journal of Physiology. 593:1127-1146
Natriuretic peptides (NPs) are critical regulators of the cardiovascular system that are currently viewed as possible therapeutic targets for the treatment of heart disease. Recent work demonstrates potent NP effects on cardiac electrophysiology, inc