Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Oleg A. Sineshchekov"'
Autor:
Takefumi Morizumi, Kyumhyuk Kim, Hai Li, Elena G. Govorunova, Oleg A. Sineshchekov, Yumei Wang, Lei Zheng, Éva Bertalan, Ana-Nicoleta Bondar, Azam Askari, Leonid S. Brown, John L. Spudich, Oliver P. Ernst
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Kalium channelrhodopsin 1 from Hyphochytrium catenoides (HcKCR1) is a light-gated channel used for optogenetic silencing of mammalian neurons. It selects K+ over Na+ in the absence of the canonical tetrameric K+ selectivity filter found univ
Externí odkaz:
https://doaj.org/article/4df751c792bb444bae38a92d509b0e3d
Publikováno v:
Biophysics and Physicobiology, Vol 20 (2023)
Since their discovery 21 years ago, channelrhodopsins have come of age and have become indispensable tools for optogenetic control of excitable cells such as neurons and myocytes. Potential therapeutic utility of channelrhodopsins has been proven by
Externí odkaz:
https://doaj.org/article/60ae3b0e30ae45f2995e7c4c5d63c21a
Autor:
Elena G. Govorunova, Oleg A. Sineshchekov, Leonid S. Brown, Ana-Nicoleta Bondar, John L. Spudich
Publikováno v:
mBio, Vol 13, Iss 6 (2022)
ABSTRACT Potassium-selective channelrhodopsins (KCRs) are light-gated K+ channels recently found in the stramenopile protist Hyphochytrium catenoides. When expressed in neurons, KCRs enable high-precision optical inhibition of spiking (optogenetic si
Externí odkaz:
https://doaj.org/article/6c367106a20741388c92353aaae743a9
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Channelrhodopsins (ChRs) are proteins that guide phototaxis in protists and exhibit light-gated channel conductance when their genes are heterologously expressed in mammalian cells. ChRs are widely used as molecular tools to control neurons and cardi
Externí odkaz:
https://doaj.org/article/b4eccaa5540c48518a48586fa578c475
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2022)
Cation and anion channelrhodopsins (CCRs and ACRs, respectively) from phototactic algae have become widely used as genetically encoded molecular tools to control cell membrane potential with light. Recent advances in polynucleotide sequencing, especi
Externí odkaz:
https://doaj.org/article/4732426eee32484f9f1c17bbb8bc6782
Autor:
Elena G. Govorunova, Oleg A. Sineshchekov, Hai Li, Yumei Wang, Leonid S. Brown, Alyssa Palmateer, Michael Melkonian, Shifeng Cheng, Eric Carpenter, Jordan Patterson, Gane K.-S. Wong, John L. Spudich
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
ABSTRACT Cation and anion channelrhodopsins (CCRs and ACRs, respectively) primarily from two algal species, Chlamydomonas reinhardtii and Guillardia theta, have become widely used as optogenetic tools to control cell membrane potential with light. We
Externí odkaz:
https://doaj.org/article/c53e961158494961a6504a84794cf01b
Autor:
Oleg A. Sineshchekov, Elena G. Govorunova, Hai Li, Yumei Wang, Michael Melkonian, Gane K.-S. Wong, Leonid S. Brown, John L. Spudich
Publikováno v:
mBio, Vol 11, Iss 2 (2020)
ABSTRACT Channelrhodopsins guide algal phototaxis and are widely used as optogenetic probes for control of membrane potential with light. “Bacteriorhodopsin-like” cation channelrhodopsins (BCCRs) from cryptophytes differ in primary structure from
Externí odkaz:
https://doaj.org/article/9e1672b12d674b958bd9f2860372ea25
Publikováno v:
Applied Sciences, Vol 10, Iss 18, p 6563 (2020)
This Special Issue provides an update for the rapidly developing technology known as “optogenetics” that is the use of genetically encoded light-sensitive molecular elements (usually derived from lower organisms) to control or report various phys
Externí odkaz:
https://doaj.org/article/f8c33b7ea5fd4e63b5fe76b132ef183f
Autor:
Elena G. Govorunova, Elena N. Spudich, C. Elizabeth Lane, Oleg A. Sineshchekov, John L. Spudich
Publikováno v:
mBio, Vol 2, Iss 3 (2011)
ABSTRACT Light control of motility behavior (phototaxis and photophobic responses) in green flagellate algae is mediated by sensory rhodopsins homologous to phototaxis receptors and light-driven ion transporters in prokaryotic organisms. In the photo
Externí odkaz:
https://doaj.org/article/a0b7e0ef8b354127a615c7c3ea2fe7fe
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Channelrhodopsins with red-shifted absorption, rare in nature, are highly desired for optogenetics because light of longer wavelengths more deeply penetrates biological tissue. RubyACRs (Anion ChannelRhodopsins), a group of four closely related anion