Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Oleg A. Igoshin"'
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109235- (2024)
Summary: All proteins are translated in the cytoplasm, yet many, including transcription factors, play vital roles in the nucleus. While previous research has concentrated on molecular motors for the transport of these proteins to the nucleus, recent
Externí odkaz:
https://doaj.org/article/a0bb609d6b9a406ebec59a4d03136870
Autor:
Patrick Murphy, Jessica Comstock, Trosporsha Khan, Jiangguo Zhang, Roy Welch, Oleg A. Igoshin
Publikováno v:
mSystems, Vol 8, Iss 5 (2023)
ABSTRACT The soil bacterium Myxococcus xanthus is a model organism with a set of diverse behaviors. These behaviors include the starvation-induced multicellular development program, in which cells move collectively to assemble multicellular aggregate
Externí odkaz:
https://doaj.org/article/3c8a942027dd42b89719dca7deec0277
Publikováno v:
mSystems, Vol 8, Iss 2 (2023)
ABSTRACT In Bacillus subtilis, master regulator Spo0A controls several cell-differentiation pathways. Under moderate starvation, phosphorylated Spo0A (Spo0A~P) induces biofilm formation by indirectly activating genes controlling matrix production in
Externí odkaz:
https://doaj.org/article/5370253574514567a5de65a6b516fa30
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Gene expression noise can reduce fitness but analysis is hampered by a scaling relationship between noise and expression level. Here the authors show that gene expression mean and noise can be independently controlled by expressing two copies of a ge
Externí odkaz:
https://doaj.org/article/37132251cd3a4015b9689403fd278277
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Transient plasmid transfection produces a wide distribution of copy numbers and expression heterogeneity. Here the authors present synthetic circuits called Equalizers that buffer copy number variation at the single-cell level and minimize cell-to-ce
Externí odkaz:
https://doaj.org/article/3624485f7c5c49edb625fe43b2b5f8d9
Autor:
Zhuo Chen, Priyanka Srivastava, Brenda Zarazúa-Osorio, Anuradha Marathe, Masaya Fujita, Oleg A. Igoshin
Publikováno v:
mBio, Vol 13, Iss 1 (2022)
ABSTRACT In Bacillus subtilis, biofilm and sporulation pathways are both controlled by a master regulator, Spo0A, which is activated by phosphorylation via a phosphorelay—a cascade of phosphotransfer reactions commencing with autophosphorylation of
Externí odkaz:
https://doaj.org/article/3b1ffe509f884d289ee4d20f0410e695
Autor:
Rajesh Balagam, Pengbo Cao, Govind P. Sah, Zhaoyang Zhang, Kalpana Subedi, Daniel Wall, Oleg A. Igoshin
Publikováno v:
mSystems, Vol 6, Iss 6 (2021)
ABSTRACT A wide range of biological systems, from microbial swarms to bird flocks, display emergent behaviors driven by coordinated movement of individuals. To this end, individual organisms interact by recognizing their kin and adjusting their motil
Externí odkaz:
https://doaj.org/article/ca43289edc394db7b13d8a6f226fe59c
Autor:
Sebastian M. Castillo-Hair, Elliot A. Baerman, Masaya Fujita, Oleg A. Igoshin, Jeffrey J. Tabor
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Bacillus subtilis has complex spatial and temporal gene expression patterns but currently lacks optogenetic tools to explore these processes. Here the authors import and debug a cyanobacterial green light sensor pathway and show that it enables preci
Externí odkaz:
https://doaj.org/article/3e7f5ad0191741118843857e0ec93057
Publikováno v:
mSystems, Vol 6, Iss 1 (2021)
ABSTRACT Dynamical properties of gene regulatory networks are tuned to ensure bacterial survival. In mycobacteria, the MprAB-σE network responds to the presence of stressors, such as surfactants that cause surface stress. Positive feedback loops in
Externí odkaz:
https://doaj.org/article/e83c4c1c519741afadfbad51385aedfc
Publikováno v:
mSystems, Vol 5, Iss 4 (2020)
ABSTRACT Single mutations frequently alter several aspects of cell behavior but rarely reveal whether a particular statistically significant change is biologically significant. To determine which behavioral changes are most important for multicellula
Externí odkaz:
https://doaj.org/article/2269b62faf9e4ff69dc69a52084ab004