Aminoalkylindoles: Structure-Activity Relationships of Novel Cannabinoid Mimetics

Autor: Malcolm R. Bell, Eissenstat Ma, E. J. Alexander, Olefirowicz Em, James H. Ackerman, Gruett, Thomas E. D'Ambra, Kumar, Sol J. Daum, Estep Kg

Publikováno v: Journal of Medicinal Chemistry. 38:3094-3105

Aminoalkylindoles (AAIs) are a novel series of cannabinoid receptor ligands. In this report we disclose the structural features of AAIs which are important for binding to this receptor as measured by inhibition of binding of [ 3 H]Win 55212-2 (5). Fu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc7ed5c57cee63b2a01fc4e34b76e307
https://doi.org/10.1021/jm00016a013

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Aminoalkylindoles: structure-activity relationships of novel cannabinoid mimetics.

Autor: Eissenstat MA; Department of Medicinal Chemistry, Sanofi Research Division, Sanofi Winthrop Inc., Collegeville, Pennsylvania 19426-0900, USA., Bell MR, D'Ambra TE, Alexander EJ, Daum SJ, Ackerman JH, Gruett MD, Kumar V, Estep KG, Olefirowicz EM, et. al.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 1995 Aug 04; Vol. 38 (16), pp. 3094-105.

Conformationally restrained aminoalkylindoles: potent, stereoselective ligands at the cannabinoid binding site.

Autor: Estep KG; Department of Medicinal Chemistry, Sterling Research Group, Rensselaer, NY 12144., D'Ambra TE, Olefirowicz EM, Bell MR, Eissenstat MA, Haycock DA, Ward SJ

Publikováno v: NIDA research monograph [NIDA Res Monogr] 1990; Vol. 105, pp. 300-1.