Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Ole Vesterqvist"'
Publikováno v:
Journal of Chromatography B. 821:159-165
A sensitive method for quantitation of urinary 6beta-hydroxycortisol (6beta-HC) and cortisol using on-line SPE and LC-MS/MS was developed and validated. Human urine samples were injected directly onto an on-line solid phase extraction apparatus, Pros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f207f332466a6798bc774220d845606
https://doi.org/10.1016/j.jchromb.2005.04.030
https://doi.org/10.1016/j.jchromb.2005.04.030
Autor:
Dean W. Knuth, Ole Vesterqvist, Russ S. Weiner, Sunil Kadam, John A. Wagner, Ronald R. Bowsher, Timothy J. O'Leary, Jean W. Lee, Holly Soares, James L. Witliff, Jeff M. Sailstad, Peter J. O'Brien, Lini Pandite, Herbert A. Fritche, Valerie Quarmby, Jean L. Fourcroy, Robert G. Pietrusko, Lorah Perlee, David M. Potter, Rakesh Dixit
Publikováno v:
Pharmaceutical Research. 22:499-511
Biomarkers are increasingly used in drug development to aid scientific and clinical decisions regarding the progress of candidate and marketed therapeutics. Biomarkers can improve the understanding of diseases as well as therapeutic and off-target ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2b9215738669408ffb799fb2d20875b
https://doi.org/10.1007/s11095-005-2495-9
https://doi.org/10.1007/s11095-005-2495-9
Autor:
Howard Uderman, BN Swanson, Neville F. Ford, Irene Ferreira, Ole Vesterqvist, Wei‐chi Liao, Carol L. Delaney, Mohammed Jemal
Publikováno v:
British Journal of Clinical Pharmacology. 56:395-406
Aims To determine the pharmacokinetics, pharmacodynamics and tolerability of omapatrilat, a vasopeptidase inhibitor, in healthy subjects. Methods The effects of oral omapatrilat were evaluated in healthy men in two double-blind, placebo-controlled, d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ddacab35454082c0a8c76f0e97504856
https://doi.org/10.1046/j.1365-2125.2003.01888.x
https://doi.org/10.1046/j.1365-2125.2003.01888.x
Autor:
Vito M. Campese, Wei-chi Liao, Bridget Brosnihan, Clarence E. Grim, Carlos M. Ferrario, Ole Vesterqvist, Michael C. Ruddy, Mark C. Chappell, Ronald D. Smith
Publikováno v:
American Journal of Hypertension. 15:557-564
The contribution of angiotensin-(1-7) [Ang-(1-7)] to the antihypertensive actions of omapatrilat, a novel vasopeptidase inhibitor, was evaluated in 22 salt-sensitive, low renin, hypertensive subjects as a substudy of a multicenter randomized, double-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73100a7eddb17d029f99d3d7c300c18a
https://doi.org/10.1016/s0895-7061(02)02268-9
https://doi.org/10.1016/s0895-7061(02)02268-9
Autor:
Marc Klapholz, Georgia D. Kollia, Wei-Chi Liao, Carol L. Delaney, Ole Vesterqvist, John B. Kostis, Marvin Cohen, Mohammed Jemal, James A. Manning
Publikováno v:
The Journal of Clinical Pharmacology. 41:1280-1290
The purpose of this study was to determine the pharmacodynamics and pharmacokinetics of omapatrilat, administered orally (25 mg) or intravenously (10 mg) in 19 New York Heart Association class II and class III congestive heart failure (CHF) patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::473e466bbba700d03cf3f6d99adf90b1
https://doi.org/10.1177/00912700122012869
https://doi.org/10.1177/00912700122012869
Autor:
Carol L. Delaney, Kenneth C. Lasseter, Wei-Chi Liao, Vito M. Campese, Ramon Vargas, Carlos M. Ferrario, Clarence E. Grim, Michael C. Ruddy, William B. Smith, Ole Vesterqvist, Michael F. Habashy, Ronald D. Smith
Publikováno v:
Hypertension. 38:1342-1348
Omapatrilat, a vasopeptidase inhibitor, simultaneously inhibits neutral endopeptidase and ACE. The efficacy and hormonal profile of omapatrilat and lisinopril were compared in salt-sensitive hypertensive patients. On enrollment, antihypertensive medi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d756e523f19e2d3aa4da0abbd490dd4
https://doi.org/10.1161/hy1201.096569
https://doi.org/10.1161/hy1201.096569
Autor:
Wei‐chi Liao, Ole Vesterqvist, Irene Ferreira, James Manning, Howard Uderman, Carol L. Delaney
Publikováno v:
The Journal of Clinical Pharmacology. 41:1291-1300
Pharmacodynamic effects of combination therapy with omapatrilat and furosemide were evaluated. Two groups of 13 healthy subjects each received furosemide 20 mg daily for 15 days coadministered with either placebo on days 6 to 15 or omapatrilat 10 mg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b38810f879b90c311c968e42566272a
https://doi.org/10.1177/00912700122012878
https://doi.org/10.1177/00912700122012878
Autor:
G. Ge, Ole Vesterqvist, J. Manning, B. Malhotra, Bernhard Mangold, Mohammed Jemal, P. O'Grady
Publikováno v:
European Journal of Clinical Pharmacology. 57:249-257
Objective: The pharmacodynamics and pharmacokinetics of omapatrilat, a member of a new class of cardiovascular compounds, the vasopeptidase inhibitors, were evaluated in subjects with hepatic cirrhosis (n=10) and in healthy subjects (n=10) matched fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71863b5c00e7edb93713fa10c3e0de71
https://doi.org/10.1007/s002280100291
https://doi.org/10.1007/s002280100291
Publikováno v:
Cardiovascular Research. 31:932-940
Objectives: To study calcium-independent phospholipase A2 activity during global ischemia in isolated rabbit hearts by measuring the hydrolysis of the endogenous choline phospholipids. Methods: Langendorff perfused rabbit hearts were exposed to globa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0fb7c0bb7555f25d18b00ff249f5e7b
https://doi.org/10.1016/s0008-6363(96)00060-0
https://doi.org/10.1016/s0008-6363(96)00060-0
Autor:
B.M. Warrack, Ole Vesterqvist, Gerald C. DiDonato, Gary J. Grover, Martin L. Ogletree, Carol A. Sargent
Publikováno v:
Analytical Biochemistry. 217:210-219
We have developed an assay for studying myocardial phospholipase A2 activity by measuring accumulation of lysophospholipids resulting from hydrolysis of the endogenous choline glycerophospholipid pool. This assay was used to characterize phospholipas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb1f05731f2d3f28f98d1d86544fb63a
https://doi.org/10.1006/abio.1994.1111
https://doi.org/10.1006/abio.1994.1111