Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Ole Tietz"'
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals.
The intracellular environment hosts a large number of cancer- and other disease-relevant human proteins. Targeting these with internalized antibodies would allow therapeutic modulation of hitherto undruggable pathways, such as those mediated by prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3da600cf5aa319159e0ef01eb08b7e66
https://ora.ox.ac.uk/objects/uuid:f3c9a70f-2fd9-4b50-bd9f-c7b84afefd81
https://ora.ox.ac.uk/objects/uuid:f3c9a70f-2fd9-4b50-bd9f-c7b84afefd81
Autor:
David Klenerman, Stephen Thompson, Yanyan Zhao, Elisabetta Ronchi, Benjamin Vallin, Wei-Li Kuan, Franklin I. Aigbirhio, Abdul Karim Haji-Dheere, Ole Tietz, Gergely Toth
Publikováno v:
Chemical Science
Soluble forms of aggregated tau misfolded protein, generally termed oligomers, are considered to be the most toxic species of the different assembly states that are the pathological components of neurodegenerative disorders. Therefore, a critical bio
Autor:
Yanyan Zhao, Roger A. Barker, Xiaoling He, Franklin I. Aigbirhio, Katherine Stott, Jessica C. F. Kwok, Wei-Li Kuan, Sujeong Yang, Tobias C. Wood, Katie Hall, Anthony C. Vernon, Ole Tietz
Publikováno v:
Molecular Psychiatry
Kuan, W-L, Stott, K, He, X, Wood, T, Yang, S, Kwok, J, Hall, K, Zhao, Y, Tietz, O, Aigbirhio, F, Vernon, A & Barker, R 2021, ' Systemic α-synuclein injection triggers selective neuronal pathology as seen in patients with Parkinson’s disease ', Molecular Psychiatry, vol. 26, no. 2, pp. 556–567 . https://doi.org/10.1038/s41380-019-0608-9
Kuan, W-L, Stott, K, He, X, Wood, T, Yang, S, Kwok, J, Hall, K, Zhao, Y, Tietz, O, Aigbirhio, F, Vernon, A & Barker, R 2021, ' Systemic α-synuclein injection triggers selective neuronal pathology as seen in patients with Parkinson’s disease ', Molecular Psychiatry, vol. 26, no. 2, pp. 556–567 . https://doi.org/10.1038/s41380-019-0608-9
Parkinson’s disease (PD) is an α-synucleinopathy characterized by the progressive loss of specific neuronal populations. Here, we develop a novel approach to transvascularly deliver proteins of complex quaternary structures, including α-synuclein
Autor:
Ole Tietz, Philip A. Waghorn, Robert Carlisle, Mark R. Jackson, Lei Song, Martin R. Gill, Irini Skaripa-Koukelli, Madalena Tarsounas, Bas M. Bavelaar, Sarah Able, Katherine A. Vallis
Publikováno v:
Molecular Pharmaceutics
Telomerase represents an attractive target in oncology as it is expressed in cancer but not in normal tissues. The oligonucleotide inhibitors of telomerase represent a promising anticancer strategy, although poor cellular uptake can restrict their ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddc6ba5b5cd67a99da8a217626dd2550
https://ora.ox.ac.uk/objects/uuid:ef1fdf06-d47c-4d62-b7f0-c056d58b0ace
https://ora.ox.ac.uk/objects/uuid:ef1fdf06-d47c-4d62-b7f0-c056d58b0ace
Autor:
Yanyan Zhao, Ole Tietz, Veronika Cubinkova, Norbert Žilka, Lindsay McMurray, Aviva M. Tolkovsky, Tomas Smolek, David W. Williamson, Jennifer A. Macdonald, Nisha K. Ramakrishnan, Michel Goedert, Xiaoyun Zhou, Steven G. Fagan, Franklin I. Aigbirhio, Steven Kealey, Maria Grazia Spillantini
Publikováno v:
ACS Chem. Neurosci.
ACS Chemical Neuroscience
ACS Chemical Neuroscience
Aggregated tau protein is a core pathology present in several neurodegenerative diseases. Therefore, the development and application of positron emission tomography (PET) imaging radiotracers that selectively bind to aggregated tau in fibril form is
Autor:
Sarah Able, Martin R. Gill, Ole Tietz, Abirami Lakshminarayanan, Afaf H. El-Sagheer, Rachel Anderson, Tom Brown, Katherine A. Vallis, Michael G. Walker, Rod Chalk, Jim A. Thomas
Theranostic radionuclides that emit Auger electrons (AE) can generate highly localised DNA damage and the accompanying gamma ray emission can be used for single-photon emission computed tomography (SPECT) imaging. Mismatched DNA base pairs (mismatche
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::908a328f8e177ad675faf6c7ce6943a6
https://ora.ox.ac.uk/objects/uuid:d6feda20-7ffe-42bc-b3bf-4587ff07cdb0
https://ora.ox.ac.uk/objects/uuid:d6feda20-7ffe-42bc-b3bf-4587ff07cdb0
Autor:
Martin R, Gill, Michael G, Walker, Sarah, Able, Ole, Tietz, Abirami, Lakshminarayanan, Rachel, Anderson, Rod, Chalk, Afaf H, El-Sagheer, Tom, Brown, Jim A, Thomas, Katherine A, Vallis
Publikováno v:
Chemical Science
Auger electron emitter indium-111 demonstrates cancer-selective radiotoxicity and SPECT imaging compatibility when conjugated to a ruthenium(ii) polypyridyl complex.
Theranostic radionuclides that emit Auger electrons (AE) can generate highly lo
Theranostic radionuclides that emit Auger electrons (AE) can generate highly lo
Publikováno v:
Nuclear Medicine and Biology. :9-17
Introduction Non-invasive imaging of COX-2 in cancer represents a powerful tool for assessing COX-2-mediated effects on chemoprevention and radiosensitization using potent and selective COX-2 inhibitors as an emerging class of anticancer drugs. Caref
Autor:
Ole Tietz, Laurent Chazalviel, Anne Marie Frelin-Labalme, Samuel Valable, Manuel Sarmiento Soto, Jérôme Toutain, Myriam Bernaudin, Elodie A. Pérès, Katherine A. Vallis, Didier Divoux, Aurélien Corroyer-Dulmont, Nicola R. Sibson, Nadia Falzone
Publikováno v:
ICRR 2019
ICRR 2019, Aug 2019, Manchester, United Kingdom
12èmes journées scientifiques du Cancéropôle Nord-Ouest
12èmes journées scientifiques du Cancéropôle Nord-Ouest, May 2019, Deauville, France
Neuro-Oncology
Neuro-Oncology, Oxford University Press (OUP), 2019, 22 (3), pp.357-368. ⟨10.1093/neuonc/noz169⟩
Brain & Brain Pet 2019
Brain & Brain Pet 2019, Jul 2019, Yokohama, Japan. Journal of cerebral blood flow and metabolism, 39 (PB03-G06), pp.409-409
Neuro-Oncology, 2019, 22 (3), pp.357-368. ⟨10.1093/neuonc/noz169⟩
4ème Journée Normande de Recherche Biomédicale, JNRB 2019
4ème Journée Normande de Recherche Biomédicale, JNRB 2019, Nov 2019, Caen, France
ICRR 2019, Aug 2019, Manchester, United Kingdom
12èmes journées scientifiques du Cancéropôle Nord-Ouest
12èmes journées scientifiques du Cancéropôle Nord-Ouest, May 2019, Deauville, France
Neuro-Oncology
Neuro-Oncology, Oxford University Press (OUP), 2019, 22 (3), pp.357-368. ⟨10.1093/neuonc/noz169⟩
Brain & Brain Pet 2019
Brain & Brain Pet 2019, Jul 2019, Yokohama, Japan. Journal of cerebral blood flow and metabolism, 39 (PB03-G06), pp.409-409
Neuro-Oncology, 2019, 22 (3), pp.357-368. ⟨10.1093/neuonc/noz169⟩
4ème Journée Normande de Recherche Biomédicale, JNRB 2019
4ème Journée Normande de Recherche Biomédicale, JNRB 2019, Nov 2019, Caen, France
Background Brain metastases (BM) develop frequently in patients with breast cancer. Despite the use of external beam radiotherapy (EBRT), the average overall survival is short (6 months from diagnosis). The therapeutic challenge is to deliver molecul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3131861cde96343ba2769b3d1e691987
https://hal-normandie-univ.archives-ouvertes.fr/hal-02266822
https://hal-normandie-univ.archives-ouvertes.fr/hal-02266822