Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Ole Thastrup"'
Autor:
Sarah Line Bring Truelsen, Nabi Mousavi, Haoche Wei, Lucy Harvey, Rikke Stausholm, Erik Spillum, Grith Hagel, Klaus Qvortrup, Ole Thastrup, Henrik Harling, Harry Mellor, Jacob Thastrup
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0253258 (2021)
The treatment response to anti-angiogenic agents varies among cancer patients and predictive biomarkers are needed to identify patients with resistant cancer or guide the choice of anti-angiogenic treatment. We present "the Cancer Angiogenesis Co-Cul
Externí odkaz:
https://doaj.org/article/5310916ac9324f84825d18d85b90f7db
Autor:
Sigrid S. Árnadóttir, Maria Jeppesen, Philippe Lamy, Jesper B. Bramsen, Iver Nordentoft, Michael Knudsen, Søren Vang, Mogens R. Madsen, Ole Thastrup, Jacob Thastrup, Claus L. Andersen
Publikováno v:
Molecular Oncology, Vol 12, Iss 1, Pp 132-147 (2018)
Patient‐derived in vitro cultures of colorectal cancer (CRC) may help guide treatment strategies prior to patient treatment. However, most previous studies have been performed on a single biopsy per tumor. The purpose of this study was to analyze m
Externí odkaz:
https://doaj.org/article/d25f2bdbf3e844efbdfafe4d3439846a
Autor:
Maria Jeppesen, Grith Hagel, Anders Glenthoj, Ben Vainer, Per Ibsen, Henrik Harling, Ole Thastrup, Lars N Jørgensen, Jacob Thastrup
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0183074 (2017)
Chemotherapy treatment of cancer remains a challenge due to the molecular and functional heterogeneity displayed by tumours originating from the same cell type. The pronounced heterogeneity makes it difficult for oncologists to devise an effective th
Externí odkaz:
https://doaj.org/article/9df1d329274e465686b17eb5dcc4db76
Autor:
Michael Linnebacher, Dominik Nörz, Daniel J Smit, Ole Thastrup, Manfred Jücker, Alp Mirdogan, Patrick Ehm, Andreas Block, Jakob R. Izbicki, Jacqueline Siekiera, Christina S Mullins, Grith Hagel
Publikováno v:
Anticancer Research. 41:2257-2275
Background Pre-therapeutic analysis of three-dimensional spheroid cultures of primary tumour samples is a promising approach of assessing susceptibility to potential treatment. The phosphatidylinositol-3-kinase/AKT serine/threonine kinase/mammalian t
Autor:
Henrik Harling, Ole Thastrup, Erik Spillum, Sarah Line Bring Truelsen, Grith Hagel, Jacob Thastrup, Klaus Qvortrup, Nabi Mousavi, Harry Mellor, Rikke Stausholm, Haoche Wei, Lucy Harvey
Publikováno v:
Truelsen, S L B, Mousavi, N, Wei, H, Harvey, L, Stausholm, R, Spillum, E, Hagel, G, Qvortrup, K, Thastrup, O, Harling, H, Mellor, H & Thastrup, J 2021, ' The cancer angiogenesis co-culture assay : In vitro quantification of the angiogenic potential of tumoroids ', PLoS ONE, vol. 16, no. 7, e0253258, pp. e0253258 . https://doi.org/10.1371/journal.pone.0253258
Truelsen, S L B, Mousavi, N, Wei, H, Harvey, L, Stausholm, R, Spillum, E, Hagel, G, Qvortrup, K, Thastrup, O, Harling, H, Mellor, H & Thastrup, J 2021, ' The cancer angiogenesis co-culture assay : In vitro quantification of the angiogenic potential of tumoroids ', PLoS ONE, vol. 16, no. 7 July, e0253258 . https://doi.org/10.1371/journal.pone.0253258
PLoS ONE, Vol 16, Iss 7, p e0253258 (2021)
PLoS ONE
Truelsen, S L B, Mousavi, N, Wei, H, Harvey, L, Stausholm, R, Spillum, E, Hagel, G, Qvortrup, K, Thastrup, O, Harling, H, Mellor, H & Thastrup, J 2021, ' The cancer angiogenesis co-culture assay : In vitro quantification of the angiogenic potential of tumoroids ', PLoS ONE, vol. 16, no. 7 July, e0253258 . https://doi.org/10.1371/journal.pone.0253258
PLoS ONE, Vol 16, Iss 7, p e0253258 (2021)
PLoS ONE
The treatment response to anti-angiogenic agents varies among cancer patients and predictive biomarkers are needed to identify patients with resistant cancer or guide the choice of anti-angiogenic treatment. We present “the Cancer Angiogenesis Co-C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3631e4d8e62bc2a94ccfe60a5af2b96d
https://hdl.handle.net/1983/86fb7c9a-facd-4b9e-b933-19dfe42ac799
https://hdl.handle.net/1983/86fb7c9a-facd-4b9e-b933-19dfe42ac799
Autor:
Dominik, Nörz, Christina S, Mullins, Daniel J, Smit, Michael, Linnebacher, Grith, Hagel, Alp, Mirdogan, Jacqueline, Siekiera, Patrick, Ehm, Jakob R, Izbicki, Andreas, Block, Ole, Thastrup, Manfred, Jücker
Publikováno v:
Anticancer research. 41(5)
Pre-therapeutic analysis of three-dimensional spheroid cultures of primary tumour samples is a promising approach of assessing susceptibility to potential treatment. The phosphatidylinositol-3-kinase/AKT serine/threonine kinase/mammalian target of ra
Autor:
Ole Thastrup, Torben Hansen, Birgitte Mayland Havelund, Chris Aksel Vagn-Hansen, G. Hagel, Henrik Harling, Claus Dam, Anders Jakobsen, Lars Henrik Jensen, Søren Rafael Rafaelsen, Jan Lindebjerg
Publikováno v:
Jensen, L H, Dam, C, Hagel, G, Vagn-Hansen, C, Harling, H, Havelund, B M, Jakobsen, A, Lindebjerg, J, Rafaelsen, S R, Thastrup, O & Hansen, T F 2019, ' Factors of importance in procuring tumoroids from colorectal liver metastasis biopsies for precision medicine ', Annals of Oncology, vol. 30, no. Suppl. 5, 568P, pp. 214 . https://doi.org/10.1093/annonc/mdz246.045
Background Tumour tissue from individual patients with colorectal cancer may be cultured in vitro as three-dimensional tumoroids that resembles the biological features in vivo including chemotherapy sensitivity and resistance. Tumoroid formation is w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ec38cd1513963502d745238a365b301
https://portal.findresearcher.sdu.dk/da/publications/f7e096e9-5b18-405a-a8be-e9e24558804b
https://portal.findresearcher.sdu.dk/da/publications/f7e096e9-5b18-405a-a8be-e9e24558804b
Autor:
Torben Hansen, C. Hansen, G. Hagel, Lars Henrik Jensen, Ole Thastrup, Anders Jakobsen, Henrik Harling, Claus Dam, Birgitte Mayland Havelund, Jan Lindebjerg, Søren Rafael Rafaelsen
Publikováno v:
Jensen, L H, Dam, C, Hagel, G, Hansen, C, Harling, H, Havelund, B M, Jakobsen, A, Lindebjerg, J, Rafaelsen, S, Thastrup, O & Hansen, T F 2018, ' Predictive value of in-vitro testing anti-cancer therapy sensitivity on 3D micro-tumors (tumoroids) from patients with metastatic colorectal cancer: A feasibility study ', Annals of Oncology, vol. 29, no. Suppl. 8, pp. viii198 . https://doi.org/10.1093/annonc/mdy281.142
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8adffa0a03421816eb043fd25b6a9b80
https://portal.findresearcher.sdu.dk/da/publications/f4d9314e-9bb8-464d-8211-d246fc9a6810
https://portal.findresearcher.sdu.dk/da/publications/f4d9314e-9bb8-464d-8211-d246fc9a6810
Autor:
Michael Knudsen, Jacob Thastrup, Mogens Madsen, Philippe Lamy, Sigrid S. Árnadóttir, Maria Jeppesen, Iver Nordentoft, Søren Vang, Ole Thastrup, Claus L. Andersen, Jesper B. Bramsen
Publikováno v:
Molecular Oncology
Árnadóttir, S S, Jeppesen, M, Lamy, P, Bramsen, J B, Nordentoft, I, Knudsen, M, Vang, S, Madsen, M R, Thastrup, O, Thastrup, J & L Andersen, C 2018, ' Characterization of genetic intratumor heterogeneity in colorectal cancer and matching patient-derived spheroid cultures ', Molecular Oncology, vol. 12, pp. 132-147 . https://doi.org/10.1002/1878-0261.12156
Molecular Oncology, Vol 12, Iss 1, Pp 132-147 (2018)
Árnadóttir, S S, Jeppesen, M, Lamy, P, Bramsen, J B, Nordentoft, I, Knudsen, M, Vang, S, Madsen, M R, Thastrup, O, Thastrup, J & L Andersen, C 2018, ' Characterization of genetic intratumor heterogeneity in colorectal cancer and matching patient-derived spheroid cultures ', Molecular Oncology, vol. 12, no. 1, pp. 132–147 . https://doi.org/10.1002/1878-0261.12156
Árnadóttir, S S, Jeppesen, M, Lamy, P, Bramsen, J B, Nordentoft, I, Knudsen, M, Vang, S, Madsen, M R, Thastrup, O, Thastrup, J & L Andersen, C 2018, ' Characterization of genetic intratumor heterogeneity in colorectal cancer and matching patient-derived spheroid cultures ', Molecular Oncology, vol. 12, pp. 132-147 . https://doi.org/10.1002/1878-0261.12156
Molecular Oncology, Vol 12, Iss 1, Pp 132-147 (2018)
Árnadóttir, S S, Jeppesen, M, Lamy, P, Bramsen, J B, Nordentoft, I, Knudsen, M, Vang, S, Madsen, M R, Thastrup, O, Thastrup, J & L Andersen, C 2018, ' Characterization of genetic intratumor heterogeneity in colorectal cancer and matching patient-derived spheroid cultures ', Molecular Oncology, vol. 12, no. 1, pp. 132–147 . https://doi.org/10.1002/1878-0261.12156
Patient-derived in vitro cultures of colorectal cancer (CRC) may help guide treatment strategies prior to patient treatment. However, most previous studies have been performed on a single biopsy per tumor. The purpose of this study was to analyze mul
Autor:
Per Ibsen, Ben Vainer, Maria Jeppesen, Jacob Thastrup, Ole Thastrup, Anders Glenthøj, Lars N. Jorgensen, Grith Hagel, Henrik Harling
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0183074 (2017)
Jeppesen, M, Hagel, G, Glenthoj, A, Vainer, B, Ibsen, P, Harling, H, Thastrup, O, Jørgensen, L N & Thastrup, J 2017, ' Short-term spheroid culture of primary colorectal cancer cells as an in vitro model for personalizing cancer medicine ', PLOS ONE, vol. 12, no. 9, e0183074 . https://doi.org/10.1371/journal.pone.0183074
PLoS ONE
Jeppesen, M, Hagel, G, Glenthoj, A, Vainer, B, Ibsen, P, Harling, H, Thastrup, O, Jørgensen, L N & Thastrup, J 2017, ' Short-term spheroid culture of primary colorectal cancer cells as an in vitro model for personalizing cancer medicine ', PLOS ONE, vol. 12, no. 9, e0183074 . https://doi.org/10.1371/journal.pone.0183074
PLoS ONE
Chemotherapy treatment of cancer remains a challenge due to the molecular and functional heterogeneity displayed by tumours originating from the same cell type. The pronounced heterogeneity makes it difficult for oncologists to devise an effective th