Zobrazeno 1 - 10
of 503
pro vyhledávání: '"Ole Haagen, Nielsen"'
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110118- (2024)
Summary: Inflammatory bowel disease (IBD) is a chronic disorder with an increasing global prevalence. Managing disease activity relies on various pharmacological options. However, the effectiveness of current therapeutics is limited and not universal
Externí odkaz:
https://doaj.org/article/4557e5fca03e40ca901e681a67dd9748
Publikováno v:
Microorganisms, Vol 12, Iss 3, p 576 (2024)
The protective intestinal epithelial barrier is constantly exposed to more than 100 trillion commensal microorganisms (bacteria, archaea, viruses, and fungi), i [...]
Externí odkaz:
https://doaj.org/article/3d4f9089ccae47f6827ea93e23b8a6f1
Autor:
Mohamed Attauabi, Emilie Kristine Dahl, Johan Burisch, John Gubatan, Ole Haagen Nielsen, Jakob Benedict Seidelin
Publikováno v:
EClinicalMedicine, Vol 57, Iss , Pp 101866- (2023)
Summary: Background: Onset of effect of advanced therapies is an important parameter due to symptom load and risk of disease complications in moderate-to-severe ulcerative colitis (UC), but comparative data are lacking. Therefore, we aimed to assess
Externí odkaz:
https://doaj.org/article/64b4b3b8696343659d15f9246748f9b0
Autor:
Ole Haagen Nielsen, Søren Jacobsen, Inge Marie Svane, Julia Sidenius Johansen, Dorte Lisbet Nielsen, Peter Vilmann, Lene Buhl Riis, Rikke Boedker Holmstroem, Susann Theile, Jacob Tveiten Bjerrum, Mogens Karsbøl Boisen, Rikke Helene Løvendahl Eefsen, Inna Markovna Chen
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 9 (2022)
Background Immune-related adverse events due to immune checkpoint inhibitors (ICIs) are not always effectively treated using glucocorticoids and it may negatively affect the antitumor efficacy of ICIs. Interventional studies of alternatives to glucoc
Externí odkaz:
https://doaj.org/article/da6a783c8a484ee48ff0fad18bb11269
Publikováno v:
eLife, Vol 11 (2022)
Microscopic colitis is an inflammatory bowel disease divided into two subtypes: collagenous colitis and lymphocytic colitis. With an increasing incidence of microscopic colitis exceeding those of ulcerative and Crohn’s disease among elderly people
Externí odkaz:
https://doaj.org/article/81d5cbcd9c404def85a2ee22ab121dfa
Autor:
Deepavali Chakravarti, Baoli Hu, Xizeng Mao, Asif Rashid, Jiexi Li, Jun Li, Wen-ting Liao, Elizabeth M. Whitley, Prasenjit Dey, Pingping Hou, Kyle A. LaBella, Andrew Chang, Guocan Wang, Denise J. Spring, Pingna Deng, Di Zhao, Xin Liang, Zhengdao Lan, Yiyun Lin, Sharmistha Sarkar, Christopher Terranova, Yonathan Lissanu Deribe, Sarah E. Blutt, Pablo Okhuysen, Jianhua Zhang, Eduardo Vilar, Ole Haagen Nielsen, Andrew Dupont, Mamoun Younes, Kalyani R. Patel, Noah F. Shroyer, Kunal Rai, Mary K. Estes, Y. Alan Wang, Alison A. Bertuch, Ronald A. DePinho
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
How telomere dysfunction is directly linked to inflammation in humans is currently unclear. Here the authors reveal that telomere dysfunction drives activation of the YAP1 transcription factor, up-regulating the pro inflammatory factor, pro-IL-18 thu
Externí odkaz:
https://doaj.org/article/b5a35bee98a746039f8bae5793248657
Autor:
Sebastian Kjærgaard Hendel, Lauge Kellermann, Annika Hausmann, Niels Bindslev, Kim Bak Jensen, Ole Haagen Nielsen
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The interests in intestinal epithelial tuft cells, their basic physiology, involvement in immune responses and relevance for gut diseases, have increased dramatically over the last fifteen years. A key discovery in 2016 of their close connection to h
Externí odkaz:
https://doaj.org/article/5c3219b04c494a48b1ada5d231af0cd9
Autor:
Fredrik Bergenheim, Jakob B. Seidelin, Marianne Terndrup Pedersen, Benjamin E. Mead, Kim B. Jensen, Jeffrey M. Karp, Ole Haagen Nielsen
Publikováno v:
Stem Cell Research & Therapy, Vol 10, Iss 1, Pp 1-12 (2019)
Abstract Background Intestinal stem cell transplantation has been shown to promote mucosal healing and to engender fully functional epithelium in experimental colitis. Hence, stem cell therapies may provide an innovative approach to accomplish mucosa
Externí odkaz:
https://doaj.org/article/9de7ea84ddd94ae6bdcac4f7ba09c93f
Autor:
John Gubatan, Theresa Louise Boye, Michelle Temby, Raoul S. Sojwal, Derek R. Holman, Sidhartha R. Sinha, Stephan R. Rogalla, Ole Haagen Nielsen
Publikováno v:
Microorganisms, Vol 10, Iss 7, p 1371 (2022)
The gut microbiome has increasingly been recognized as a critical and central factor in inflammatory bowel disease (IBD). Here, we review specific microorganisms that have been suggested to play a role in the pathogenesis of IBD and the current state
Externí odkaz:
https://doaj.org/article/76bf4c6a9f714a46adc7b40019cc28e5
Publikováno v:
EClinicalMedicine, Vol 20, Iss , Pp - (2020)
Background: The therapeutic role of methotrexate (MTX) for management of inflammatory bowel disease (IBD) remains unclear. Methods: We systematically reviewed randomized, controlled trials (RCTs) of MTX for induction and maintenance of remission in I
Externí odkaz:
https://doaj.org/article/c32eba252a0342459eab7324b91976b4