Zobrazeno 1 - 10
of 330
pro vyhledávání: '"Ole Buchardt"'
Publikováno v:
International Journal of Peptide and Protein Research. 41:169-180
A series of model peptides with a C-terminal protected amide group were prepared by enzymatic transacylation. The protection groups were removed by photolysis to give the warranted peptide amides in high yields. Furthermore, fragments of human calcit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::997618d09def0386f23dc673977d5cf8
https://doi.org/10.1111/j.1399-3011.1993.tb00128.x
https://doi.org/10.1111/j.1399-3011.1993.tb00128.x
Autor:
Peter E. Nielsen, Ole Buchardt
Publikováno v:
Photochemistry and Photobiology. 35:317-323
— The photochemistry of a series of aryl azides used in, or closely related to some of those used in photoaffinity labeling studies, has been investigated by flash photolysis, continuous irradiation and low-temperature irradiation with IR and UV sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef42b6b9e561bb74f1ddc6f52f90c1b8
https://doi.org/10.1111/j.1751-1097.1982.tb02568.x
https://doi.org/10.1111/j.1751-1097.1982.tb02568.x
Publikováno v:
Protein & Peptide Letters. 5:141-146
Abstract: Various protected aspartic acid ex-amide and glutamic acid ex-amide derivatives were synthesized and applied as nucleophiles in transacylation reactions using carboxypeptidase Y. The benzyl, tert-butyl, cyclohexyl and cyclopentyl ester-type
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96bd29f005751a18904e5efb48ab781f
https://doi.org/10.2174/092986650503221107160723
https://doi.org/10.2174/092986650503221107160723
Publikováno v:
Angewandte Chemie International Edition in English. 35:1939-1942
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff4ce954e87785b861c36c62e20faf18
https://doi.org/10.1002/anie.199619391
https://doi.org/10.1002/anie.199619391
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:1083-1088
The positively charged and relatively flexible PNA unit ethT (Fig. 1) has an ethylene linker between backbone and nucleobase rather than the methylene carbonyl linker normally present in PNA. The synthesis of the corresponding modified monomer, its i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4024afd52fc913dfd979e2c3027d3386
https://doi.org/10.1016/0960-894x(96)00176-x
https://doi.org/10.1016/0960-894x(96)00176-x
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:793-796
The synthesis of a new DNA analogue based on ornithine is described. Only the thymine analogue was synthesised. A 10 mer entirely made up of the thymine monomer forms a triple helix with poly RNA A. The Tm of the triplex was 21°C.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ed1777330c868c0ee74b7e24bf9f8f4
https://doi.org/10.1016/0960-894x(96)00121-7
https://doi.org/10.1016/0960-894x(96)00121-7
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:1119-1124
N -(2-benzyloxyethyl)- N -(thymin-1-ylacetyl)glycine was synthesised and used as a linker for coupling DNA and PNA together. Three different 10-mers composed of 6 DNA units and 4 PNA thymine units were made. The PNA-DNA chimera hybridise to complemen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb8506fa7565cdec5081ecf667522f92
https://doi.org/10.1016/0960-894x(95)00177-u
https://doi.org/10.1016/0960-894x(95)00177-u
Autor:
Kenneth H. Petersen, Leif Christensen, Troels Koch, Henrik Hansen, Brian D. Gildea, Ole Buchardt, Michael Egholm, Peter E. Nielsen, Rolf H. Berg, James M. Coull, Richard Fitzpatrick
Publikováno v:
Journal of Peptide Science. 1:175-183
Peptide nucleic acids (PNA) were synthesized by a modified Merrifield method using several improvements. Activation by O-[benzotriazol-1-yl]-1,1,3,3-tetramethyluronium hexafluorophosphate in combination with in situ neutralization of the resin allowe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07d6e7205cf3f305d49cafd33bf76dd8
https://doi.org/10.1002/psc.310010304
https://doi.org/10.1002/psc.310010304
Publikováno v:
Gene. 149:139-145
The effects of PNA (peptide nucleic acid) bound to double-stranded (ds) DNA targets positioned downstream from phage T3 or T7 promoters in pBluescriptKS+ derived plasmids on transcription by RNA polymerases T3 or T7 have been studied. The dsDNA targe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff9835e0dd0201549201cae6b22e25c4
https://doi.org/10.1016/0378-1119(94)90422-7
https://doi.org/10.1016/0378-1119(94)90422-7
Autor:
Leif Christensen, Kim L. Dueholm, Ole Buchardt, Michael Egholm, Carsten Behrens, Henrik Hansen, Kenneth H. Petersen, Peter E. Nielsen, Tore Vulpius, Rolf H. Berg
Publikováno v:
The Journal of Organic Chemistry. 59:5767-5773
The preparation of mixed-sequence PNAs (PNAs containing the four natural nucleobases; thymine, cytosine, adenine, and guanine) is described. The PNA monomers containing thymine, Cbz-protected cytosine, or adenine or benzyl-protected guanine were prep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93e4aa37354e115a43dfb4f327d18a79
https://doi.org/10.1021/jo00098a042
https://doi.org/10.1021/jo00098a042