Zobrazeno 1 - 10
of 235
pro vyhledávání: '"Ole‐Bjørn Tysnes"'
Autor:
Camilla Christina Pedersen, Anastasia Ushakova, Guido Alves, Ole-Bjørn Tysnes, Kaj Blennow, Henrik Zetterberg, Jodi Maple-Grødem, Johannes Lange
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-6 (2024)
Abstract Neurofilament light chain (NFL) is elevated in neurodegenerative diseases, including Parkinson’s disease (PD). This study aimed to investigate serum NFL in newly diagnosed PD and its association with cognitive and motor decline over 10 yea
Externí odkaz:
https://doaj.org/article/87330a2ead404de697c1a54b4b1471e8
Autor:
Irene H. Flønes, Lilah Toker, Dagny Ann Sandnes, Martina Castelli, Sepideh Mostafavi, Njål Lura, Omnia Shadad, Erika Fernandez-Vizarra, Cèlia Painous, Alexandra Pérez-Soriano, Yaroslau Compta, Laura Molina-Porcel, Guido Alves, Ole-Bjørn Tysnes, Christian Dölle, Gonzalo S. Nido, Charalampos Tzoulis
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Idiopathic Parkinson’s disease (iPD) is believed to have a heterogeneous pathophysiology, but molecular disease subtypes have not been identified. Here, we show that iPD can be stratified according to the severity of neuronal respiratory c
Externí odkaz:
https://doaj.org/article/ca1314f7e4514676b9bb0eefc96db530
Autor:
Zeynep Tufekcioglu, Johannes Lange, Kenn Freddy Pedersen, Ole-Bjørn Tysnes, Guido Alves, Murat Emre
Publikováno v:
Dementia and Geriatric Cognitive Disorders Extra, Vol 13, Iss 1, Pp 39-47 (2023)
Introduction: In patients with Parkinson’s disease (PD), low cerebrospinal fluid (CSF) amyloid beta 1-42 (Ab42) at baseline is the most consistent CSF biomarker as a risk factor for developing dementia. Low CSF Ab42 is, however, a typical hallmark
Externí odkaz:
https://doaj.org/article/8b06be49469348fc9882a199b4a7d9fb
Autor:
Linn Oftedal, Johannes Lange, Kenn Freddy Pedersen, Aleksander Hagen Erga, Ingvild Dalen, Ole-Bjørn Tysnes, Guido Alves, Jodi Maple-Grødem
Publikováno v:
Translational Neurodegeneration, Vol 12, Iss 1, Pp 1-4 (2023)
Externí odkaz:
https://doaj.org/article/23944c369f344b33868e97061155475a
Autor:
Jodi Maple-Grødem, Anastasia Ushakova, Kenn Freddy Pedersen, Ole-Bjørn Tysnes, Guido Alves, Johannes Lange
Publikováno v:
Neurobiology of Disease, Vol 186, Iss , Pp 106281- (2023)
Given the complexity of Parkinson's disease (PD), achieving acceptable diagnostic and prognostic accuracy will require the support of a panel of diverse biomarkers. We used Proximity extension assays to measure a panel of 92 proteins in CSF of 120 ne
Externí odkaz:
https://doaj.org/article/27747f555589467c876ebc76c0db8051
Publikováno v:
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-5 (2022)
Abstract Identification of factors predicting and driving mortality in PD is important for patient information, disease management, and design of future clinical trials. This study included newly diagnosed PD patients and normal controls (NC) from a
Externí odkaz:
https://doaj.org/article/95762fb0997f41cf8ef18aff406207ee
Publikováno v:
iScience, Vol 26, Iss 2, Pp 105925- (2023)
Summary: Aberrant proteostasis is thought to be implicated in Parkinson’s disease (PD), but patient-derived evidence is scant. We hypothesized that impaired proteostasis is reflected as altered transcriptome-proteome correlation in the PD brain. We
Externí odkaz:
https://doaj.org/article/48dcb96d44704c7ebb988cb45c08b922
Autor:
Tina Taule, Irmelin Smith Eide, Line Fjær, Mari-Anne Myrberget, Marit Sofie Oseland, Marit Arnevik Renså, Tone Revheim, Ole-Bjørn Tysnes, Jörg Aßmus, Tiina Rekand
Publikováno v:
PLoS ONE, Vol 18, Iss 5, p e0285307 (2023)
BackgroundResearch collaboration highlight a need for validated tests in other languages than English. Translation and culture adjustments may threaten essential features of the original instrument.ObjectiveTo assess the internal consistency, inter-r
Externí odkaz:
https://doaj.org/article/3a775cf9a1174145a61e214f4565b497
Autor:
Lilah Toker, Gia T. Tran, Janani Sundaresan, Ole-Bjørn Tysnes, Guido Alves, Kristoffer Haugarvoll, Gonzalo S. Nido, Christian Dölle, Charalampos Tzoulis
Publikováno v:
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-20 (2021)
Abstract Background Parkinson’s disease (PD) is a complex, age-related neurodegenerative disorder of largely unknown etiology. PD is strongly associated with mitochondrial respiratory dysfunction, which can lead to epigenetic dysregulation and spec
Externí odkaz:
https://doaj.org/article/9fc79b5444a44fc3bd31f3e48ea449ed
Autor:
Gonzalo S. Nido, Fiona Dick, Lilah Toker, Kjell Petersen, Guido Alves, Ole-Bjørn Tysnes, Inge Jonassen, Kristoffer Haugarvoll, Charalampos Tzoulis
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-14 (2020)
Abstract The etiology of Parkinson’s disease is largely unknown. Genome-wide transcriptomic studies in bulk brain tissue have identified several molecular signatures associated with the disease. While these studies have the potential to shed light
Externí odkaz:
https://doaj.org/article/8f3957982f06408db16e18a6596a3592